The Effect of Chinese Traditional Medicine Huaiqihuang (HQH) on the Protection of Nephropathy

Abstract

Kidney disease is one of the common diseases with high morbidity and high mortality, which brings a huge burden to the society and the patient’s family. The pathogenesis, treatment, and prognosis of kidney diseases are related to oxidative stress, inflammation, mitochondrial damage, and immune dysfunction. However, existing treatments always cause some damage to the kidneys. Kidney disease and immunosuppressant used together often lead to drug toxicity, patients with weakened immunity, organic rupture of the normal structure of the kidney, damage to the physiological function of the kidney, etc. Huaiqihuang is a kind of traditional Chinese medicine with a history of more than one thousand years. According to research, Robinia pseudoacacia can regulate the immune function by regulating oxidative stress, calcium inflow, and mitochondrial ATP. At the same time, it is also involved in regulating the ways of cell death, such as apoptosis, autophagy, ferroptosis, pyroptosis, and clockophagy, to reduce kidney damage, which has important clinical value. This article reviews the exact mechanism and clinical application of Huaiqihuang in different types of nephropathy. The aim is to provide new ideas for the treatment of clinical nephropathy.

Effect of Huaiqihuang Granules Combined with Comprehensive Nursing on Children with Primary Nephrotic Syndrome

“…PNS belongs to the category of “edema” and “consumptive” in TCM, and its occurrence is caused by deficiency of lung, spleen, and kidney [ 6 ]. Huaiqihuang granules are composed of Huaier fungus, Lycii Fructus, and Polygonati Rhizoma, and have the effect of nourishing Qi and nourishing Yin.…”

“…From the perspective of TCM, PNS is classified into “edema” and “asthenia,” and it is believed that the occurrence of PNS is caused by spleen deficiency and kidney deficiency. Huaiqihuang granules has the effect of nourishing Qi and Yin and can reduce proteinuria and protect renal function with its adjuvant treatment of PNS, which has synergistic effect with hormone and immunosuppression [ 6 ]. In addition, due to the younger age of children, there will inevitably be mood fluctuations in the treatment process, affecting the treatment effect.…”

A Review of Traditional Chinese Medicine in Treating Renal Interstitial Fibrosis via Endoplasmic Reticulum Stress-Mediated Apoptosis

“…The formula consists of the fungus trametes, goji berry ( Lycium barbarum L.), and polygonatum rhizome ( Polygonatum sibiricum F.Delaroche), which have long been used in China to treat kidney disease. Research has shown that mechanisms by which they exert their effects include regulating oxidative stress and inhibiting apoptosis [ 93 ]. Other studies have shown that the formula protects podocytes by suppressing the p-ERK/CHOP signaling pathway and reversing mercury-induced upregulation of GRP78 and reducing dysfunction of podocyte apoptosis and DNA damage [ 74 , 75 ].…”

Chinese patent herbal medicine Huaiqihuang for Henoch-Schonlein purpura nephritis in children: a systematic review of randomized controlled trials

“…All ingredients of HQH were shown in Table 1. All of these have been extensively used in China for thousands of years [8]. In recent years, HQH granules have been widely applied in the clinical treatment of various chronic kidney disease, including primary nephrotic syndrome, IgA nephropathy, HSPN and other primary and secondary kidney diseases [9][10][11][12][13].…”