The effect of cilengitide in combination with irradiation and chemotherapy in head and neck squamous cell carcinoma cell lines

Heiduschka, Gregor; Lill, Claudia; Schneider, Sven; Seemann, Rudolf; Kornek, Gabriela; Schmid, Rainer; Kotowski, Ulana; Thurnher, Dietmar

doi:10.1007/s00066-014-0600-x

Cited by 22 publications

(24 citation statements)

References 34 publications

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“…The most prominent compound targeting integrins might be cilengitide, a cyclic RGD peptide that targets integrins αvβ3 and αvβ5 [214]. We and other groups could show in vitro and in vivo that this peptide inhibits attachment and invasion of different tumor cells [215,216,217,218,219,220,221]. However, cilengitide failed to provide benefit in a clinical trial phase III (CENTRIC study) [222].…”

Section: Hotspots For Anticancer Treatmentmentioning

confidence: 99%

Integrins in the Spotlight of Cancer

Bianconi

Unseld

Prager

2016

IJMS

130

110

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Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands depending on their composition and regulate all processes which enable multicellular life. In cancer, integrins trigger and play key roles in all the features that were once described as the Hallmarks of Cancer. In this review, we will discuss the contribution of integrins to these hallmarks, including uncontrolled and limitless proliferation, invasion of tumor cells, promotion of tumor angiogenesis and evasion of apoptosis and resistance to growth suppressors, by highlighting the latest findings. Further on, given the paramount role of integrins in cancer, we will present novel strategies for integrin inhibition that are starting to emerge, promising a hopeful future regarding cancer treatment.

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Section: Hotspots For Anticancer Treatmentmentioning

confidence: 99%

Integrins in the Spotlight of Cancer

Bianconi

Unseld

Prager

2016

IJMS

130

110

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“…Clonogenic assays were performed as previously described (12). Briefly, 3-15x10 2 cells were seeded into 6-well plates and allowed to settle for 24 h. Afterwards, the cells were exposed to 5-20 µM TQ and/or irradiated with 2, 4, 6 or 8 Gy.…”

Section: Studymentioning

confidence: 99%

Effect of thymoquinone on head and neck squamous cell carcinoma cells in vitro: Synergism with radiation

et al. 2017

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Abstract. Thymoquinone (TQ) is the main bioactive constituent present in black seed oil (Nigella sativa); it has shown anti-inflammatory and anti-neoplastic effects in various cancer cell types. The aim of the present study was to investigate the effects of TQ on head and neck squamous cell carcinoma (HNSCC) cell lines, on its own and in combination with radiation and cisplatin, respectively. The SCC25 and CAL27 HNSCC cell lines were treated with TQ alone and in combination with cisplatin or radiation, respectively. Proliferation assays and clonogenic assays were performed. Apoptosis was detected by flow cytometry. TQ exhibited dose-dependent cytotoxicity via apoptosis in the investigated cell lines. In combination with cisplatin, TQ resulted in no significant increase in cytotoxicity. Combined with radiation, TQ significantly reduced clonogenic survival compared with each treatment method alone. TQ is a promising agent in the treatment of head and neck cancer due to its anti-proliferative and radiosensitizing properties. However, the combination of TQ with cisplatin showed no therapeutic benefit in vitro.

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“…Cilengitide in combination with irradiation gave significant inhibition of colony formation [74]. In ex vivo experiments, cilengitide alone had insignificant effect on colony formation from biopsies of HNSCC [75], although the same group later found it did significantly reduce colony formation when cells were seeded on laminin [76].…”

Section: Integrins In Hnsccmentioning

confidence: 99%

RGD-Binding Integrins in Head and Neck Cancers

Ahmedah

Patterson

Shnyder

et al. 2017

Cancers

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Alterations in integrin expression and function promote tumour growth, invasion, metastasis and neoangiogenesis. Head and neck cancers are highly vascular tumours with a tendency to metastasise. They express a wide range of integrin receptors. Expression of the αv and β1 subunits has been explored relatively extensively and linked to tumour progression and metastasis. Individual receptors αvβ3 and αvβ5 have proved popular targets for diagnostic and therapeutic agents but lesser studied receptors, such as αvβ6, αvβ8, and β1 subfamily members, also show promise. This review presents the current knowledge of integrin expression and function in squamous cell carcinoma of the head and neck (HNSCC), with a particular focus on the arginine-glycine-aspartate (RGD)-binding integrins, in order to highlight the potential of integrins as targets for personalised tumour-specific identification and therapy.

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The effect of cilengitide in combination with irradiation and chemotherapy in head and neck squamous cell carcinoma cell lines

Abstract: Cilengitide in combination with cisplatin and irradiation may be a feasible option for the treatment of patients with head and neck cancer. However, further investigations are required to understand the exact mechanism that leads to synergistic cytotoxicity.

Cited by 22 publications

References 34 publications

Integrins in the Spotlight of Cancer

Integrins in the Spotlight of Cancer

Effect of thymoquinone on head and neck squamous cell carcinoma cells in vitro: Synergism with radiation

RGD-Binding Integrins in Head and Neck Cancers

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