The effect of chronic kidney disease on lipid metabolism

Dinçer, Neris; Dağel, Tuncay; Afsar, Barış; Covic, Adrian; Ortíz, Alberto; Kanbay, Mehmet

doi:10.1007/s11255-018-2047-y

Cited by 38 publications

(36 citation statements)

References 149 publications

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“…ALT level was significantly increased by about 62% in the FVO group compared to the control RVO group, while raw veg- lipid (Jordy et al, 2015;van der Windt et al, 2018). and induces the progression rate of kidney disease, glomerulosclerosis (Dincer et al, 2019;Islam et al, 2019). In our present study, the serum lipid profile of repeatedly deep-fried vegetable oil consumed rats showed significant hypercholesterolemia compared to raw oil-fed rats.…”

Section: Discussionsupporting

confidence: 52%

“…Dyslipidemia may contribute to the progression of kidney diseases which leads to renal injury with macrophage accumulation in the glomerulus of the kidney (Van Der Heijden et al., 2015). Studies found that diet with high‐fat content causes hypercholesterolemia and induces the progression rate of kidney disease, glomerulosclerosis (Dincer et al., 2019; Islam et al., 2019). In our present study, the serum lipid profile of repeatedly deep‐fried vegetable oil consumed rats showed significant hypercholesterolemia compared to raw oil‐fed rats.…”

Section: Discussionmentioning

confidence: 99%

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Remedial role of exercise training to deep‐fried oil‐induced metabolic and histological changes in Wistar rats

et al. 2020

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Remedial role of exercise training to deep‐fried oil‐induced metabolic and histological changes in Wistar rats

et al. 2020

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“…Therefore, it is reasonable to speculate that PNPLA3 expression in the kidneys might also be stimulated under conditions of lipid excess and then increase ectopic lipid accumulation in renal mesangial and tubular cells. In addition, renal lipotoxicity can also promote kidney tubular impairment, abnormal albuminuria and glomerulosclerosis, thus causing a progressive decline in kidney function (33)(34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

PNPLA3 rs738409 is associated with renal glomerular and tubular injury in NAFLD patients with persistently normal ALT levels

Sun

Zheng

et al. 2019

Liver International

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Background & Aim: Patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 polymorphism is associated with NAFLD severity and the PNPLA3 gene is expressed in the kidneys,but whether PNPLA3 rs738409 polymorphism is also associated with renal tubular injury is uncertain. We assessed the effect of PNPLA3 genotypes on biomarkers of renal tubular injury (RTI) and glomerular function in subjects with NAFLD who had either normal (nALT) or abnormal (abnALT) alanine aminotransaminase levels. Methods: 217 patients with histologically-proven NAFLD, of which 75 had persistently nALT (below upper limit of normal for 3 months) were included. Multivariable regression analyses were undertaken to test associations between PNPLA3 genotype and biomarkers of kidney dysfunction. Results: The nALT patient group had higher urinary neutrophil gelatinase-associated lipocalin levels (u-NGAL, a biomarker of RTI) (P <0.001), higher albuminuria (P =0.039) and greater prevalence of chronic kidney disease (CKD) (P =0.046) than the abnALT group. The association between PNPLA3 GG genotype and risk of CKD and abnormal albuminuria remained significant after adjustment for kidney risk factors and severity of NAFLD histology, mostly in the nALT group. Similarly, PNPLA3 GG 6 genotype was associated with higher u-NGAL levels in the nALT group, even after adjustment for the aforementioned risk factors and glomerular filtration-based markers (β-coefficient: 22.29, 95% CI: 0.99-43.60, P =0.041). Conclusion: Patients with NAFLD and persistently nALT, who carry the PNPLA3 rs738409 G allele, are at higher risk of early glomerular and tubular damage. We suggest PNPLA3 genotyping may help identify patients with NAFLD at higher risk of RTI.

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“…Several agents have been designed to regulate lipid profile such as statins, niacin, fibrates, ezetimibe, fish oil/omega-3, [31][32][33][34]. So far, a number of studies have confirmed that statins are effective in lowering serum lipids and improving the cardiovascular risk compared to all other classes of medicines used in renal transplant patients [35].…”

Section: Biomed Research Internationalmentioning

confidence: 99%

Effects of Statins on Lipid Profile of Kidney Transplant Recipients: A Meta-Analysis of Randomized Controlled Trials

Huang

Jia

Zhu

et al. 2020

BioMed Research International

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Objective. To assess the benefits of statins on lipid profile in kidney transplant recipients via a meta-analysis. Methods. We systematically identified peer-reviewed clinical trials, review articles, and treatment guidelines from PubMed, Embase, the Cochrane Library, Wanfang, Chinese National Knowledge Infrastructure (CNKI), SinoMed (CBM), and Chongqing VIP databases from inception to April 2019. In the analysis, only randomized controlled clinical trials performed in human were included. Results. Eight articles were included in the analysis, involving 335 kidney transplant recipients who received statins and 350 kidney transplant patients as the control group. Results revealed that statins improved the lipid profile of kidney transplant recipients. Specifically, statin therapy significantly reduced total cholesterol and low-density lipoprotein cholesterol. However, it had no effects on high-density lipoprotein cholesterol and triglyceride levels. Conclusions. The present study provides valuable knowledge on the potential benefits of statins in kidney transplant recipients. This meta-analysis shows that statin therapy modifies the lipid profile in this patient population.

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The effect of chronic kidney disease on lipid metabolism

Cited by 38 publications

References 149 publications

Remedial role of exercise training to deep‐fried oil‐induced metabolic and histological changes in Wistar rats

Remedial role of exercise training to deep‐fried oil‐induced metabolic and histological changes in Wistar rats

PNPLA3 rs738409 is associated with renal glomerular and tubular injury in NAFLD patients with persistently normal ALT levels

Effects of Statins on Lipid Profile of Kidney Transplant Recipients: A Meta-Analysis of Randomized Controlled Trials

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