The effect of changing oxygen saturation protocols on the incidence of laser treatment for retinopathy of prematurity

Wiwatwongwana, Atchareeya; Kersey, James P.; Gardiner, Joseph

doi:10.3129/i10-058

Cited by 5 publications

(8 citation statements)

References 26 publications

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“…2009; Tokuhiro et al. 2009; SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network 2010; Wiwatwongwana et al. 2010), although some studies have failed to establish such a correlation (Deulofeut et al.…”

Section: Pathological Retinal Developmentmentioning

confidence: 99%

“…The relationship between oxygen supply and ROP has been well known since the 1950s (Campbell 1951;Patz et al 1952;Ashton et al 1953;Kinsey 1956;Patz & Eastham 1957). Furthermore, several retrospective and prospective studies on the restrictive use of oxygen have revealed a decrease in the incidence and severity of ROP (Tin et al 2001;Chow et al 2003;Anderson et al 2004;VanderVeen et al 2006;Wright et al 2006;Sears et al 2009;Tokuhiro et al 2009; SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network 2010; Wiwatwongwana et al 2010), although some studies have failed to establish such a correlation (Deulofeut et al 2006;Wallace et al 2007;Tlucek et al 2010). Low oxygen saturation might appear to reduce the risk of severe ROP when carefully controlled within the first weeks of life, but the optimal level of saturation remains uncertain.…”

Section: Pathological Retinal Developmentmentioning

confidence: 99%

See 1 more Smart Citation

The pathophysiology of retinopathy of prematurity: an update of previous and recent knowledge

Cavallaro

Filippi

Bagnoli

et al. 2013

Acta Ophthalmologica

159

142

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ABSTRACT.Retinopathy of prematurity (ROP) is a disease that can cause blindness in very low birthweight infants. The incidence of ROP is closely correlated with the weight and the gestational age at birth. Despite current therapies, ROP continues to be a highly debilitating disease. Our advancing knowledge of the pathogenesis of ROP has encouraged investigations into new antivasculogenic therapies. The purpose of this article is to review the findings on the pathophysiological mechanisms that contribute to the transition between the first and second phases of ROP and to investigate new potential therapies. Oxygen has been well characterized for the key role that it plays in retinal neoangiogenesis. Low or high levels of pO 2 regulate the normal or abnormal production of hypoxia-inducible factor 1 and vascular endothelial growth factors (VEGF), which are the predominant regulators of retinal angiogenesis. Although low oxygen saturation appears to reduce the risk of severe ROP when carefully controlled within the first few weeks of life, the optimal level of saturation still remains uncertain. IGF-1 and Epo are fundamentally required during both phases of ROP, as alterations in their protein levels can modulate disease progression. Therefore, rhIGF-1 and rhEpo were tested for their abilities to prevent the loss of vasculature during the first phase of ROP, whereas anti-VEGF drugs were tested during the second phase. At present, previous hypotheses concerning ROP should be amended with new pathogenetic theories. Studies on the role of genetic components, nitric oxide, adenosine, apelin and b-adrenergic receptor have revealed new possibilities for the treatment of ROP. The genetic hypothesis that single-nucleotide polymorphisms within the b-ARs play an active role in the pathogenesis of ROP suggests the concept of disease prevention using b-blockers. In conclusion, all factors that can mediate the progression from the avascular to the proliferative phase might have significant implications for the further understanding and treatment of ROP.Key words: erythropoietin -hypoxia-inducible factor 1 -insulin-like growth factor-1 -neovascularization -pathophysiology -placental growth factor -retinopathy of prematurity -vascular endothelial growth factor -b-adrenergic receptors Acta Ophthalmol. 2014: 92: 2-20

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Section: Pathological Retinal Developmentmentioning

confidence: 99%

Section: Pathological Retinal Developmentmentioning

confidence: 99%

The pathophysiology of retinopathy of prematurity: an update of previous and recent knowledge

Cavallaro

Filippi

Bagnoli

et al. 2013

Acta Ophthalmologica

159

142

View full text Add to dashboard Cite

show abstract

“…The work has concentrated more on the incidence and severity of ROP, and not on the temporal profile of the disease. [2][3][4][5][6][7][8][9][10][11] Previous work from this institution has suggested that a lower oxygen saturation target does is not directly related to the mean postmenstrual age of onset of ROP (35.2 weeks in the higher target cohort versus 34.8 weeks in the lower, P 5 0.1083). 12 A change in the prevalence of type 1 ROP corresponding to a change in oxygen protocol would suggest that the biologic behavior of the disease has been altered in some way.…”

Section: Resultsmentioning

confidence: 99%

“…1 Thus, in recent work investigators have focused on potential prophylactic measures to minimize the incidence and severity of disease, with particular attention to maintaining a more strictly monitored, lower-oxygen saturation target. [2][3][4][5][6][7][8][9][10][11][12] However, recent prospective studies have encouraged caution in this regard because of an unexpected increase in mortality with the implementation of a stricter protocol. 9,13 Although these studies, in aggregate, suggest a correlation between a lower-oxygen saturation target and a decreased incidence and severity of ROP, they do not describe other effects it may have on the biologic behavior of the disease, an example of which is its postmenstrual age of onset.…”

mentioning

confidence: 99%

Effect of the oxygen saturation target on clinical characteristics of early- versus late-onset retinopathy of prematurity

Tlucek

Grace

Anderson

et al. 2012

Journal of American Association for Pediatric Ophthalmology and

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“…Bununla birlikte mortalite üzerinde, PR'ye bağlı körlüklerde, kronik akciğer hastalıklarında ve beyin hasarı oluşmasında risk faktörü oluşturmaktadır. Sonuç olarak prematüre bebekler oksijenin toksik etkilerinden daha fazla etkilenmektedir (22) .…”

Section: Prematüre Reti̇nopati̇si̇ Ve Hemşi̇reli̇k Bakimiunclassified

Regression of Malignant Melanoma which Occured in the Basis of a Nevus: Case Report

Erdogan¹,

Çakır²,

Yarıkkaya³

et al. 2014

Okmeydani Medical Journal

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ÖZETPrematüre retinopatisi (PR), gebeliğin üçüncü trimesterinde ya da öncesinde doğan bebeklerde, retinanın normal vaskülarizasyonunun tamamlanamaması ya da anormal damarlanması ile karakterize bir hastalık-tır (1) . Prematüre retinopatisinin etiyolojisi ve patogenezi tam olarak bilinmemekle birlikte çocukluk çağı önlenebilir körlük nedenleri arasında ilk sıralarda yer almaktadır (2) . Dünyada 50.000 çocukta PR nedeniyle körlük, daha fazlasında ciddi görme bozuklukları olduğu; PR gelişen çocuklarda körlük insidansının İngiltere ve ABD'de % 3-% 13 iken; Arjantin, Küba ve Çin'de sırasıyla % 60, % 38,6 ve % 1,9 olduğu bildirilmektedir (3) . Ayrıca PR beyaz ırkta (% 7,4) siyahlara (% 3,2) göre; Alaskalı (% 24,9) ve Asyalılarda (% 15,9), beyazlardan (% 6,3) ve siyahlardan (% 4,6) daha yüksek oranda görülmektedir (4)

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The effect of changing oxygen saturation protocols on the incidence of laser treatment for retinopathy of prematurity

Cited by 5 publications

References 26 publications

The pathophysiology of retinopathy of prematurity: an update of previous and recent knowledge

The pathophysiology of retinopathy of prematurity: an update of previous and recent knowledge

Effect of the oxygen saturation target on clinical characteristics of early- versus late-onset retinopathy of prematurity

Regression of Malignant Melanoma which Occured in the Basis of a Nevus: Case Report

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