The effect of cancer treatment on female fertility and strategies for preserving fertility

Maltaris, Theodoros; Seufert, R.; Fischl, Franz; Schaffrath, Michael; Pollow, K.; Koelbl, Heinz; Dittrich, Ralf

doi:10.1016/j.ejogrb.2006.08.006

Cited by 171 publications

(165 citation statements)

References 49 publications

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“…Six studies were prospectively randomized (Cobleigh et al, 1995;Laml et al, 2000;Dada et al, 2001;Walshe et al, 2006;Maltaris et al, 2007;Megan et al, 2009) and six were case series with control (Bonadonna et al, 1985;Kreuser et al, 1990;Ortin et al, 1990;Ataya et al, 1993;Shalev et al, 2003;Lamar et al, 2009). The randomized controlled studies included 340 patients (173 in the study group and 167 in the control group).…”

Section: Resultsmentioning

confidence: 99%

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Gonadotrophin Releasing Hormone Analogues for Ovarian Function Preservation in Young Females Undergoing Chemotherapy

Bansal

Patel²,

Rai³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Chemotherapy has significantly improved the prognosis of cancer patients with various malignancies. However, female patients, especially those whoich are premenopausal, suffer from significant chemotherapy induced ovarian function impairment, which decreases their quality of life. Many new techniques for ovarian preservation have been established in recent years. Although the use of gonadotrophin releasing hormone analogues (GnRHa) for this purpose is not a new concept, its effectiveness in protection of ovarian function is still debatable. This article deals with studies and metaanalyses which have been undertaken in the past, demonstrating the impact of GnRHa in ovarian function preservation, and whether their use can be implemented in routine practice.

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Section: Resultsmentioning

confidence: 99%

“…Over the last 30 years, the 5-year survival rate for children with cancer has improved from 58% to approximately 80%; and for adults from 50% to almost 70% (Maltaris et al, 2007). As a result, the treatment related side effects and quality of life are now being increasingly recognized and addressed.…”

Section: Introductionmentioning

confidence: 99%

Gonadotrophin Releasing Hormone Analogues for Ovarian Function Preservation in Young Females Undergoing Chemotherapy

Bansal

Patel²,

Rai³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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show abstract

“…These observations could open novel medical options in order to sustain the fertility of women undergoing cancer therapy. It is well known that chemotherapy and radiation therapy for treating cancer leads to depletion of the ovarian oocyte reserve and leads to premature ovarian failure (POF) and hence premature menopause (Maltaris et al, 2007). Therefore, possible treatments that are based on the inhibition of the TAp63 pathway could allow the preservation of the oocyte pool following cancer therapy.…”

Section: Frontiers In Genetics | Cancer Geneticsmentioning

confidence: 99%

The DNA Damage Response in Mammalian Oocytes.

Marangos

2012

Biology of Reproduction

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“…16 The total dose of radiation to the pelvis needed to increase the risk of premature ovarian failure is in the order of 20Gy. 17,18 Of the 50Gy delivered to the breast during standard wholebreast radiotherapy, only 2.1-7.6Gy reaches the pelvis via internal scatter, which is an order of magnitude less than the dose needed to induce premature ovarian failure. and/or an ultrasound-guided antral follicle count.…”

Section: Young Women With Cancermentioning

confidence: 99%

Fertility Preservation Options for Patients with Cancer

Hulvat¹,

Jeruss²

2010

European Oncology &Amp; Haematology

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Improving survival for many cancers that affect children and young adults, together with advances in fertility preservation, make a cancer-free future that includes a family a realistic possibility for patients who desire this option. Although it is difficult for many clinicians and patients to reconcile fears surrounding a life-threatening diagnosis with hope for long-term survival and even a future family, addressing this vital survivorship issue early in the course of diagnosis and treatment is imperative if the fullest range of fertility-preserving options is to be offered.Oncological therapies, including chemotherapy, radiation and surgery, pose various threats to fertility. Children, adolescents and young men and women with cancer have different options for maintaining their ability to have biological children. The current state of the science for fertility preservation in each of these demographic groups is discussed in this article. A multidisciplinary approach to the care of young cancer patients, a timely assessment of threats to fertility and opportunities for intervention provide young cancer patients with the best chance for a healthy future that includes biological offspring. KeywordsFertility preservation, oncofertility, cancer, chemotherapy, embryo cyropreservation A discussion of a patient's desires for future fertility is a challenging topic to raise in the early stages of a cancer diagnosis. It is difficult for many clinicians and patients to reconcile fears surrounding a life-threatening diagnosis with hope for long-term survival and even a future family. Yet improved survival rates for many cancers that affect young patients and recent advances in fertility preservation, taken together, make planning for a cancer-free life that includes a family a reality. Both men and women have similar threats to fertility inherent to treatment for cancer, but the opportunities to intervene are quite different. The following is a review of the current state of the science of fertility preservation for cancer patients. Men with CancerFertility challenges in men with cancer are the most straightforward because of the relative ease of obtaining and cryopreserving sperm. This is not to say that significant threats to fertility do not exist.Treatments for cancer can cause direct damage to the germinal epithelium of the testis, disrupt the hypothalamic-pituitary-gonadal axis and cause psychological depression, which also affects fertility. High-dose pelvic irradiation used to treat these malignancies, as well as rectal malignancies, may also permanently damage testicular and erectile function.2 Radiation not directed towards the pelvis can also be toxic to sperm due to internal scatter, even at low doses. 3,4 Spermatogenesis is a process that is extremely vulnerable to the damaging effects of cytotoxic chemotherapy, and azoospermia or oligospermia frequently result. 5-7Cryopreservation of human sperm is an accepted technology in common use and there are reports of viable fertilisation with sperm store...

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The effect of cancer treatment on female fertility and strategies for preserving fertility

Cited by 171 publications

References 49 publications

Gonadotrophin Releasing Hormone Analogues for Ovarian Function Preservation in Young Females Undergoing Chemotherapy

Gonadotrophin Releasing Hormone Analogues for Ovarian Function Preservation in Young Females Undergoing Chemotherapy

The DNA Damage Response in Mammalian Oocytes.

Fertility Preservation Options for Patients with Cancer

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