The effect of central obesity on inflammation, hepcidin, and iron metabolism in young women

Stoffel, Nicole U.; El-Mallah, Carla; Herter-Aeberli, Isabelle; Bissani, Nour; Wehbe, Nour; Obeid, Omar; Zimmermann, Michael

doi:10.1038/s41366-020-0522-x

Cited by 72 publications

(85 citation statements)

References 43 publications

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“…In OW/OB, adipocytes produce multiple proinflammatory cytokines including 23) Higher BMI and greater central adiposity predict higher concentrations of CRP and IL-6. (7,24,25) In our study, baseline IL-6 (p<0.01), CRP and AGP (p<0.001 for both) were sharply higher in the OW/OB group compared to the NW group; thus, the choice of OW/OB as a model of chronic low-grade inflammation was appropriate. Ibuprofen is an NSAID commonly used for relief of inflammation; (26) it inhibits COX-1 and COX-2 derived pro-inflammatory prostanoids, which lowers circulating IL-6.…”

Section: Discussionmentioning

confidence: 48%

The effects of reducing chronic inflammation in overweight women on serum hepcidin and iron absorption with and without supplemental ascorbic acid

et al. 2020

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Although hepcidin synthesis is stimulated by inflammation and inhibited by iron deficiency, the strength of their opposing effects on serum hepcidin in humans remain unclear. It was recently shown that an inflammatory stimulus in anemic women did not increase serum hepcidin or decrease iron absorption. The enhancing effect of ascorbic acid on iron absorption may not be effective during inflammation, because of increased serum hepcidin. Our study aim was to test whether reducing inflammation in iron-depleted overweight women with low-grade inflammation would lower serum hepcidin and improve iron absorption with and without ascorbic acid, compared to normal-weight women without inflammation. Before and after 14d of anti-inflammatory treatment (3x600mg ibuprofen daily) in overweight and normal-weight women (n=36; age 19-46 y), we measured serum hepcidin and fractional iron absorption (erythrocyte iron incorporation) from 57Fe- and 58Fe-labeled test meals with and without ascorbic acid. There were significant group effects on interleukin (IL)-6, C-reactive protein, serum ferritin, and SHep (for all, p<0.05). There was a significant treatment effect on SHep (p<0.05): in overweight women, treatment decreased IL-6 by ≍30% and SHep by ≍45%. However, there were no significant treatment or group effects on FIA. Body iron stores were a significant positive predictor of SHep before and after treatment (p<0.001), but IL-6 was not. Reducing chronic inflammation in overweight women halved SHep but did not affect iron absorption with or without ascorbic acid, and the main predictor of iron absorption was body iron stores.

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Section: Discussionmentioning

confidence: 48%

The effects of reducing chronic inflammation in overweight women on serum hepcidin and iron absorption with and without supplemental ascorbic acid

et al. 2020

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“…NWCO or MUNW both had increased visceral adipose tissue, the accumulation of fat in liver and pancreas which were more prone to cause insulin resistance [23,24]. Besides, there were other mechanisms correlated with the central obesity inducing CVD in normal weight subjects, such as in ammation, impairments in iron homeostasis and oxidative stress [25,26].…”

Section: Discussionmentioning

confidence: 99%

Normal body weight with central obesity increases newly onset cardiovascular disease in adults from rural Northeast China

Yu¹,

Guo

et al. 2020

Preprint

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Background Cumulative evidence indicates that normal weight with central obesity (NWCO) is associated with cardiovascular diseases risk factors like hypertension, diabetes, dyslipidemia. However, the possible predictive effect of NWCO on newly onset cardiovascular diseases (CVD) including coronary heart disease (CHD) and stroke has not been studied in detail. Methods Participants underwent physical examination at 2012–2013 and followed-up at 2015–2017 who previously diagnosed CVD were excluded. Body mass index (BMI) ≥ 25 kg/m2 defined obesity, waist-to-height ratio ≥ 0.5 defined central obesity. Four groups: Normal weight without (NW) or NWCO, obesity without (OB) or with central obesity (OBCO). Results In total, 9439 participants (5006 men and 4433 women). The prevalence of different types of obesity were 39.6% for NW, 16.1% for NWCO, 4.1% for OB and 40.2% for OBCO. NWCO [HR = 1.565, 95%CI = 1.195, 2.051] and OBCO [HR = 1.845, 95%CI = 1.480, 2.300] were significantly associated with increasing risk of newly onset CVD. Besides, NWCO [HR = 2.337, 95%CI = 1.257, 4.344], OB [HR = 3.22, 95%CI = 1.166, 8.905] and OBCO [HR = 2.449, 95%CI = 1.386, 4.326] were all correlated with newly onset CHD but none of them had relationship with newly onset stroke. Conclusions We found that NWCO and OBCO were associated with newly onset CVD in rural Northeast Chinese adults. This underscored the effect of central obesity on CVD and suggested that even in individual with normal BMI, it is still necessary to prevent, monitor and control of central obesity.

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“…Thus, obesity-associated low-grade inflammation may induce low circulating serum iron and increases the risk of iron deficiency anemia through hepcidin-mediated reduced iron absorption and release from storage [ 29 ]. Irondeficiency disproportionally affects preschool-age children and women of reproductive age [ 5 , 30 ], but few studies have simultaneously examined inflammation and iron status of young obese women [ 31 ]. Evaluation of several iron status indices and inflammation markers in healthy obese compared with normal-weight women of similar age would provide insight in understanding iron status in the non-pregnant state.…”

Section: Introductionmentioning

confidence: 99%

“…Evaluation of several iron status indices and inflammation markers in healthy obese compared with normal-weight women of similar age would provide insight in understanding iron status in the non-pregnant state. Previously, Stoffel et al [ 31 ] evaluated different iron and inflammatory biomarkers in normal-weight vs. obese women. They found higher androidal fat mass (central adiposity) correlated with elevated C-reactive protein (CRP), α-1 glycoprotein (AGP), serum hepcidin, and total iron-binding capacity (TIBC), and lower serum iron/hepcidin ratio (SFe/Hep) and transferrin saturation (TSAT) [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

“…Previously, Stoffel et al [ 31 ] evaluated different iron and inflammatory biomarkers in normal-weight vs. obese women. They found higher androidal fat mass (central adiposity) correlated with elevated C-reactive protein (CRP), α-1 glycoprotein (AGP), serum hepcidin, and total iron-binding capacity (TIBC), and lower serum iron/hepcidin ratio (SFe/Hep) and transferrin saturation (TSAT) [ 31 ]. The present study examined the influence of obesity on inflammatory markers, iron status indicators, and serum lipids, in healthy women of childbearing age—obese vs. normal-weight.…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Markers and Hepcidin are Elevated but Serum Iron is Lower in Obese Women of Reproductive Age

Aguree

Reddy

2021

Nutrients

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Limited evidence suggests that serum iron and hepcidin concentrations are dysregulated in obesity and inflammation. The objective of the present study was to compare C-reactive protein, interleukin-6, circulating levels of hepcidin, serum lipids, and iron status in obese vs. normal-weight women of childbearing age. Healthy women aged 18–30 years were recruited for the study (n = 47: 25 obese and 22 normal weight). Fasting blood samples were obtained to measure serum lipids (total cholesterol, HDL, LDL cholesterol, triglycerides, non-HDL cholesterol), complete blood count, serum iron, total iron-binding capacity, transferrin saturation, serum ferritin, hepcidin, C-reactive protein, and interleukin-6. Obese women had significantly higher mean serum C-reactive protein (p < 0.001), interleukin-6 (p < 0.001), hepcidin (p = 0.024), triglycerides (p < 0.001) and total cholesterol/HDL ratio (p < 0.001) but lower HDL (p = 0.001) and serum iron/hepcidin ratio (p = 0.011) compared with normal-weight women. BMI correlated positively with inflammatory markers, triglycerides, LDL and total cholesterol/HDL ratio, and negatively with HDL and serum iron/hepcidin ratio. Serum iron correlated negatively with ferritin in the obese group (p = 0.030) but positively in normal weight women (p = 0.002). BMI and ferritin were the only predictors of serum iron/hepcidin ratio accounting for 23% of the variation among subjects. Studies are needed to examine anti-inflammatory dietary approaches that can improve iron biomarkers in obese women.

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The effect of central obesity on inflammation, hepcidin, and iron metabolism in young women

Cited by 72 publications

References 43 publications

The effects of reducing chronic inflammation in overweight women on serum hepcidin and iron absorption with and without supplemental ascorbic acid

The effects of reducing chronic inflammation in overweight women on serum hepcidin and iron absorption with and without supplemental ascorbic acid

Normal body weight with central obesity increases newly onset cardiovascular disease in adults from rural Northeast China

Inflammatory Markers and Hepcidin are Elevated but Serum Iron is Lower in Obese Women of Reproductive Age

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