The effect of Ca2+ channel antagonists (cadmium, ω-conotoxin GIVA, and nitrendipine) on the release of angiotensin II from fetal rat brain in vitro

Gadbut, Albert P.; Cash, S.A.; Noble, Janelle A.; Radice, T.R.; Weyhenmeyer, James A.

doi:10.1016/0304-3940(91)90165-p

Cited by 4 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, Ang II and Ang-(1–7) are the most widely studied in the brain of adult rats and dogs (Phillips and Stenstrom, 1985; Schiavone et al, 1990; Ferrario et al, 1991; Krob et al, 1998). In rat fetuses at GD 20, Ang II was formed and released from primary cultures in brain cells such as neurons (Weyhenmeyer et al, 1980; Gadbut et al, 1991). During the past decade, a series of studies, including ours, have demonstrated physiological functions of Ang II in the ovine fetal brain, at both near-term and pre-term (El-Haddad et al, 2000, 2001, 2002, 2005; Shi et al, 2004a,c; Xu et al, 2003, 2004, 2005).…”

Section: Components Of the Fetal Brain Ras During Developmentmentioning

confidence: 99%

Development of fetal brain renin–angiotensin system and hypertension programmed in fetal origins

Mao

Shi

et al. 2009

Progress in Neurobiology

View full text Add to dashboard Cite

Since the concept of fetal origins of adult diseases was introduced in 1980s, the development of the renin-angiotensin system (RAS) in normal and abnormal patterns has attracted attention. Recent studies have shown the importance of the fetal RAS in both prenatal and postnatal development. This review focuses on the functional development of the fetal brain RAS, and ontogeny of local brain RAS components in utero. The central RAS plays an important role in the control of fetal cardiovascular responses, body fluid balance, and neuroendocrine regulation. Recent progress has been made in demonstrating that altered fetal RAS development as a consequence of environmental insults may impact on "programming" of hypertension later in life. Given that the central RAS is of equal importance to the peripheral RAS in cardiovascular regulation, studies on the fetal brain RAS development in normal and abnormal patterns could shed light on "programming" mechanisms of adult cardiovascular diseases in fetal origins.

show abstract