The Effect of Chromium Picolinate Supplementation on the Pancreas and Macroangiopathy in Type II Diabetes Mellitus Rats

Abstract

Purpose. The aim was to explore the effect of the chromium picolinate (CrPic) administration on the pancreas and macroangiopathy of type II diabetes mellitus rats. Methods. The type II diabetes mellitus (T2DM) rat model was induced by low-dose streptozotocin (STZ). The rats were randomly divided into 5 groups (ten rats in each group). After supplementing CrPic for 15 weeks, the histopathological examination was performed by hematoxylin-eosin (HE) staining. Serum insulin and NO level were determined by radioimmunoassay and colorimetry, respectively. Serum glycosylated hemoglobin (HbA1C), adiponectin (APN), advanced glycation end products (AGES), and apelin were measured by ELISA. Real-time reverse transcription polymerase chain reaction (RT-PCR) was applied for detecting the mRNA expression of APN and apelin. Results. After CrPic treatment, compared with the T2DM control group (group 2), pancreas sections stained with HE showed the completed pancreatic cells structure and no inflammatory infiltration in groups 4 and 5. In addition, the levels of serum NO and insulin were significantly increased and the serum levels of HbA1C, AGES, APN, and apelin were significantly decreased in groups 4 and 5 compared with group 2. The mRNA expression of APN and apelin in groups 4 and 5 was also recovered to the normal level. Conclusion. CrPic can recover the function of Β-cells and alleviate macroangiopathy in STZ-induced T2DM rats.

Pi-Dan-Jian-Qing Decoction Ameliorates Type 2 Diabetes Mellitus Through Regulating the Gut Microbiota and Serum Metabolism

“…The pathological results showed that the hepatocytes in the liver of the T2DM group rats were disordered, enlarged, and had deformation of vacuolated balloon; the pancreatic islets in the pancreas were sparsely distributed and vacuolated; the smooth muscle layer of the colon was thinned and the number of myocytes was reduced; the glomeruli in the kidney tissue were swollen and enlarged; the epithelial cells of the renal tubules were swollen or detached; the renal interstitium was infiltrated with inflammatory cells; and mesangial proliferation and interstitial fibrosis were also observed. The above results are consistent with the pathological manifestations of T2DM ( Huang et al., 2014 ; Fan et al., 2018 ). The intervention of PDJQ can reduce blood glucose and improve dyslipidemia, IR, and pathological changes of kidney, liver, pancreas, and colon tissues in T2DM rats.…”

Effects of chromium picolinate on fat deposition, activity and genetic expression of lipid metabolism-related enzymes in 21 day old Ross broilers

“…Studies have shown that Cr can improve glycometabolism and lipid metabolism in diabetes mellitus [ 29 – 31 ], due to its role in glucose/insulin metabolism [ 32 ]. Previous studies also indicated that Cr could affect lipid metabolism and reduce body fat deposition of broilers [ 18 , 28 , 33 ].…”

Antidiabetic and hypolipidemic effects of adropinin streoptozotocin-induced type 2 diabetic rats

“…In the study by Mahmoud et al (13), it was observed that type 2 diabetic rats exhibited a signifi cantly elevated fasting blood glucose and HOMA-IR, accompanied with diminished serum insulin levels, and insulin resistance has developed in these animals (13). Huang et al (14) reported that HbA1c (%) levels, the indicator of diabetes, were signifi cantly increased in type 2 diabetes mellitus rats (14). Estimation of HbA1c% has been found to be particularly useful in monitoring the effectiveness of therapy in diabetes (15).…”