The Effect of Cisapride in Maintaining Symptomatic Remission in Patients with Gastro-Oesophageal Reflux Disease

Abstract

The study indicates that cisapride is of limited value in maintenance therapy of GORD in patients in whom symptom relief has been accomplished with potent antisecretory medication. This 'step-down' approach to therapy seems disadvantageous in the long-term therapy of GORD.

Heartburn treatment in primary care: randomised, double blind study for 8 weeks

“…Barrett's oesophagus was defined as intestinal metaplasia extending for more than 3 cm into the oesophagus. Gastric Helicobacter pylori infection was diagnosed with a rapid urease test (Helicobacter Urease Test, Astra, Germany), read after 24 hours In three networks, consecutive patients had 24 hour intraoesophageal pH-metry as previously described,8 after stopping treatment for more than 1 week. These results were not shown to the investigators or patients.…”

Nonerosive reflux disease (NERD) and functional dyspepsia

“…In einer großen europäischen Studie zeigte etwa die Hälfte der NERD-Patienten unter Cisaprid (Prokinetikum der ersten Generation; Agonist an den 5-HT 4 -und ein Antagonist an den 5-HT 3 -Rezeptoren) eine Remission [31]. Im Jahr 2000 musste die Zulassung des Medikamentes jedoch aufgrund von Nebenwirkungen zurückgenommen werden.…”

Review article: gastric acidity − comparison of esomeprazole with other proton pump inhibitors

“…Prokinetic drugs, at the present state of development, have been ineffective in GERD therapy. 1,2 Pharmacological suppression of gastric acidity has proved effective in symptom control and healing of reflux oesophagitis, and particularly so after the introduction of omeprazole and later proton pump inhibitors. In some countries, four different proton pump inhibitors (omeprazole, lansoprazole, pantoprazole and rabeprazole) have been available for routine prescription to patients.…”