The Effect of Cannabis Plant Extracts on Head and Neck Squamous Cell Carcinoma and the Quest for Cannabis-Based Personalized Therapy

Blal, Kifah; Besser, Elazar; Procaccia, Shiri; Schwob, Ouri; Lerenthal, Yaniv; Abu-Tair, Jawad; Meiri, David; Benny, Ofra

doi:10.3390/cancers15020497

Cited by 7 publications

(14 citation statements)

References 61 publications

(82 reference statements)

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“…Recent studies attempt to unveil the link between the pathogenesis of oral cancer and cannabinoids, investigating their potential as risk factors or their value as prognostic biomarkers, but also as therapeutic targets in the management of cancers [62,63].…”

Section: Endogenous and Exogenous Cannabinoids And Their Mechanisms O...mentioning

confidence: 99%

Role of Cannabinoids in Oral Cancer

Cretu,

Zamfir,

Bucurica

et al. 2024

IJMS

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Cannabinoids have incited scientific interest in different conditions, including malignancy, due to increased exposure to cannabis. Furthermore, cannabinoids are increasingly used to alleviate cancer-related symptoms. This review paper aims to clarify the recent findings on the relationship between cannabinoids and oral cancer, focusing on the molecular mechanisms that could link cannabinoids with oral cancer pathogenesis. In addition, we provide an overview of the current and future perspectives on the management of oral cancer patients using cannabinoid compounds. Epidemiological data on cannabis use and oral cancer development are conflicting. However, in vitro studies assessing the effects of cannabinoids on oral cancer cells have unveiled promising anti-cancer features, including apoptosis and inhibition of cell proliferation. Downregulation of various signaling pathways with anti-cancer effects has been identified in experimental models of oral cancer cells exposed to cannabinoids. Furthermore, in some countries, several synthetic or phytocannabinoids have been approved as medical adjuvants for the management of cancer patients undergoing chemoradiotherapy. Cannabinoids may improve overall well-being by relieving anxiety, depression, pain, and nausea. In conclusion, the link between cannabinoid compounds and oral cancer is complex, and further research is necessary to elucidate the potential risks or their protective impact on oral cancer.

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Section: Endogenous and Exogenous Cannabinoids And Their Mechanisms O...mentioning

confidence: 99%

Role of Cannabinoids in Oral Cancer

Cretu,

Zamfir,

Bucurica

et al. 2024

IJMS

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“…Cell death via proapoptotic and anti-proliferative activity of 24 cannabis extracts on head and neck squamous cell carcinoma, had an effect proportional to the CBD content. Extract with the highest CBD content possessed the highest cytotoxic effect, while extracts with minimal CBD had a neglectable cytotoxic effect ( Blal et al, 2023 ).…”

Section: Cannabinoids As Anti-cancer Drugsmentioning

confidence: 99%

Should oncologists trust cannabinoids?

et al. 2023

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Cannabis enjoyed a “golden age” as a medicinal product in the late 19th, early 20th century, but the increased risk of overdose and abuse led to its criminalization. However, the 21st century have witnessed a resurgence of interest and a large body of literature regarding the benefits of cannabinoids have emerged. As legalization and decriminalization have spread around the world, cancer patients are increasingly interested in the potential utility of cannabinoids. Although eager to discuss cannabis use with their oncologist, patients often find them to be reluctant, mainly because clinicians are still not convinced by the existing evidence-based data to guide their treatment plans. Physicians should prescribe cannabis only if a careful explanation can be provided and follow up response evaluation ensured, making it mandatory for them to be up to date with the positive and also negative aspects of the cannabis in the case of cancer patients. Consequently, this article aims to bring some clarifications to clinicians regarding the sometimes-confusing various nomenclature under which this plant is mentioned, current legislation and the existing evidence (both preclinical and clinical) for the utility of cannabinoids in cancer patients, for either palliation of the associated symptoms or even the potential antitumor effects that cannabinoids may have.

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“…Cells were assessed via WST-1 proliferation assay. The cannabis extract had a significant antiproliferative effect on Scc25 at 4–6 µg/mL when applied for 72 h. At 8 µg/mL, the extract was already effective after 24 h. It was suggested to use decarboxylated CBD-type extracts enriched with CBC for future preclinical trials aimed at HNSCC treatment [ 39 ].…”

Section: Antitumor Properties Of Cannabinoidsmentioning

confidence: 99%

Cannabinoids in Treating Chemotherapy-Induced Nausea and Vomiting, Cancer-Associated Pain, and Tumor Growth

Bathula,

Maciver

2023

IJMS

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Cannabis has been used as an herbal remedy for thousands of years, and recent research indicates promising new uses in medicine. So far, some studies have shown cannabinoids to be safe in helping mitigate some cancer-associated complications, including chemotherapy-induced nausea and vomiting, cancer-associated pain, and tumor growth. Researchers have been particularly interested in the potential uses of cannabinoids in treating cancer due to their ability to regulate cancer-related cell cycle pathways, prompting many beneficial effects, such as tumor growth prevention, cell cycle obstruction, and cell death. Cannabinoids have been found to affect tumors of the brain, prostate, colon and rectum, breast, uterus, cervix, thyroid, skin, pancreas, and lymph. However, the full potential of cannabinoids is yet to be understood. This review discusses current knowledge on the promising applications of cannabinoids in treating three different side effects of cancer—chemotherapy-induced nausea and vomiting, cancer-associated pain, and tumor development. The findings suggest that cannabinoids can be used to address some side effects of cancer and to limit the growth of tumors, though a lack of supporting clinical trials presents a challenge for use on actual patients. An additional challenge will be examining whether any of the over one hundred naturally occurring cannabinoids or dozens of synthetic compounds also exhibit useful clinical properties. Currently, clinical trials are underway; however, no regulatory agencies have approved cannabinoid use for any cancer symptoms beyond antinausea.

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The Effect of Cannabis Plant Extracts on Head and Neck Squamous Cell Carcinoma and the Quest for Cannabis-Based Personalized Therapy

Cited by 7 publications

References 61 publications

Role of Cannabinoids in Oral Cancer

Role of Cannabinoids in Oral Cancer

Should oncologists trust cannabinoids?

Cannabinoids in Treating Chemotherapy-Induced Nausea and Vomiting, Cancer-Associated Pain, and Tumor Growth

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