The Effect of Clostridium difficile Infection on Pregnancy and Neonatal Outcomes: An Observational Study

Saha, Srishti; Pardi, Ryan; Pardi, Darrell S.; Khanna, Sahil

doi:10.14309/00000434-201810001-00214

Cited by 2 publications

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“…A large retrospective cohort study found that deliveries complicated by CDI doubled between 1999 and 2013 and a diagnosis of CDI was associated with 57 times greater the risk of maternal death, 8 times the risk of venous thromboembolism, and 24 times the risk of prolonged hospital stay (227). An observational study of 31 pregnant patients showed that treatment change due to adverse events or nonresolution of symptoms on metronidazole was common, occurring in 50% of those so treated (228). This study also showed higher rates of preterm birth, gestational hypertension, and adverse neonatal outcomes compared with national data.…”

Section: Other Special Populationsmentioning

confidence: 99%

ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections

et al. 2021

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Clostridioides difficile infection occurs when the bacterium produces toxin that causes diarrhea and inflammation of the colon. These guidelines indicate the preferred approach to the management of adults with C. difficile infection and represent the official practice recommendations of the American College of Gastroenterology. The scientific evidence for these guidelines was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation process. In instances where the evidence was not appropriate for Grading of Recommendations Assessment, Development, and Evaluation but there was consensus of significant clinical merit, key concept statements were developed using expert consensus. These guidelines are meant to be broadly applicable and should be viewed as the preferred, but not the only, approach to clinical scenarios.

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Section: Other Special Populationsmentioning

confidence: 99%

ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections

et al. 2021

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“…studios han demostrado que la incidencia de infección por Clostridioides difficile (ICD) ha aumentado no solo en la población general sino también en mujeres embarazadas 1,2 . Un estudio retrospectivo que incluyó 31 mujeres embarazadas mostró que la ICD durante el embarazo podría estar asociada a tasas más altas de fracaso a tratamiento con antibacterianos y mayor probabilidad de resultados adversos al término de la gestación, al compararlo con mujeres embarazadas sin ICD 3 .…”

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Trasplante de microbiota fecal por colonoscopía en una mujer embarazada con infección recurrente por Clostridioides difficile

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Espinoza

et al. 2022

Rev. chil. infectol.

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El diagnóstico de la infección por Clostridioides difficile (ICD) ha aumentado en el embarazo y periparto. Cambios fisiológicos e inmunológicos normales durante el embarazo pueden incrementar el riesgo de ICD. Mujeres embarazadas con ICD tienen una mayor frecuencia de fracaso al tratamiento y una significativa morbilidad y mortalidad. El trasplante de microbiota fecal (TMF) se ha convertido en el tratamiento estándar de la ICD recurrente y refractaria. Sin embargo, existen escasos datos sobre sus resultados en mujeres embarazadas. Presentamos el caso de una mujer embarazada que se sometió con éxito a un TMF para el tratamiento de una ICD recurrente.Palabras claves: Clostridioides difficile; trasplante microbiota fecal; periparto; embarazo.

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The Effect of Clostridium difficile Infection on Pregnancy and Neonatal Outcomes: An Observational Study

Cited by 2 publications

References 0 publications

ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections

ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections

Trasplante de microbiota fecal por colonoscopía en una mujer embarazada con infección recurrente por Clostridioides difficile

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