The Effect of Calcium Ions on Electrical Properties of Striated Muscle Fibres

Ishiko, Nobusada; Satō, Masayasu

doi:10.2170/jjphysiol.7.51

Cited by 67 publications

(43 citation statements)

References 5 publications

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“…In high-Ca solution the resting potential was consistently larger, a result which agrees with other reports (del Castillo & Stark, 1952;Jenerick & Gerard, 1953;Jenerick, 1959;Gossweiler et al 1954;Ishiko & Sato, 1957). Although the muscle membrane resistance is also increased by increasing the external concentration of calcium (Tamashige, 1951;Jenerick, 1959) Fig.…”

supporting

confidence: 90%

Effects of calcium on the conductance change of the end‐plate membrane during the action of transmitter

Takeuchi¹

1963

The Journal of Physiology

176

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supporting

confidence: 90%

Effects of calcium on the conductance change of the end‐plate membrane during the action of transmitter

Takeuchi¹

1963

The Journal of Physiology

176

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“…Koketsu & Noda, 1962), whether or not calcium was present. DISCUSSION Further confirmation has been obtained of the observation that calcium deprivation can lead to a drastic fall of membrane potential in frog skeletal muscle (Bulbring et al 1956;Ishiko & Sato, 1957;Edman & Grieve, 1961). This occurs somewhat more rapidly when EDTA is present.…”

Section: Resultsmentioning

confidence: 56%

“…Frank (1958), using a paraffin-gap recording technique, reported that the depolarization produced by potassium chloride, and by implication the resting potential, was not affected by calcium depletion in the toe muscle of the frog. It is possible that the toe muscle is different in this respect to the frog sartorius muscle, in which the fall is now well documented (Bulbring et al 1956;Ishiko & Sato, 1957;Edman & Grieve, 1961;Koketsu & Noda, 1962); however, Curtis (1963) has also described a fall of resting potential in the toe muscle, using intracellular microelectrodes.…”

Section: Resultsmentioning

confidence: 99%

The role of resting potential changes in the contractile failure of frog sartorius muscles during calcium deprivation

Jenden¹,

Reger²

1963

The Journal of Physiology

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“…With higher concentrations (10-15 mM) the height was reduced to about 2 with a half-time of 5-10 sec, and regained its normal value in 1-8 mM-Ca at the same rate. An increase of [Ca]o from 1-8 to 15 mm does not very much change the time course of the action potential (Ishiko & Sato, 1957), but it increases the threshold of excitation. Therefore, the possibility that the reduction of contraction is partly due to a block of conduction in certain regions of the fibre could not be completely excluded.…”

Section: Resultsmentioning

confidence: 88%

“…The effect of Ca on the sodium-carrying system and on the system which controls contraction The system that controls sodium conductance in excitable membranes and the effect of Ca on it has been extensively investigated during recent years (squid giant axon, Hodgkin & Huxley, 1952 a, b; Frankenhaeuser & Hodgkin, 1957: heart, Weidmann, 1955: muscle fibres, Ishiko & Sato, 1957: myelinated nerve fibre, Frankenhaeuser, 1957). Several properties of this system are similar to those of the membrane control system for the contractile mechanism described by Hodgkin & Horowicz (1960a) and in this paper.…”

Section: Discussionmentioning

confidence: 99%

The action of calcium ions on potassium contractures of single muscle fibres

Lüttgau¹

1963

The Journal of Physiology

208

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Calcium ions are considered to be necessary in reactions linking the electrical and mechanical events in muscle fibres (reviewed by Sandow, 1952). But, whereas the effect of calcium ions on excitable membranes (reviewed by Shanes, 1958) and muscle 'models' (reviewed by Hasselbach, 1962) have been fully investigated during the last ten years, less is known about how external calcium influences the process which controls the development of tension in skeletal muscle fibres. This paper aims at giving some information about the properties of this system, which is regarded as the first of several links coupling excitation and contraction. Single fibres were used to achieve a quick change of the external ion concentrations, since a delay would have impeded the analysis of the time course of the transient contractures in twitch fibres.A preliminary account of this work already has appeared (Liittgau, 1962). METHODSSingle fibres were isolated from the semitendinosus or iliofibularis muscles of Rana temporaria. After the dissection each fibre was left for about 1 hr in Ringer's solution and tested for excitability before being transferred from the dissection dish to the experimental cell. This transfer took place on a small glass plate, and movement of the fibre through an air-water interface was carefully avoided.Most of the experiments were carried out with the Perspex cell described by Hodgkin & Horowicz (1959). In early experiments a similar cell with a two-channel tap for changing the solutions was used. One tendon of the fibre was gripped in a Perspex clamp and the other was connected to a mechano-electrical transducer (RCA 5734) by a silver wire of 50 IL diameter. The fibre was stretched to 1-25 times slack length. A sarcomere distance of about 2-8!e was measured on some fibres under this condition. This was made at the end of the experimental procedure with a microscope fitted with a water-immersion objective.The lengths of the fibres varied from 1.0 to 2-5 cm and the diameter (stretched) from 50 to 130 ,.The flow rate was adjusted so that all the fluid in the cell was replaced at least every half second. Membrane potentials were measured with intracellular micro-electrodes of the Ling-Gerard type.Solution&. (Table 1) The fibres were dissected in a phosphate-buffered Ringer's solution (Adrian, 1956). During the experiments solutions containing 4 mM bicarbonate gassed

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The Effect of Calcium Ions on Electrical Properties of Striated Muscle Fibres

Cited by 67 publications

References 5 publications

Effects of calcium on the conductance change of the end‐plate membrane during the action of transmitter

Effects of calcium on the conductance change of the end‐plate membrane during the action of transmitter

The role of resting potential changes in the contractile failure of frog sartorius muscles during calcium deprivation

The action of calcium ions on potassium contractures of single muscle fibres

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