The effect of cefoperazone sulbactam and piperacillin tazobactam on mortality in Gram-negative nosocomial infections

Güçlü, Ertuğrul; Kaya, Gülsüm; Öğütlü, Aziz; Karabay, Oğuz

doi:10.1080/1120009x.2020.1730087

Cited by 14 publications

(13 citation statements)

References 15 publications

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“…Many studies showed that tigecycline had positive in vitro antibacterial activity against resistant Acinetobacter baumannii, but sole use of it may lead to resistant bacteria [ 11 , 12 ]. Cefoperazone sulbactam sodium, the broad-spectrum antibiotic, has a certain therapeutic effect on respiratory tract infections, urogenital infections, intra-abdominal infections, bone and joint infections, intracranial infections, and skin and soft tissue infections caused by sensitive bacteria [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

The Investigation on Nosocomial Infection of Acinetobacter baumannii and the Clinical Analysis of Sequential Therapy of Cefoperazone/Sulbactam Sodium for Intracranial Infection

Xiong

Zeng

Shen

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. Intracranial infection is a serious complication after neurosurgery. According to a survey, the incidence of intracranial infection is about 2.2%-2.6%, and patients with severe symptoms may even pose a threat to their life safety. Objective. To explore the risk factors for intracranial infection caused by Acinetobacter baumannii after surgery and the clinical effect of sequential therapy of cefoperazone/sulbactam sodium. Methods. In this study, a retrospective study was used. In this case-control study, 48 cases of intracranial Acinetobacter baumannii infection after neurosurgery in our hospital from January 2016 to December 2021 were selected as the infection group, and 96 patients without intracranial infection after surgery during the same period were selected as the control group to study all kinds of related factors and analyze the risk factors for intracranial Acinetobacter baumannii infection; in addition, in accordance with the therapeutic regimen for anti-infection, the infection group was divided into the tigecycline group (patients with tigecycline therapy in this group) and the combined group (patients with tigecycline combined with cefoperazone/sulbactam sequential therapy), with 24 cases in each group in order to compare the therapeutic effects of the two groups. Results. Logistic regression factor model results show that increasing age of patients, surgical treatment for intracranial tumor or craniocerebral trauma, postoperative drainage time (≥3 days), and postoperative hospital stay (≥10 days) were the risk factors for postoperative intracranial infection of Acinetobacter baumannii in neurosurgical patients ( P < 0.05 ), and postoperative prophylactic antibiotic treatment can reduce the incidence of intracranial infection ( P < 0.05 ). The cerebrospinal fluid nucleated cell count, serum CRP, and serum PCT in the combined group 72 h after treatment were lower than those in the tigecycline group, and the difference was statistically significant ( P < 0.05 ). Compared with the clinical efficacy after 72-hour treatment, the cure rate and effective rate in the combined treatment group were 83.33% and 16.67%, respectively, and those in the tigecycline group were 54.17% and 33.33%, respectively. The invalid interest rate was 12.50%, and the combined treatment group was superior to the tigecycline group ( P < 0.05 ). Conclusion. For patients with craniocerebral surgery, targeted preventive interventions should be carried out for the risk factors that may lead to intracranial Acinetobacter baumannii infection. The clinical effect of tigecycline combined with cefoperazone and sulbactam sodium sequentially in the treatment of intracranial Acinetobacter baumannii infection is better.

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Section: Discussionmentioning

confidence: 99%

The Investigation on Nosocomial Infection of Acinetobacter baumannii and the Clinical Analysis of Sequential Therapy of Cefoperazone/Sulbactam Sodium for Intracranial Infection

Xiong

Zeng

Shen

et al. 2022

Computational and Mathematical Methods in Medicine

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“…β-lactam antibiotics can inhibit and kill normal intestinal flora, resulting in the reduction of VitK synthesis and the disorder of VitK-dependent coagulation factors (II, VII, IX and X), which results in coagulopathy. Coagulation dysfunction caused by cefoperazone/sulbactam sodium is the most common [8,9]. In a large retrospective study of 23,242 patients involved, prolonged PT and coagulopathy with cefoperazone/sulbactam were found in 5.3% and 9.2%, respectively, with thrombocytopenia in 15.7% and bleeding in 4.2% of patients [10].…”

Section: Discussionmentioning

confidence: 99%

Severe coagulopathy caused by cefminox sodium in a liver cirrhosis patient: a case report

Lin

et al. 2022

Infect Agents Cancer

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Cefminox sodium is an antimicrobial agent with broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Cefminox sodium has high security in clinical practice for its few adverse effects such as coagulation dysfunction, which is rare in clinical treatment. Even in patients suffering from chronic liver disease with coagulation dysfunction, it rarely leads to further deterioration of coagulation function. Therefore, patients with chronic liver disease develop severe coagulation dysfunction during the application of cefminox sodium, which is often mistaken for worsening of liver disease other than considered to be the side effect of the drug. Therefore, we report a 55-year-old female patient with liver cirrhosis and hepatocellular carcinoma treated with cefminox sodium intravenously twice for peritonitis. During the treatments, severe coagulopathy occurred, and the coagulation function quickly recovered after drug withdrawal. The diagnosis and treatment of this patient provides us with ideas for dealing with similar problems in clinical practice in the future.

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“…However, it is difficult to achieve ideal results with this drug alone. 8 and tetracycline. Qin Y et al 9 demonstrated that tigecycline can achieve a significant bactericidal effect in multidrug-resistant Acinetobacter baumannii.…”

Section: Discussionmentioning

confidence: 99%

Effects of Tigecycline combined with Cefoperazone on bacterial clearance and serum biochemical indexes in patients with pulmonary infections in ICU

Li¹,

Zhang

2022

Pak J Med Sci

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Objectives: To investigate the effects of tigecycline combined with Cefoperazone on bacterial clearance and the expression of serum biochemical indexes [C-reactive protein (CRP), leukocyte count (WBC) and procalcitonin (PCT)] in patients with infection in an intensive care unit (ICU). Methods: The clinical data of 79 patients with pulmonary infections within the ICU of Chenzhou first people’s Hospital from October 2019 to September 2021 were retrospectively analyzed. From the total, 38 patients received intravenous drip of Cefoperazone (control group), and 41 patients received intravenous drip of Cefoperazone and tigecycline (observation group). The treatment effect, bacterial clearance effect, serum biochemical index level and adverse reactions of the two groups were counted before and after treatment. Results: The total efficacy in the observation group (95.12%) was higher than that of the control group (78.95%) (P<0.05). After treatment, the bacterial clearance rate in the observation group (87.04%) was higher than that in the control group (66.67%) (P<0.05). After treatment, the levels of CRP, WBC and PCT in the two groups were lower than those before treatment (P<0.05), and the levels in the observation group were lower than those in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group (9.76%) and the control group (5.26%) (P>0.05). Conclusions: The combination of Cefoperazone and tigecycline in the treatment of ICU infection can effectively improve the treatment effect of the disease, have a significant bacterial clearance effect, and can reduce the serum levels of CRP, WBC and PCT. doi: https://doi.org/10.12669/pjms.38.6.5872 How to cite this:Li N, Zhang H. Effects of Tigecycline combined with Cefoperazone on bacterial clearance and serum biochemical indexes in patients with pulmonary infections in ICU. Pak J Med Sci. 2022;38(6):1622-1626. doi: https://doi.org/10.12669/pjms.38.6.5872 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The effect of cefoperazone sulbactam and piperacillin tazobactam on mortality in Gram-negative nosocomial infections

Cited by 14 publications

References 15 publications

The Investigation on Nosocomial Infection of Acinetobacter baumannii and the Clinical Analysis of Sequential Therapy of Cefoperazone/Sulbactam Sodium for Intracranial Infection

The Investigation on Nosocomial Infection of Acinetobacter baumannii and the Clinical Analysis of Sequential Therapy of Cefoperazone/Sulbactam Sodium for Intracranial Infection

Severe coagulopathy caused by cefminox sodium in a liver cirrhosis patient: a case report

Effects of Tigecycline combined with Cefoperazone on bacterial clearance and serum biochemical indexes in patients with pulmonary infections in ICU

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