The effect of carvacrol on muscarinic receptors of guinea‐pig tracheal chains

Boskabady, Mohammad Hossein; Jafari, Zahra; Pouraboli, Iran

doi:10.1002/ptr.3290

Cited by 43 publications

(34 citation statements)

References 10 publications

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“…Values of (CR-1) in the presence of extract from zataria and 10 nM atropine in two sets of experiments. inhibitory effect on muscarinic receptors (Boskabady, Jafari, & Pouraboli, 2011) similar to the results of the extract in this study was observed. These results suggest that the main constituent of the plant responsible for its inhibitory effect on muscarinic receptors is carvacrol.…”

Section: Natural Product Research 1525supporting

confidence: 94%

Anti-cholinergic effect ofZataria multifloraBoiss on guinea pig tracheal chains

Boskabady¹,

Jafari²,

Pouraboli³

et al. 2012

Natural Product Research

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The effects of three concentrations of aqueous-ethanolic extract, 10 nM atropine and saline on muscarinic receptors were tested on two groups of non-incubated (group 1; n = 7) and incubated tracheal chains with propranolol and chlorpheniramine (group 2; n = 6). The EC₅₀ of higher concentration of the extract (2 µg mL⁻¹) in group 2 was significantly greater than those of group 1 (p < 0.01). The maximum response obtained in the presence of all concentrations of extract in groups 1 and 2 were lower than saline (p < 0.05 to 0.001). There were parallel rightward shifts in the concentration response curves obtained for all concentrations of the extract in group 2. There was significant and positive correlation between the concentrations and the values of EC₅₀ in group 1 (p < 0.05) and group 2 (p < 0.001). These results indicate an anti-cholinergic effect of Zataria multiflora Boiss on the tracheal chains of guinea pigs. A β-adrenoceptor stimulatory effect for the plant was also suggested.

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Section: Natural Product Research 1525supporting

confidence: 94%

Anti-cholinergic effect ofZataria multifloraBoiss on guinea pig tracheal chains

Boskabady¹,

Jafari²,

Pouraboli³

et al. 2012

Natural Product Research

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“…The constituents of F. asafoetida include thymol (10%) (29), which did not show any relaxant effect on tracheal smooth muscle (1), ambelliprenin (less than 1%), which showed significantly lower relaxant effect compared to the plant extract (27) and carvacrol, which showed a potent relaxant effect on tracheal smooth muscle (30). The inhibitory effect of carvacrol on muscarinic receptors of tracheal smooth muscle was also observed previously (31). Therefore, carvacrol could contribute to the observed relaxant and inhibitory effect on muscarinic receptors of F. asafoetida gum extract.…”

Section: Discussionsupporting

confidence: 63%

The Inhibitory Effects of Ferula assafoetida on Muscarinic Receptors of Guinea-Pig Tracheal Smooth Muscle

Khazdair

Boskabady

Kiyanmehr

et al. 2015

Jundishapur J Nat Pharm Prod

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Background: In traditional medicine, asafoetida obtained from the roots of different Ferula assafoetida (F. asafoetida) is used for various therapeutic purposes such as whooping cough, pneumonia and bronchitis in children, as well as asthma. Objectives: In this study, the effect of asafoetida on muscarinic receptors of tracheal smooth muscle, as one possible mechanism responsible for the relaxant effect seen for the plant, was evaluated. Materials and Methods:The effects of three cumulative concentrations of aqueous extract of F. asafoetida (2.5, 5 and 10 mg/mL), 10 nM atropine, and saline on muscarinic receptors were tested in tracheal smooth muscle samples by performing cumulative concentration response curve to methacholine (a muscarinic receptor agonist) and assessing the shift in concentration response curves due to different concentrations of the extract and atropine. Results: The EC 50 obtained in the presence of higher concentration of the extract muscle was significantly higher compared to saline (P < 0.01). The maximum responses to methacholine in the presence of higher concentration of the extract (10 mg/mL) was significantly lower than that of saline (P < 0.05). The values of CR-1, obtained in the presence of all concentrations of the extract, were significantly lower compared to atropine in the experimental group (P < 0.01 to P < 0.001). Conclusions: These results showed an inhibitory effect for the extract of asafetida on muscarinic receptors of tracheal smooth muscle.

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“…Our previous study also showed relaxant effect of the other plant of this family ( Thymus vulgaris ) on tracheal smooth muscle [30]. The inhibitory effect of the extract of Z. multiflora and carvacrol on histamine (H1) [31] and muscarinic receptors [32–34] and its stimulatory effect on β -adrenoceptors [35] were demonstrated in our previous studies.…”

Section: Introductionmentioning

confidence: 79%

Effect of theZataria multifloraon Systemic Inflammation of Experimental Animals Model of COPD

Boskabady

Mhtaj

2014

BioMed Research International

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The effects of Zataria multiflora (Z. multiflora) on systemic inflammation in guinea pigs model of COPD were examined. Control animals, COPD (induced by exposing animals to cigarette smoke), COPD + drinking water containing three concentrations of the extract of Z. multiflora, and COPD + dexamethasone were studied (n = 6 for each group). Serum levels of IL-8 and malondialdehyde (MDA), total blood WBC (P < 0.01 for all cases), and eosinophil counts (P < 0.05) were higher and weight changes (P < 0.05) were lower in the COPD group compared to controls. IL-8 level (P < 0.001) and weight changes (P < 0.01 to P < 0.001) in all treated groups with Z. multiflora and total WBC number and MDA level in treated groups with two higher concentrations of the extract and lymphocytes percentage (P < 0.05) in the highest concentration of Z. multiflora and dexamethasone (P < 0.05 to P < 0.001) were significantly improved compared to the COPD group. Results showed a preventive effect of hydroethanolic extract from Z. multiflora on all measured parameters in animals model of COPD which was comparable or even higher (in the highest concentration) compared to the effect of dexamethasone at the concentration used.

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The effect of carvacrol on muscarinic receptors of guinea‐pig tracheal chains

Cited by 43 publications

References 10 publications

Anti-cholinergic effect ofZataria multifloraBoiss on guinea pig tracheal chains

Anti-cholinergic effect ofZataria multifloraBoiss on guinea pig tracheal chains

The Inhibitory Effects of Ferula assafoetida on Muscarinic Receptors of Guinea-Pig Tracheal Smooth Muscle

Effect of theZataria multifloraon Systemic Inflammation of Experimental Animals Model of COPD

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