The Effect of Carboplatin Chemotherapy Regulation on Hearing Functions in Patients of Nasopharyngeal Carcinoma

Abstract

Introduction:
 The incidence of hearing loss after treatment with carboplatin-based chemotherapy in nasopharyngeal carcinoma (NPC) patients were evaluated, and relationships of loss with host factors, treatment-related factors were investigated.
 Objective:
 To evaluate the effect of giving a carboplatin chemotherapy regimen for 6 times chemotherapy (serial chemotherapy) on hearing function in patients with nasopharyngeal carcinoma. The incidence of hearing loss after treatment with carboplatin-based chemotherapy in nasopharyngeal carcinoma (NPC) patients were evaluated, and relationships of loss with host factors, treatment-related factors were investigated.
 Method:
 Thirty NPC patients were treated with carboplatin chemotherapy from 2015 to 2017 were analyzed. Pure tone audiometry and Distortion Product of Otoacoustic emission (DPOAE) were performed during the follow-up period, with a median time of 36 months, ranging from 24 to 36 months. Correlation of SNHL at frequencies (pure tone average, 0.5-8 kHz) with a series of factors was analyzed.
 Results:
 Among 30 participant (60 ears), using the Wilcoxon test, the mean threshold after series III was significant (p=0,000) and the mean of after series VI and significant (p= 0,000). The relationship between DPOAE results and pure tone audiometry was also carried out in the early stages of series III. Kaplan Meier's survival analysis improvement from post-III series (6 weeks) of participants who survived as many as 23 participants (76.67%) and in the post-chemotherapy evaluation of VI series (15 weeks) participants who survived as many as 8 participants. Bivariate statistical analysis using the Spearman non-parametric correlation test, there was a significant relationship between the mean dose and the decrease in the hearing threshold. p=0.00 (<0.01).
 Conclusion: 
 For NPC patients treated with carboplatin chemotherapy, There was an effect on the hearing function of the administration of carboplatin chemotherapy regimen for 6 series chemotherapy in patients with nasopharyngeal carcinoma.

Relationship between Primary Tumors of Nasopharyngeal Carcinoma with the Degree of Conductive Hearing Loss in Dr. Mohammad Hoesin Hospital Palembang

“…10,11,12 This study obtained results of audiometry the most patients with moderate conductive hearing loss as much as 20% and followed by mild conductive hearing loss of 13.3%. 13,14 This is following the literature that most NPC patients experience a conductive hearing loss with varying degrees according to the infiltration of tumor Conductive hearing loss is the most common NPC patient occurs in the ear on one side but the increase in the degree of tumor or late management can make the mass greater and can cause disturbances in both ears. Based on the bivariate analysis to see the relationship between the degree of NPC primary tumor and the incidence of conductive hearing loss there is a significant association in the left ear statistically (P = 0.007), while in the right ear there is no statistically significant association (P = 0.207).…”