The effect of chronic cocaine administration on hemodynamic stability and neurohumoral mediators during isoflurane anesthesia and shock in rats

Mets, Berend; Pantuck, Carol B.; Diaz, Julia M.; Soo, E.

doi:10.1034/j.1399-6576.2001.045003377.x

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…Isoflurane has also been shown to induce vasodilation (Du et al, 2009) and thus it is possible that it might have attenuated cocaine induced reductions in blood supply. However, since prior cocaine exposure history does not appear to interact with isoflurane effects (Mets et al, 2001;Bernards et al, 1997),…”

Section: Discussionmentioning

confidence: 98%

Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized rats

Allen

Park

et al. 2018

Addiction Biology

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Cocaine addiction is associated with dysfunction of the prefrontal cortex (PFC), which facilitates relapse and compulsive drug taking. To assess if cocaine's effects on both neuronal and vascular activity contribute to PFC dysfunction, we used optical coherence tomography and multi-wavelength laser speckle to measure vascularization and hemodynamics and used GCaMP6f to monitor intracellular Ca levels ([Ca ] ) as a marker of neuronal activity. Rats were given short (1 hour; ShA) or long (6 hours; LgA) access cocaine self-administration. As expected, LgA but not ShA rats escalated cocaine intake. In naïve rats, acute cocaine decreased oxygenated hemoglobin, increased deoxygenated hemoglobin and reduced cerebral blood flow in PFC, likely due to cocaine-induced vasoconstriction. ShA rats showed enhanced hemodynamic response and slower recovery after cocaine, versus naïve. LgA rats showed a blunted hemodynamic response, but an enhanced PFC neuronal [Ca ] increase after cocaine challenge associated with drug intake. Both ShA and LgA groups had higher vessel density, indicative of angiogenesis, presumably to compensate for cocaine's vasoconstricting effects. Cocaine self-administration modified the PFC cerebrovascular responses enhancing it in ShA and attenuating it in LgA animals. In contrast, LgA but not ShA animals showed sensitized neuronal reactivity to acute cocaine in the PFC. The opposite changes in hemodynamics (decreased) and neuronal responses (enhanced) in LgA rats indicate that these constitute distinct effects and suggest that the neuronal and not the vascular effects are associated with escalation of cocaine intake in addiction whereas its vascular effect in PFC might contribute to cognitive deficits that increase vulnerability to relapse.

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Section: Discussionmentioning

confidence: 98%

Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized rats

Allen

Park

et al. 2018

Addiction Biology

View full text Add to dashboard Cite

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Prenatal cocaine administration increases glutathione and alpha-tocopherol oxidation in fetal rat brain

Lipton

Gyawali

Borys

et al. 2003

Developmental Brain Research

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Prenatal cocaine exposure induces an attenuation of uterine blood flow in the rat

Lipton

Ling

et al. 2002

Neurotoxicology and Teratology

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The effect of chronic cocaine administration on hemodynamic stability and neurohumoral mediators during isoflurane anesthesia and shock in rats

Abstract: These data suggest that chronic cocaine treatment in rats does not impair endogenous vasoconstrictor secretion nor alter the heart rate and blood pressure response to isoflurane and blood loss.

Cited by 4 publications

References 24 publications

Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized rats

Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized rats

Prenatal cocaine administration increases glutathione and alpha-tocopherol oxidation in fetal rat brain

Prenatal cocaine exposure induces an attenuation of uterine blood flow in the rat

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