The effect of candesartan on blood pressure, metabolic profile and renal function in hypertensive patients

Bădilă, Elisabeta; Frunza, S.; Tîrziu, Cristina; Bartos, D.; Dorobanţu, Maria

doi:10.1016/j.ijcard.2009.09.457

Cited by 2 publications

(1 citation statement)

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“…Rosuvastatin (RS) inhibits the HMG-CoA reductase enzyme, which promotes the production of cholesterol in the liver [11]. The positive impact of these three drugs on the metabolic effect was inspired by previously published studies in the literature [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

A Robust and Reliable UPLC Method for the Simultaneous Quantification of Rosuvastatin Calcium, Glibenclamide, and Candesartan Cilexetil

Ibrahim,

Sherif,

Alshora

et al. 2024

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Metabolic syndrome is an associated condition that occurs together and increases the risk of heart disease and diabetes. These conditions include high blood pressure, high blood sugar, and high body mass index (BMI) in terms of cholesterol and triglyceride levels. Most of the elderly population may administer three drugs to control the above conditions. Therefore, this study aims to develop an analytical assay for the precise analysis of three components and to formulate a Self-Nanoemulsifying Drug-Delivery System (SNEDDS) loaded with three drugs: Rosuvastatin Calcium (RC; antilipidemic), Glibenclamide (GB; antidiabetic), and Candesartan Cilexetil (CC; antihypertensive). A design of the experiment was developed at a level of 32, and the influence of column temperature and flow rate was studied in terms of retention time, peak area, peak asymmetry, and resolution. The assay was subjected to several studies to ensure its validation. Under the optimized conditions—column temperature at 50 °C and flow rate at 0.25 mL/min—the three drugs, RC, GB, and CC, are separated. Their retention times are 0.840, 1.800, and 5.803 min, respectively. The assay was valid in terms of linearity, accuracy, and precision. Moreover, the developed assay shows a good tolerance against any change in the condition. The assay was tested also to separate the drugs in a pharmaceutical formulation as SNEDDs. The assay successfully separates the drug with a good resolution.

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