The effect of cartilage-derived morphogenetic protein 2 on initial healing of a rotator cuff defect in a rat model

Murray, Douglas H.; Kubiak, Erik N.; Jazrawi, Laith M.; Araghi, Arash; Kummer, Frederick J.; Loebenberg, Mark I.; Zuckerman, Joseph D.

doi:10.1016/j.jse.2006.07.002

Cited by 59 publications

(42 citation statements)

References 14 publications

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“…In addition, several preliminary studies suggest adding exogenous growth factors to an injured tendon can enhance healing and repair [45,81,138,177]. For instance, the addition of cartilagederived morphogenic protein-2 to an animal tendon repair model recently reported an increase in the strength and organization of the repaired tendon [111,189].…”

Section: Growth Factorsmentioning

confidence: 99%

Treatment of Tendinopathy: What Works, What Does Not, and What is on the Horizon

Andres

Murrell

2008

Clinical Orthopaedics &Amp; Related Research

442

345

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Tendinopathy is a broad term encompassing painful conditions occurring in and around tendons in response to overuse. Recent basic science research suggests little or no inflammation is present in these conditions. Thus, traditional treatment modalities aimed at controlling inflammation such as corticosteroid injections and nonsteroidal antiinflammatory medications (NSAIDS) may not be the most effective options. We performed a systematic review of the literature to determine the best treatment options for tendinopathy. We evaluated the effectiveness of NSAIDS, corticosteroid injections, exercise-based physical therapy, physical therapy modalities, shock wave therapy, sclerotherapy, nitric oxide patches, surgery, growth factors, and stem cell treatment. NSAIDS and corticosteroids appear to provide pain relief in the short term, but their effectiveness in the long term has not been demonstrated. We identified inconsistent results with shock wave therapy and physical therapy modalities such as ultrasound, iontophoresis and low-level laser therapy. Current data support the use of eccentric strengthening protocols, sclerotherapy, and nitric oxide patches, but larger, multicenter trials are needed to confirm the early results with these treatments. Preliminary work with growth factors and stem cells is promising, but further study is required in these fields. Surgery remains the last option due to the morbidity and inconsistent outcomes. The ideal treatment for tendinopathy remains unclear.

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Section: Growth Factorsmentioning

confidence: 99%

Treatment of Tendinopathy: What Works, What Does Not, and What is on the Horizon

Andres

Murrell

2008

Clinical Orthopaedics &Amp; Related Research

442

345

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“…The effects of BMP-12 when added in a tendon healing model include the increase of tendon callus and the improvement of mechanical properties such as overall strength and stiffness, both after 1 week (Forslund et al, 2003;Majewski et al, 2008). However BMP-12 added during the first week of healing leads to a more organized tendon tissue (Murray et al, 2007), higher volumes of collagen I and an earlier shift of fibroblasts to fibrocytes (Majewski et al, 2008). Our results thus suggest a tightly controlled BMP-12 concentration, which possibly helps to coordinate the newly produced cells during proliferation in the early healing period.…”

Section: Bmp-12mentioning

confidence: 99%

Tendon Healing with Growth Factors

Müller¹,

Todorov²,

Heisterbach³

et al. 2012

Achilles Tendon

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“…Injection of recombinant adenovirus mediated-BMP-12 into a complete flexor digitorum profundus tendon laceration and repair model in chickens resulted in a two-fold increase in tensile strength and stiffness of the repaired tendons 4 weeks after surgery [44]. In a supraspinatus tendon defect model in rats, a recent study reported delivery of rhCDMP-2 (BMP-13) with a collagen sponge improved maximum loads to failure 4 and 6 weeks after surgery when compared to the untreated tendons [49]. At 6 weeks the CDMP-2-treated repairs were approximately 80% as strong as the failure strength for unoperated supraspinatus tendons.…”

Section: Literature Reviewmentioning

confidence: 99%

Biological Augmentation of Rotator Cuff Tendon Repair

Kovacevic

Rodeo

2008

Clinical Orthopaedics &Amp; Related Research

225

181

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A histologically normal insertion site does not regenerate following rotator cuff tendon-to-bone repair, which is likely due to abnormal or insufficient gene expression and/or cell differentiation at the repair site. Techniques to manipulate the biologic events following tendon repair may improve healing. We used a sheep infraspinatus repair model to evaluate the effect of osteoinductive growth factors and BMP-12 on tendon-to-bone healing. Magnetic resonance imaging and histology showed increased formation of new bone and fibrocartilage at the healing tendon attachment site in the treated animals, and biomechanical testing showed improved load-to-failure. Other techniques with potential to augment repair site biology include use of platelets isolated from autologous blood to deliver growth factors to a tendon repair site. Modalities that improve local vascularity, such as pulsed ultrasound, have the potential to augment rotator cuff healing. Important information about the biology of tendon healing can also be gained from studies of substances that inhibit healing, such as nicotine and antiinflammatory medications. Future approaches may include the use of stem cells and transcription factors to induce formation of the native tendon-bone insertion site after rotator cuff repair surgery.

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The effect of cartilage-derived morphogenetic protein 2 on initial healing of a rotator cuff defect in a rat model

Cited by 59 publications

References 14 publications

Treatment of Tendinopathy: What Works, What Does Not, and What is on the Horizon

Treatment of Tendinopathy: What Works, What Does Not, and What is on the Horizon

Tendon Healing with Growth Factors

Biological Augmentation of Rotator Cuff Tendon Repair

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