The Effect of Chinese Medicinal Herbs in Relieving Menopausal Symptoms in Ovariectomized Chinese Women

Zhou, Jue; Qu, Fan; Nan, Rui; Tang, Daiyi

doi:10.1016/j.explore.2007.06.002

Cited by 8 publications

(34 citation statements)

References 23 publications

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“…[2][3][4][5] In addition, Chinese herbs may be used as an alternative treatment for ovariectomized women suffering from menopausal symptoms, who are either unable or unwilling to receive HRT. 6) Furthermore, Chinese herbs have demonstrated synergistic effects with tamoxifen on reducing serum hormone levels, but have been shown to alleviate endometrial hypertrophy as well, which is a side effect of tamoxifen. 7) In animal experiments, it has been reported that Chinese medicinal formulas or Chinese herb extracts or a single herb were effective in treating and preventing osteoporosis in ovariectomized rats, yet produced no adverse reactions in stimulating the proliferation and hypertrophy of body weight and the uterus.…”

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confidence: 99%

You Gui Wan Can Reverse Atrophic Effect of Ovariectomy on Rat Vaginal Fold and Blood Vessels in the Lamina Propria

Wang

Yin

et al. 2011

Biological & Pharmaceutical Bulletin

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The aim of this study is to investigate whether or not You Gui Wan (YGW), a classical herbal formula in Traditional Chinese Medicine (TCM), has an impact on rat uterine and vaginal atrophic processes induced by ovariectomy (OVX). Thirty-four OVX Sprague-Dawley (SD) rats were randomly divided into three sets, and orally administrated with YGW decoction, saline or estrogen for 11 weeks, respectively. Histomorphological changes of the uterus and vagina, and serum estradiol levels were then compared. Results showed that OVX caused a dramatic atrophy of the uterus and vagina in the rats. Estrogen replacement reversed the effect of OVX, but with a side effect of endometrial hyperplasia. YGW had no significant effect on blood estradiol concentration or uterine histology, but it significantly overturned the atrophic processes of the vaginal fold and blood vessels in the lamina propria. In order to initially explore the mechanisms underlying these effects, immunostaining of estrogen receptor (ER)-a a and -b b in the vagina was performed. It was shown that OVX reduced expressions of ER while YGW and estrogen replacement reversed this reduction. Our findings suggest that YGW can reverse the atrophic effect of OVX on rat vaginal plica and blood vessels in the lamina propria with little adverse effect on endometrial hyperplasia. This indicates the herbal formula as an alternative to hormone replacement therapy in the management of menopausal vaginal atrophy. Recovery of ER expressions in the vagina might be one of mechanisms underlying the effects of YGW.

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confidence: 99%

You Gui Wan Can Reverse Atrophic Effect of Ovariectomy on Rat Vaginal Fold and Blood Vessels in the Lamina Propria

Wang

Yin

et al. 2011

Biological & Pharmaceutical Bulletin

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“…Twenty-two parallel-design randomised controlled trials (RCTs) were included in the review (Azizi 2011; Deng 2011; Gong 2008; Guo 2009; Haines 2008; Jing 2002; Kwee 2007; Li 2009; Liang 2003; Lou 2009; Plotnikoff 2011; Qu 2009; Tao 2009; van der Sluijs 2009; Wu 2013; Xia 2012; Xue 2011; Zhang 2009; Zhang 2012; Zhong 2013; Zhou 2007; Zhou 2009). All were single-centre studies with three studies conducted in outpatient clinics in Australia (van der Sluijs 2009), The Netherlands (Kwee 2007) and the USA (Plotnikoff 2011).…”

Section: Resultsmentioning

confidence: 99%

“…Bai Shao Yao Radix Paeoniae Alba (eight studies) (Azizi 2011; Jing 2002; Plotnikoff 2011; Wu 2013; Xue 2011; Zhang 2012; Zhou 2007; Zhou 2009). …”

Section: Resultsmentioning

confidence: 99%

“…Dang Gui Radix Angelicae Sinensis (seven studies) (Azizi 2011; Haines 2008; Jing 2002; Wu 2013; Zhang 2009; Zhong 2013; Zhou 2007). …”

Section: Resultsmentioning

confidence: 99%

“…The most popular form of CHM was herbal extract in the form of granules which was used in 17/22 studies (Azizi 2011; Deng 2011; Gong 2008; Haines 2008; Jing 2002; Kwee 2007; Li 2009; Liang 2003; Lou 2009; Plotnikoff 2011; Tao 2009; van der Sluijs 2009; Xia 2012; Xue 2011; Zhong 2013; Zhou 2007; Zhou 2009); only five studies used a traditional form as a decoction (Guo 2009; Qu 2009; Wu 2013; Zhang 2009; Zhang 2012. All herbs were administered internally.…”

Section: Resultsmentioning

confidence: 99%

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