The Effect of Coatings on the Affinity of Lanthanide Nanoparticles to MKN45 and HeLa Cancer Cells and Improvement in Photodynamic Therapy Efficiency

Sawamura, Takashi; Tanaka, T.; Ishige, Hiroyuki; Iizuka, Masayuki; Murayama, Yasutoshi; Otsuji, Eigo; Ohkubo, Akihiro; Ogura, Shun; Yuasa, Hideya

doi:10.3390/ijms160922415

Cited by 15 publications

(9 citation statements)

References 28 publications

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“…One of the most recent and significant applications of these compounds is the design of multimodal DNA photocleavage agents in photodynamic therapy (PDT). − PDT is a treatment modality for a variety of diseases, including cancer, , that has emerged as a powerful alternative due to its noninvasive and selective nature, in which a photoactivatable drug becomes toxic only for cancerous cells, leaving the unexposed normal cells intact. This procedure involves a photosensitizing agent that, in this case, is constituted by both antenna and lanthanide fragment.…”

Section: Introductionmentioning

confidence: 99%

Theoretical Method for an Accurate Elucidation of Energy Transfer Pathways in Europium(III) Complexes with Dipyridophenazine (dppz) Ligand: One More Step in the Study of the Molecular Antenna Effect

et al. 2017

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A theoretical protocol to study the sensitization and emission mechanism in lanthanide compounds on the basis of multireference CASSCF/PT2 calculations is proposed and applied to [Eu(NO)(dppz-CN)] and [Eu(NO)(dppz-NO)] compounds synthesized and characterized herein. The method consists of a fragmentation scheme where both the ligand and the lanthanide fragments were calculated separately but at the same level of theory, using ab initio wave-function-based methods which are adequate for the treatment of quasi-degenerate states. This is based on the fact that the absorption is ligand-localized and the emission is europium-centered. This characteristic allowed us to describe the most probable energy transfer pathways that take place in the complexes, which involved an ISC between the S to T ligand states, energy transfer to D in the lanthanide fragment, and further D → F emission. For both compounds, the triplet and D states were determined at the CASPT2 level to be around ∼26000 and ∼22400 cm, respectively. This difference is in the optimal range for the energy transfer process. Finally, the emissive state D was found at ∼18000 cm and the emission bands in the range 550-700 nm, in quite good agreement with the experimental results.

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Section: Introductionmentioning

confidence: 99%

Theoretical Method for an Accurate Elucidation of Energy Transfer Pathways in Europium(III) Complexes with Dipyridophenazine (dppz) Ligand: One More Step in the Study of the Molecular Antenna Effect

et al. 2017

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“…Upconversion nanoparticles provide these means. Despite a number of reports on the photoactivation of fluorophores by UCNPs 14 21 22 , the present challenge of the photoactivation of Rf in the UV-blue spectral band is unmet by the state-of-the-art UCNPs 15 , and demands a purpose-design of UCNP to kindle its UV-blue photoluminescence.…”

Section: Resultsmentioning

confidence: 99%

Riboflavin photoactivation by upconversion nanoparticles for cancer treatment

Khaydukov¹,

Миронова²,

Семчишен³

et al. 2016

Sci Rep

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Riboflavin (Rf) is a vitamin and endogenous photosensitizer capable to generate reactive oxygen species (ROS) under UV-blue irradiation and kill cancer cells, which are characterized by the enhanced uptake of Rf. We confirmed its phototoxicity on human breast adenocarcinoma cells SK-BR-3 preincubated with 30-μM Rf and irradiated with ultraviolet light, and proved that such Rf concentrations (60 μM) are attainable in vivo in tumour site by systemic intravascular injection. In order to extend the Rf photosensitization depth in cancer tissue to 6 mm in depth, we purpose-designed core/shell upconversion nanoparticles (UCNPs, NaYF4:Yb3+:Tm3+/NaYF4) capable to convert 2% of the deeply-penetrating excitation at 975 nm to ultraviolet-blue power. This power was expended to photosensitise Rf and kill SK-BR-3 cells preincubated with UCNPs and Rf, where the UCNP-Rf energy transfer was photon-mediated with ~14% Förster process contribution. SK-BR-3 xenograft regression in mice was observed for 50 days, following the Rf-UCNPs peritumoural injection and near-infrared light photodynamic treatment of the lesions.

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“…PpIX absorption spreads across the visible spectrum peaking at the Soret band of 405 nm with smaller peaks in the longer wavelength, termed the Q band ( Figure 1B). [11] Excitation of PpIX at 405 nm, the absorption maxima, generates a single emission peak at 635 nm, which is useful for fluorescencebased quantification of PpIX ( Figure S1, Supporting Information). Although the efficiency of PpIX excitation is expected to be the highest in the Soret band, this efficiency is offset by the lower tissue penetrative power of the Soret band as compared to the Q band ( Figure S2, Supporting Information).…”

Section: Doi: 101002/adma202001459mentioning

confidence: 99%

A Flexi‐PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy

et al. 2020

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Near‐infrared (NIR) activatable upconversion nanoparticles (UCNPs) enable wireless‐based phototherapies by converting deep‐tissue‐penetrating NIR to visible light. UCNPs are therefore ideal as wireless transducers for photodynamic therapy (PDT) of deep‐sited tumors. However, the retention of unsequestered UCNPs in tissue with minimal options for removal limits their clinical translation. To address this shortcoming, biocompatible UCNPs implants are developed to deliver upconversion photonic properties in a flexible, optical guide design. To enhance its translatability, the UCNPs implant is constructed with an FDA‐approved poly(ethylene glycol) diacrylate (PEGDA) core clad with fluorinated ethylene propylene (FEP). The emission spectrum of the UCNPs implant can be tuned to overlap with the absorption spectra of the clinically relevant photosensitizer, 5‐aminolevulinic acid (5‐ALA). The UCNPs implant can wirelessly transmit upconverted visible light till 8 cm in length and in a bendable manner even when implanted underneath the skin or scalp. With this system, it is demonstrated that NIR‐based chronic PDT is achievable in an untethered and noninvasive manner in a mouse xenograft glioblastoma multiforme (GBM) model. It is postulated that such encapsulated UCNPs implants represent a translational shift for wireless deep‐tissue phototherapy by enabling sequestration of UCNPs without compromising wireless deep‐tissue light delivery.

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The Effect of Coatings on the Affinity of Lanthanide Nanoparticles to MKN45 and HeLa Cancer Cells and Improvement in Photodynamic Therapy Efficiency

Cited by 15 publications

References 28 publications

Theoretical Method for an Accurate Elucidation of Energy Transfer Pathways in Europium(III) Complexes with Dipyridophenazine (dppz) Ligand: One More Step in the Study of the Molecular Antenna Effect

Theoretical Method for an Accurate Elucidation of Energy Transfer Pathways in Europium(III) Complexes with Dipyridophenazine (dppz) Ligand: One More Step in the Study of the Molecular Antenna Effect

Riboflavin photoactivation by upconversion nanoparticles for cancer treatment

A Flexi‐PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy

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