The effect of carbon nanoparticles on biological properties of polyester nanocomposites

Abstract

The aim of present study was to determine the hemocompatibility, cellular response of endothelial cells and bacterial adhesion to a new polyester nanocomposite. The carbon nanoparticle nanocomposite was prepared via in situ polymerization of monomers to obtain material of hardness 55 Sh D similar to polyurethanes used in medical applications, for example, in heart-assisting devices. The carbon nanoparticle-containing polyester exhibits markedly reduced bacterial colonization, as compared to commercially available polyurethanes. Further the nanocomposite possesses markedly improved hemocompatibility, as determined by flow cytometry, and robust endothelialization. Possible explanations for these beneficial properties include surface nanoroughness of carbon nanoparticle-containing nanocomposites and presence of fatty acid sequences within polymer structure.

The effects of nano-sized carbon fillers on the physico-chemical, mechanical, and biological properties of polyester nanocomposites

“…PET-DLA multiblock thermoplastic elastomers containing 40 wt% (PET-DLA 40) and 60 wt% (PET-DLA 60) of hard segments (W h ) of poly(ethylene terephthalate) (PET) and soft segments comprising amorphous fatty acid ester sequences based on dilinoleic acid (DLA), as well as nanocomposites containing 0.05, 0.1, 0.25, 0.5, 1 wt% of graphene (Graphene Supermarket, Grade A0-3, USA), 0.05, 0.1, 0.25, 0.5, 1 wt% of carbon black (CB) (Cabot, ELFTEX TP, USA) and 0.05, 0.1, 0.25, 0.5 wt% of MWCNT (CNT) (Nanocyl 7000, Belgium) were synthesized via in situ two-stage polymerization, based on previous work [18,19]. For all nanocomposites containing 0.05 wt% to 0.25 wt% of nanofiller, dispersions were prepared only in ethylene glycol.…”

Biological Effects, Applications and Design Strategies of Medical Polyurethanes Modified by Nanomaterials

“…45 However, PU exhibits hydrolytic degradation and thrombogenicity when in contact with blood components, such as platelets and cholesterol esterase. [46][47][48] Surface endothelialization by endothelial cells to block coagulation cascade reactions and prevent platelet activation and aggregation is the key to preventing thrombogenesis and improving the hemocompatibility of implant materials in the cardiovascular system. 45 The addition of graphene oxide (GO), carbon NPs, and Fe-NPs to PUs yields rough, hydrophilic surfaces that promote endothelial cell adhesion and proliferation.…”

“… Antibacterial coating [ 92 ] Ag/TiO 2 NPs PU acrylate nanocomposites 6 (Ag), 30 (TiO 2 ) 5 wt% or 10 wt% Dip coating Increases antimicrobial activity against Escherichia coli Antibacterial activity [ 93 ] Au-NPs and Fe-NPs TPU 3.3 ± 0.4 (Au); 8.0 ± 0.1 (Fe) NA Laser ablation Enhances protein adsorption to facilitate cell adhesion and growth. Wound healing [ 50 ] Carbon dot Water dispersible hyperbranched PU 3.2 1 wt% Emulsion mixing Promotes osteogenic differentiation and angiogenesis Bone tissue regeneration [ 24 ] Carbon NPs Poly(aliphatic/aromatic-ester)s 30 0.2 wt% In-situ polymerization Reduces bacterial colonization and improves hemocompatibility Cardiovascular system [ 46 ] CS/temozolomide NPs Poly (ε-caprolactone diol) based PU 75 NA Emulsion mixing Sustained TMZ release for 30 days Drug delivery [ 65 ] Fe 2 O 3 -NPs Poly (ε-caprolactone) based PU 60–90 0.1 wt% Emulsion mixing Increases cell attachment, supports cell signaling for target tissue regeneration Nerve repair ...…”

Double-Emulsion Copolyester Microcapsules for Sustained Intraperitoneal Release of Carboplatin

“…Poly(ethylene terephthalate-ethylene dilinoleate) (PET-DLA) was synthesized via a two-stage process of transesterification and polycondensation from the melt as described previously [40,41]. Briefly, the transesterification was carried out in the presence of monoethylene glycol, and dimethyl terephthalate at 180 • C, until 95% of methanol was collected.…”