The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism

Jakovljević, V.; Rašković, Aleksandar; Popović, M.; Sabo, John P.

doi:10.1007/bf03190450

Cited by 31 publications

(26 citation statements)

References 6 publications

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“…This action could be due to the reduction of the activity of the Na-K ATPase pump in the cortical collecting duct. However in mice, pre-treatment with parsley and celery extracts showed a decrease in the content of CYP450 in the liver compared to controls, and the mice exhibited a more pronounced response to phenobarbital [12]. …”

Section: Discussionmentioning

confidence: 99%

Internet Claims on Dietary and Herbal Supplements in Advanced Nephropathy: Truth or Myth

Vamenta-Morris¹,

Shoemaker-Moyle²,

Abdel‐Rahman³

2014

Am J Nephrol

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Background: The use of complementary/alternative medicine has garnered rising interest in recent years. Natural products including herbs, vitamins, and minerals are the most popularly consumed. The Internet is a ubiquitous source of information/market for these supplements. Aim: To systematically evaluate the dietary and herbal supplement recommended for patients with CKD and ESRD on the Internet, and try to distinguish between the claim of the manufacturer and proven scientific data. Methods: A questionnaire assessing each website was formulated. Each product ingredient was recorded in the questionnaire by two independent reviewers and statistically analyzed. Results: Of the 184 websites, 28% claimed to decrease CKD progression, 60% did not advise to consult a doctor before taking the supplement, and >90% did not mention any potential drug interaction, disease interaction, or caution in use during pregnancy or in children. The ten common plant ingredients claiming to be beneficial in kidney diseases were uva ursi, dandelion, parsley, corn silk, juniper, celery, buchu, horsetail, marshmallow, and stinging nettle. In contrast to their claims, these substances were not adequately studied in humans. The available animal studies showed detrimental effects and potential drug interactions with commonly used medications in the CKD/ESRD population. Conclusions: Nephrologists need to be cognizant of the lack of substantiated proven benefits of these substances and of the potential adverse effects in the animal models that can translate to the patients. Most importantly, the policy needs to change regarding the regulation of these products to prevent patient harm and misinformation. i 2014 S. Karger AG, Basel

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Section: Discussionmentioning

confidence: 99%

Internet Claims on Dietary and Herbal Supplements in Advanced Nephropathy: Truth or Myth

Vamenta-Morris¹,

Shoemaker-Moyle²,

Abdel‐Rahman³

2014

Am J Nephrol

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“…[98] The analgesic effect of celery is attributed to the involvement of celery in the cytochrome P450, which was found to be decreased in the liver homogenate. [99]…”

Section: Pharmacological Activitymentioning

confidence: 99%

An updated phytopharmacological review on medicinal plant of arab region: Apium graveolens Linn

Alasmari

Athar

Kadasah³

2017

Phcog Rev

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Apium graveolens Linn. (Karafs) is used in traditional medicine for the treatment of the various ailments. There is a need to explore and authenticate the pharmacological profile and medicinal importance of the Karafs. In this paper, the literature and the published work on Apium were collected using online resources “Google scholar”, “Web of science”, “Scopus” and “PubMed”. Each of the pharmacological activity was searched individually using the keywords “Apium/Karafs/Apium graveolens + individual pharmacological activity”. We documented the most cited and most recent literatures. The current findings illuminate the importance Karafs in the traditional medicine and their impact in treating various diseases. This review strongly supports the fact that the Apium has emerged as a good source of medicine in treating various diseases. There is also a need to isolate the bioactive phytochemicals present in this plant.

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“…In addition, patients on aspirin therapy should avoid ingesting Parsley due to possible increased sensitivity and allergic reactions [4,8]. The presence of myristicine, a narcotic which affects the central nervous system can interfere with opoid therapy and when ingested in excess may cause convulsions and serotonin syndrome [9,10]. …”

Section: Introductionmentioning

confidence: 99%

Biochemical and haematological assessment of toxic effects of the leaf ethanol extract of Petroselinum crispum (Mill) Nyman ex A.W. Hill (Parsley) in rats

Awe

Banjoko

2013

BMC Complement Altern Med

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BackgroundPetroselinum crispum, a bright green biennial shrub is widely used traditionally as a food additive and herbal remedies for many ailments. This study therefore aimed to assess the toxic effects of its leaf extract using some biochemical, haematological parameters.MethodsThe toxic effects were assessed by quantifying liver enzymes such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total serum protein and liver weight. Effects on haematological parameters were assessed by analysis of parked cell volume (PCV), red blood cell count (RBC), white blood cells (WBC) and haemoglobin (Hb) concentrations. Histopathological studies were done on the liver and kidneys.ResultsThe extract caused significant increase in serum activity of alanine amino transferase and blood urea nitrogen (BUN) levels at the dose of 1000 mg/kg. Other biochemical and haematological parameters were not affected at lower doses. Conversely, the liver weight was not affected after eight weeks of treatment at the dose levels studied. The organs obtained for pathological study, were structurally unchanged under histopathological evaluation at lower doses but inflammatory and necrotic features were observed at doses ≥ 1000 mg/kg.ConclusionThe results indicate that the leaf ethanol extract of Petroselinum crispum was hepatotoxic and nephrotoxic at continued oral doses equal to or more than 1000 mg/kg, but no obvious toxicity when used at lower doses. Therefore, there should be caution in its administration to avoid overdosing and known interaction with some medications. In addition, the plant should be kept away from pets and domestic animals and should not be cultivated on soil irrigated with waste water due to their ability to bio-accumulate toxic metals.

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The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism

Cited by 31 publications

References 6 publications

Internet Claims on Dietary and Herbal Supplements in Advanced Nephropathy: Truth or Myth

Internet Claims on Dietary and Herbal Supplements in Advanced Nephropathy: Truth or Myth

An updated phytopharmacological review on medicinal plant of arab region: Apium graveolens Linn

Biochemical and haematological assessment of toxic effects of the leaf ethanol extract of Petroselinum crispum (Mill) Nyman ex A.W. Hill (Parsley) in rats

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