The effect of cigarette smoking on the clinical and serological phenotypes of polymyositis and dermatomyositis

Schiffenbauer, Adam; Faghihi-Kashani, Sara; O'Hanlon, Terrence P.; Flegel, Willy A.; Adams, Sharon; Targoff, Ira N.; Oddis, Chester V.; Ytterberg, Steven R.; Aggarwal, Rohit; Christopher‐Stine, Lisa; Shamim, Ejaz A.; Dellaripa, Paul F.; Danoff, Sonye K.; Mammen, Andrew L.; Miller, Frederick W.

doi:10.1016/j.semarthrit.2018.02.003

Cited by 37 publications

(22 citation statements)

References 42 publications

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“…In addition, current smoking status was found to be positively correlated with mortality. To our knowledge, smoking has been shown to be associated with autoantibody production as well as the development and course of many rheumatic disorders [26][27][28] . Smokers had a higher frequency of myositis-associated autoantibodies [28,29] .…”

Section: Discussionmentioning

confidence: 97%

“…To our knowledge, smoking has been shown to be associated with autoantibody production as well as the development and course of many rheumatic disorders [26][27][28] . Smokers had a higher frequency of myositis-associated autoantibodies [28,29] . A possible dose-response relationship existed between cigarette smoking and increasing risk of ILD in Caucasian PM/DM patients [28] .…”

Section: Discussionmentioning

confidence: 97%

“…Smokers had a higher frequency of myositis-associated autoantibodies [28,29] . A possible dose-response relationship existed between cigarette smoking and increasing risk of ILD in Caucasian PM/DM patients [28] . Our study provides evidence for the relationship of smoking status and risk of death.…”

Section: Discussionmentioning

confidence: 98%

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Comparison of Clinical Features and Prognostic Factors of Polymyositis/Dermatomyositis Associated Interstitial Lung Disease According to Autoantibodies: Anti-Aminoacyl tRNA Synthetase Antibodies Versus Anti-Melanoma Differentiation-Associated Gene 5 Antibody.

Gao

Yan

et al. 2020

Preprint

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Objective: The serum myositis-specific autoantibodies has been considered to be relatively specific and be useful for diagnosis of polymyositis/dermatomyositis associated interstitial lung disease (PM/DM-ILD). The goal of our retrospective study was to identify clinical features and prognostic factors for PM/DM-ILD based on serological phenotypes.Methods: PM/DM-ILD patients were diagnosed in the Department of Respiratory Medicine, Nanjing Drum Tower Hospital. MSAs were measured by anti-myositis antibody profile IgG detection kit. Based on the results of MSAs, the patients were divided into three groups: anti-MDA5 group, anti-Jo-1 group and other anti-ARS group. Kaplan-Meier, log rank, Kruskal-Wallis test and chi-square tests were used for analysis.Results: We identified 30 patients (22.0%) with positive anti-MDA5, 42 patients (31.0%) with positive anti-Jo-1 and 64 patients(47.0%) with other anti-ARS. acute disease onset was more frequently observed in the anti-MDA5 group (P = 0.005). The highest mortality rate was in the anti-MDA5 group (66.7%, P < 0.001). The overall survival of patients with anti-Jo-1 was significantly better than that of patients with anti-MDA5 (P < 0.001) and similar to that of patients with other anti-ARS. The acute disease onset (P = 0.002), DAD pattern for HRCT imaging (P < 0.001), current smokers (P = 0.02), presence of Anti-MDA5 (P < 0.001), fever (P < 0.001) were significantly associated with the mortality of the study population. Interestingly, in the subgroup survival analysis for anti-MDA5 group, age was a risk factor for death of patients with anti-MDA5 (P = 0.02), and the treatment with PSL pulse and IVIG were markedly correlated with high mortality (P < 0.001 and P = 0.001, respectively).Conclusion: Anti–MDA5 antibody is significantly associated with associated with worse prognosis in PM/DM-ILD patients. The application of PSL pulse and IVIG are not necessarily an effective treatment for positive anti-MDA5 patients.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

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Comparison of Clinical Features and Prognostic Factors of Polymyositis/Dermatomyositis Associated Interstitial Lung Disease According to Autoantibodies: Anti-Aminoacyl tRNA Synthetase Antibodies Versus Anti-Melanoma Differentiation-Associated Gene 5 Antibody.

Gao

Yan

et al. 2020

Preprint

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“…For example, the presence of the HLA-DRB1*03:01 allele in combination with smoking has been reported to significantly increase the risk of interstitial lung disease and polymyositis. 5 Of interest, the prevalence of dermatomyositis decreases the further away from the equator, 6 and this may be explained by exposure to UV light. 6 Furthermore, an association has been reported between the latitude-dependent development of dermatomyositis and myositis-specific (anti-Mi-2 and anti-TIF1-γ) antibodies.…”

Section: Origin Examplesmentioning

confidence: 99%

Management of the idiopathic inflammatory myopathies

Nadin¹,

Haque²,

Akil³

et al. 2019

Prescriber

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“…A number of studies have recently investigated risk factors for ILD. A recent study by Schiffenbauer et al [ 16 ] has highlighted important relationships between cigarette smoking, ILD risk and clinical and serological manifestations in the IIMs. White IIM cases who had ever smoked were more likely to have polymyositis and test positive for an antisynthetase or anti-Jo-1 autoantibodies; they were also less likely to test positive for antitranscriptional intermediary factor antibody.…”

Section: Interstitial Lung Diseasementioning

confidence: 99%

Recent developments in classification criteria and diagnosis guidelines for idiopathic inflammatory myopathies

Oldroyd

Chinoy

2018

Current Opinion in Rheumatology

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Purpose of reviewThe aim of this review was to summarize key developments in classification and diagnosis of the idiopathic inflammatory myopathies (IIMs).Recent findingsThe recently published European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for the IIMs provide a comprehensive, accurate and data-driven approach to identification of IIM cases appropriate for inclusion in research studies. Further, recent studies have advanced understanding of clinical manifestations of the IIMs and delineated the role of imaging, particularly magnetic resonance.SummaryThe recent publication of the EULAR/ACR classification criteria will potentially greatly improve IIM research through more accurate case identification and standardization across studies.Future inclusion of newly recognized clinical associations with the MSAs may further improve the criteria's accuracy and utility. Clear and comprehensive understanding of associations between clinical manifestations, prognosis and multisystem involvement can aid diagnostic assessment; recent advances include delineation of such associations and expansion of the role of imaging.

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The effect of cigarette smoking on the clinical and serological phenotypes of polymyositis and dermatomyositis

Abstract: Tobacco smoking was associated with clinical and autoantibody phenotypes in Caucasians. Our findings also suggest possible interactions among HLA-DRB1*03:01 and smoking on the risk of PM and ILD, as well as, anti-synthetase, anti-Jo-1, and anti-p155/140 autoantibodies in Caucasians.

Cited by 37 publications

References 42 publications

Comparison of Clinical Features and Prognostic Factors of Polymyositis/Dermatomyositis Associated Interstitial Lung Disease According to Autoantibodies: Anti-Aminoacyl tRNA Synthetase Antibodies Versus Anti-Melanoma Differentiation-Associated Gene 5 Antibody.

Comparison of Clinical Features and Prognostic Factors of Polymyositis/Dermatomyositis Associated Interstitial Lung Disease According to Autoantibodies: Anti-Aminoacyl tRNA Synthetase Antibodies Versus Anti-Melanoma Differentiation-Associated Gene 5 Antibody.

Management of the idiopathic inflammatory myopathies

Recent developments in classification criteria and diagnosis guidelines for idiopathic inflammatory myopathies

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