The Effect of Caffeic Acid Phenethyl Ester on Bacterial Translocation and Intestinal Damage in Cholestatic Rats

Abstract

We investigated the effect of caffeic acid phenethyl ester in rat ileum injury induced by chronic biliary obstruction. Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, common bile duct ligation (n = 7); and Group 3, common bile duct ligation plus caffeic acid phenethyl ester (n = 7). In the caffeic acid phenethyl ester-treated rats, ileum tissue levels of malondialdehyde and myeloperoxidase were significantly lower than those of the bile duct-ligated rats (P < 0.001). The levels of tumor necrosis factor-alpha, interleukin-6, and interleukin-1alpha in the caffeic acid phenethyl ester group were significantly lower than those in the bile duct ligation group (P < 0.03, P < 0.01, and P < 0.02 respectively). The present study demonstrates that intraperitoneal administration of caffeic acid phenethyl ester in bile duct-ligated rats reduces intestinal oxidative stress. This effect may be useful in the preservation of intestinal damage in cholestasis.

Propolis reduces bacterial translocation and intestinal villus atrophy in experimental obstructive jaundice

“…In another study, it was shown that WSDP treatment induced extensive proliferation of nucleated cells in the spleen and bone marrow, which are mainly macrophages and hematopoietic cells [17] . Ara et al [27] found that intraperitoneal administration of CAPE reduced tissue levels of malondialdehyde and myeloperoxidase, but increased levels of glutathione in the ileum after bile duct ligation. Additionally, CAPE decreased interleukin-1α, interleukin-6, tumor necrosis factor-α, and intestinal mucosal injury, but the effect of CAPE on bacterial translocation was not revealed.…”

The Effect of Caffeic Acid Phenethyl Ester (CAPE) Against Cholestatic Liver Injury in Rats

“…It has anti-inflammatory, immunomodulatory, antiproliferative, and antioxidant properties and have been shown to inhibit lipo-oxygenase activities as well as to suppress lipid peroxidation [6][7][8][9]. Also, it has been previously shown that intraperitoneal administration of caffeic acid phenethyl ester in bile duct-ligated rats reduces intestinal oxidative [10]. To date, there is no reported study regarding the effect of CAPE on cholestatic liver damage.…”

Impact of bacterial translocation in calves with atresia coli

“…The translocation of obligate anaerobic bacteria (such as Bacteriodes and Fusobacterium ) is rarely observed . In an experimentally induced intestinal obstruction model in rats, the most commonly isolated bacteria from MLNs were found to be E. coli , P. mirabilis , and Enterococcus spp . El Awady et al reported that E. coli was the most commonly translocated bacteria.…”