The Effect of Cigarette Smoking on Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Clair, Carole; Cohen, Marya J.; Eichler, Florian; Selby, Kevin; Rigotti, Nancy A.

doi:10.1007/s11606-015-3354-y

Cited by 121 publications

(98 citation statements)

References 70 publications

(19 reference statements)

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“…Surprisingly, a protective effect of smoking has been reported in US veterans [12]. More recently, a meta-analysis including 10 prospective and 28 cross-sectional studies has found that smoking had an unadjusted OR of 1.26 for prospectively developing DSPN (95% CI: 0.86-1.85) [59]. In the cross-sectional studies, the pooled OR for DSPN due to smoking was 1.42 (95% CI: 1.21-1.65) [48].…”

Section: Smokingmentioning

confidence: 99%

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Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

2015

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■ AbstractDistal symmetric sensorimotor polyneuropathy (DSPN) is the most common neurological manifestation in diabetes. Major risk factors of DSPN include diabetes duration, hyperglycemia, and age, followed by prediabetes, hypertension, dyslipidemia, and obesity. Height, smoking, insulin resistance, hypoinsulinemia, and others represent an additional risk. Importantly, hyperglycemia, hypertension, dyslipidemia, obesity, and smoking are modifiable. Stringent glycemic control has been shown to be effective in type 1, but not to the same extent in type 2 diabetes. Antilipidemic treatment, especially with fenofibrate, and multi-factorial intervention have produced encouraging results, but more experience is necessary. The major comorbidities of DSPN are depression, autonomic neuropathy, peripheral artery disease, cardiovascular disease, nephropathy, retinopathy, and medial arterial calcification. Knowledge of risk factors and comorbidities has the potential to enrich the therapeutic strategy in clinical practice as part of the overall medical care for patients with neuropathy. This article provides an updated overview of DSPN risk factors and comorbidities.

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Section: Smokingmentioning

confidence: 99%

“…In the cross-sectional studies, the pooled OR for DSPN due to smoking was 1.42 (95% CI: 1.21-1.65) [48]. For both analyses, evidence was graded as low-strength [59].…”

Section: Smokingmentioning

confidence: 99%

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

2015

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“…The odds of being a smoker were higher in patients who developed DPN. 1 This was observed in prospective studies that adjusted for covariates (HbA1c etc. ), that studied type 1 patients (n=3854), and that had a follow-up period of≥5 years.…”

mentioning

confidence: 78%

Capsule Commentary on Clair et al., The Effect of Cigarette Smoking on Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Mummadi

2015

J GEN INTERN MED

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“…[9,10] The studies show that smoking in the DM1 and DM2 patients is a risk factor for the development of microvascular complications like diabetic peripheral neuropathy (DPN). [11] Distal symmetric sensorimotor polyneuropathy (DSPN) is the most common neurological disorder in diabetes. [12] In another study focusing on the development of peripheral neuropathy in the DM2 patients, the risk of neuropathy development in the smoking patients was found higher.…”

Section: Discussionmentioning

confidence: 99%

The Evaluation of the Neuropathic Pain in the Smokers

Çelik¹

2017

Agri

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SummaryObjectives: Nicotine addiction is one of the most important causes of the general failure of treatment and keeping the habit of smoking. Peripheral neuropathy is a leading factor of smoking. This study aimed to analyze the association of neuropathic pain and addiction levels of individuals. Methods: The study was performed on the day on which the smokers visited the hospital for any reason. The Douleur Neuropathique 4 (DN-4) Scale and Fagerström Addiction Survey were administered to the individuals after obtaining their consent. Results: In total, 444 individuals were included in the study, and 57.2% of them were males (n = 254). The age average of the individuals with neuropathic pain (46.4±12.3 years) was significantly higher than that of those without pain. The individuals with pain smoked approximately 31.8±18.3 packet/year cigarettes, whereas those without pain smoked approximately 22.4 ± 15.5 packet/year cigarettes; the difference was significant statistically (p<0.05). According to multivariate logistic regression analysis with the backward elimination method, the existence of pain was found to be PR = 2.22 (95% GA, 1.26-3.91) in terms of sex, DM existence was found to be PR = 1.97 (95% GA, 1.02-3.81), and for each standard deviation increase (2.7) in Fagerström scale, PR was 1.29 (95% GA, 1.14-1.46). Conclusion:Smoking is a risk factor for neuropathic pain. In our study, the possibility of neuropathic pain increases as the duration of smoking and addiction level increase, and with diabetes, this rate increases even more. It is extremely important that the smokers should be informed regarding these facts and possibilities.

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The Effect of Cigarette Smoking on Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis

Cited by 121 publications

References 70 publications

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015

Capsule Commentary on Clair et al., The Effect of Cigarette Smoking on Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis

The Evaluation of the Neuropathic Pain in the Smokers

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