The effect of cicloxolone sodium on the replication of vesicular stomatitis virus in BSC-1 cells

The effect of cicloxolone sodium on the replication in cultured cells of adenovirus type 5, reovirus type 3, poliovirus type 1, two bunyaviruses and Semliki Forest virus

“…The presence of CCX or Mon in the culture medium of infected cells impairs the transport of both VSV (Dargan et al, 1992) and SFV (this paper) glycoproteins through the Golgi apparatus, but the outcomes are quite different. With VSV the result is greatly reduced assembly of particles at the plasma membrane, whereas SFV assembly is relocated from the plasma membrane to internal vesicles.…”

“…Gait et al (1990) placed viruses representing eight different virus families into three CCX sensitivity (CCX ~) classes based on the different kinetics of dose-response curves. We have studied, in some depth, the antiviral mechanism of CCX operating against the replication of the CCXs-1 viruses, herpes simplex virus types 1 and 2 (HSV-1 and -2) (Dargan & Subak-Sharpe 1985, 1986, 1991Dargan et al, 1988) and vesicular stomatitis virus (VSV) (Dargan et al, 1992). Here we investigate the effects of CCX on the replication of viruses belonging to the CCXs-2 and CCXs-3 classes.…”

“…CCX and monensin (Mon) have been shown to have analagous effects on the replication of HSV and VSV, and functions associated with the Golgi apparatus, e.g. post-translational processing of glycoproteins and their intracellular transport (Dargan & Subak-Sharpe, 1986, 1991Dargan et al, 1992). Thus the Mon-like effect of CCX on the replication of different viruses can be related to the importance of Golgi apparatus functions for the replication of particular viruses.…”

Synthesis, transformation and biological evaluation of 2,3-secotriterpene acetylhydrazones and their derivatives

“…Oleanane triterpenoids, glycyrrhetinic acid and its semi-synthetic derivative cicloxolone have been found to possess an inhibitory effect (up to 300 mM) at all stages of the VSV replication cycle [2,3]. Betulin and betulinic acid, lupane triterpenoids, have been reported as very active compounds with the antiviral activities of up to 1e1.2 mg/mL [4].…”

Prospects for the creation of new antiviral drugs based on glycyrrhizic acid and its derivatives (a review)

“…Derivatives of II, cycloxolone and X, exhibited antiviral activity against HSV-1 by inhibiting production of virus particles but, mainly, by severely damaging virion progenes [152,153]. The anti-HIV effect of II was also due to selective inhibition of HIV-1 RT casein kinase II at the cellular level [140].…”