The Effect of Carbon Monoxide’s Donor Corm-2 on Erythrocyte Aquaporins

Beschasnyi, S. P.; Hasiuk, O.

doi:10.26724/2079-8334-2021-2-76-167-173

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…After the entry of such compounds into cells, a slow release of CO occurs due to ligand exchange reactions, and that pace of CO release minimizes toxic effects [268]. CORM compounds have recently been widely used in vivo in studies on animals or model cell systems [269,270]. The effect of such CO donors on plants has not been properly studied yet.…”

Section: Carbon Monoxide Donorsmentioning

confidence: 99%

Gasotransmitters in Plants: Mechanisms of Participation in Adaptive Responses

Kolupaev¹,

Karpets²,

Shkliarevskyi³

et al. 2022

TOASJ

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Plant adaptive responses to environmental stresses occur with the participation of plant hormones and a network of signaling mediators. Among these, a growing attention has been paid over the recent years to gasotransmitters (GT). This term is used to define small gaseous molecules synthesized by living organisms that perform signaling functions. The main GT in plants are nitrogen monoxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). The mechanisms of GT participation in the processes of plant adaptation to unfavorable environmental conditions have not yet been studied enough, which limits the use of GT in crop production. This review summarizes the latest data on GT synthesis in plants, the ability of GT to induce post-translational protein modifications in plants and to functionally interact with each other and with other signaling mediators. Particular attention is paid to the participation of GT in the regulation of antioxidant system, the state of cytoskeleton, and stomatal reactions of plants. These effects are important for stimulation by gasotransmitters the adaptation of plants to extreme temperatures, drought, and salinity. The possibilities of using GT donors in crop production were also considered.

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Section: Carbon Monoxide Donorsmentioning

confidence: 99%

Gasotransmitters in Plants: Mechanisms of Participation in Adaptive Responses

Kolupaev¹,

Karpets²,

Shkliarevskyi³

et al. 2022

TOASJ

View full text Add to dashboard Cite

show abstract

Gasotransmitter Carbon Monoxide: Synthesis and Functions in Plants

Kolupaev

2022

Russ J Plant Physiol

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The Carbon Monoxide Donor, Topiramate, and Blockers of Aquaporine Receptors Decrease Myocardial Ischemia-Reperfusion Injiry

Beschasnyi¹,

Hasiuk²

2021

Fiziol Zh

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We investigated the metabolism of mouse isolated heart under the influence of tricarbonyldichlorothenium (II)- dimer (CORM-2 and 2,3-4,5-bis-O-isopropylidene-βD-fructopyranose sulfamate (topiramate) as potential blockers of aquaporine channel (AQP3) of cardiac myocytes. The results were compared with those obtained from the group receiving anti-AQP3 monoclonal antibodies. A decrease in coronary flow was found during the period preceding ischemia (topiramate did not cause this effect). However, at the end of reperfusion, CORM-2 was responsible for its stabilization. This compound did not affect glucose intake (topiramate increased it only at the end of reperfusion), decreased Ca2+ deposition in cardiac muscle (AQP3-IgG antibodies and topiramate had similar effect), decreased creatinine release, AST (especially at the end of reperfusion). The action of CORM-2 increased the amplitude of the R waveform before ischemia and during reperfusion. At the end of reperfusion the R-wave amplitude decreased. The effect of topiramate caused an increase in amplitude only at the beginning of reperfusion. Administration of CORM-2, topiramate and antibodies resulted in prolongation of the interval before and during ischemia. At the same time, the effect of these drugs and antibodies reduced the development of ischemic damage. The results indicate that the released CO from CORM-2 has effects similar to those of anti-AQP3 antibodies. The action of topiramate had signs of calcium channel blocking.

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The Effect of Carbon Monoxide’s Donor Corm-2 on Erythrocyte Aquaporins

Cited by 3 publications

References 12 publications

Gasotransmitters in Plants: Mechanisms of Participation in Adaptive Responses

Gasotransmitters in Plants: Mechanisms of Participation in Adaptive Responses

Gasotransmitter Carbon Monoxide: Synthesis and Functions in Plants

The Carbon Monoxide Donor, Topiramate, and Blockers of Aquaporine Receptors Decrease Myocardial Ischemia-Reperfusion Injiry

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