The Effect of Carbamazepine on Endocrine and Sleep EEG Variables in a Patient with 48-Hour Rapid Cycling, and Healthy Controls

Riemann, Dieter; Gann, Horst; Hohagen, Fritz; Bahro, Marcel; Müller, Wernér E.G.; Bergef, Mathias

doi:10.1159/000118974

Cited by 29 publications

(14 citation statements)

References 25 publications

(30 reference statements)

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“…Riemann/Voderholzer/Berger Our own work in a rapid cycling patient with day-today changes from hypomanic to depressed mood revealed that sleep following a manic day showed the same abnormalities of REM sleep as the sleep following a depressed day [Riemann et al, 1993a;Gann et al, 1993].…”

Section: Sleep In Maniamentioning

confidence: 99%

Sleep and Sleep-Wake Manipulations in Bipolar Depression

Riemann

Voderholzer

Berger³

2002

Neuropsychobiology

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In the last 30 years, it has been convincingly demonstrated that sleep in major depression is characterized by disturbances of sleep continuity, a reduction of slow wave sleep, a disinhibition of REM sleep including a shortening of REM latency (i.e. the time between sleep onset and the occurrence of the first REM period) and an increase in REM density. Furthermore, manipulations of the sleep-wake cycle like total or partial sleep deprivation or phase advance of the sleep period have been proven to be effective therapeutic strategies for patients with unipolar depression. The database concerning sleep and sleep-wake manipulations in bipolar disorder in comparison is not yet as extensive. Studies investigating sleep in bipolar depression suggest that during the depressed phase sleep shows the same stigmata as in unipolar depression. During the hypomanic or manic phase, sleep is even more curtailed, though subjectively not experienced as disturbing by the patients. REM sleep disinhibition is present as well. An important issue is the question, whether sleep-wake manipulations can also be applied in patients with bipolar depression. Work by others and our own studies indicate that sleep deprivation and a phase advance of the sleep period can be used to treat bipolar patients during the depressed phase. The risk of a switch into hypomania or mania does not seem to be more pronounced than the risk with typical pharmacological antidepressant treatment. For patients with mania, sleep deprivation is not an adequate treatment – in contrast, treatment strategies aiming at stabilizing a regular sleep-wake schedule are indicated.

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Section: Sleep In Maniamentioning

confidence: 99%

Sleep and Sleep-Wake Manipulations in Bipolar Depression

Riemann

Voderholzer

Berger³

2002

Neuropsychobiology

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“…These data are strikingly close to our data in BPD patients. In the studies by Riemann et al [73] and Gann et al [74], CBZ did not modify REM latency and REM percentage in healthy people. This was also the case in our BPD patients.…”

Section: Discussionmentioning

confidence: 79%

“…Regarding the sleep EEG parameters, CBZ has been shown to increase SWS [72][73][74] from 6.8 B 5.3 to 13.2 B 7% in healthy subjects. These data are strikingly close to our data in BPD patients.…”

Section: Discussionmentioning

confidence: 96%

“…Yang et al [72] described a reduction in REM sleep. CBZ has also been found to improve sleep continuity parameters in healthy subjects [73,74]. In epilepsy, CBZ has been shown to reduce REM sleep and increase REM fragmentation [75,76].…”

Section: Introductionmentioning

confidence: 99%

“…It has also been reported to increase adrenocorticotropin (ACTH) response to the hypothalamic corticotrophin-releasing factor (CRF) [70,71]. Regarding sleep EEG in healthy subjects, CBZ has been shown to increase slow wave sleep (SWS) [72][73][74] and not to modify REM latency and REM duration [74]. Yang et al [72] described a reduction in REM sleep.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Carbamazepine on Dexamethasone Suppression and Sleep Electroencephalography in Borderline Personality Disorder

Fuente

Bobes²,

Vizuete³

et al. 2002

Neuropsychobiology

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The pathophysiology of borderline personality disorder (BPD) remains obscure, but there is mounting evidence of brain dysfunction without focal abnormality. The dexamethasone suppression test (DST) and sleep electroencephalography (sleep EEG) have been studied in BPD, but the findings seem to be related to a concomitant axis I diagnosis of major depression (MD) rather than to BPD itself. There is no effective treatment for BPD. Carbamazepine (CBZ) has shown contradictory results and in a previous study, our results were negative. In this study, we investigated the effects of CBZ versus placebo on the DST and sleep EEG in a sample of 20 BPD patients without concomitant MD. CBZ given at doses that are therapeutic for epilepsy and affective disorders may have an effect on the DST and sleep EEG in BPD. CBZ significantly increased the postdexamethasone plasma cortisol values. This did not parallel MD or an increase in the Hamilton depression rating scores. CBZ also increased slow wave sleep (SWS). The mechanisms by which CBZ increased postdexamethasone plasma cortisol levels and SWS in BPD are discussed.

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Sleep and Epilepsy

Chokroverty

Nobili²

2017

Sleep Disorders Medicine

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The Effect of Carbamazepine on Endocrine and Sleep EEG Variables in a Patient with 48-Hour Rapid Cycling, and Healthy Controls

Cited by 29 publications

References 25 publications

Sleep and Sleep-Wake Manipulations in Bipolar Depression

Sleep and Sleep-Wake Manipulations in Bipolar Depression

Effects of Carbamazepine on Dexamethasone Suppression and Sleep Electroencephalography in Borderline Personality Disorder

Sleep and Epilepsy

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