The effect of CA1 dopaminergic system in harmaline-induced amnesia

Nasehi, Mohammad; Ketabchi, M.; Khakpai, Fatemeh; Zarrindast, Mohammad Reza

doi:10.1016/j.neuroscience.2014.11.012

Cited by 15 publications

(11 citation statements)

References 77 publications

(108 reference statements)

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“…Previous behavioral studies such as step-down passive avoidance test, spontaneous eye blink rates, object recognition task, have shown a number of different effects for harmaline, such as alteration in associative memory and learning with a resultant increase in neuronal excitability (Dahhaoui et al , 1992, Moura et al , 2006, Nasehi et al , 2015b, Nasehi, Piri, 2010. Harmaline…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor

Abbassian

Esmaeili

Tahamtan

et al. 2016

Physiology & Behavior

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Cognitive and motor disturbances are serious consequences of tremor induced by motor disorders. Despite a lack of effective clinical treatment, some potential therapeutic agents have been used to alleviate the cognitive symptoms in the animal models of tremor. In the current study, the effects of WIN55, 212-2 (WIN), a cannabinoid receptor (CBR) agonist, on harmaline-induced motor and cognitive impairments were studied. Adult rats were treated with WIN (0.5mg/kg; i.p.) 15min before harmaline administration (10mg/kg; ip) after which exploratory and anxiety related behaviors, and cognitive function were assessed using open-field behavior and shuttle box tests. Rats that received harmaline only exhibited a markedly reduced number of central square entries when compared to harmaline vehicle-treated controls, whereas those treated with WIN and harmaline showed a significant increase in central square entries, compared to harmaline only treated. The passive avoidance memory impairments observed in harmaline treated rats, was reversed somewhat by administration of WIN. The neuroprotective and anxiolytic effects of WIN demonstrated in the current study can be offered cannabinoid receptor (CBR) agonism as a potential neuroprotective agent in the treatment of patients with tremor that manifest mental dysfunctions.

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Section: Accepted Manuscriptmentioning

confidence: 99%

“…Nasehi et al (2015) suggested harmaline through reduction of neuron excitation could decrease memory acquisition (Nasehi et al , 2015c).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor

Abbassian

Esmaeili

Tahamtan

et al. 2016

Physiology & Behavior

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“…Bilateral stainless steel guide cannulae (22 gauge) were implanted 1 mm above the CA1 regions of the dorsal hippocampi according to the stereotaxic coordinates; AP, − 2 mm posterior to the bregma; L, ± 1.6 mm from midline; V, −1.5 mm relative to dura (Paxinos, 2001). The cannulae were anchored to the skull by means of dental cement, after which stainless steel stylets (27 gauge) were inserted into the guide cannulae to maintain patency prior to microinjections (Nasehi et al, 2015a;Nasehi et al, 2015b).…”

Section: Surgerymentioning

confidence: 99%

The hippocampal NMDA receptors may be involved in acquisition, but not expression of ACPA-induced place preference

Nasehi

Sharaf-Dolgari

Ebrahimi-Ghiri

et al. 2015

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Locomotion index was measured as the number of crossings from one square to another during a 5-min period (Nasehi, Ketabchi, Khakpai, and Zarrindast, 2015).…”

Section: Measurement Of the Locomotor Activitymentioning

confidence: 99%

The effect of CA1 α2 adrenergic receptors on memory retention deficit induced by total sleep deprivation and the reversal of circadian rhythm in a rat model

Norozpour

Nasehi

Sabouri-Khanghah

et al. 2016

Neurobiology of Learning and Memory

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The effect of CA1 dopaminergic system in harmaline-induced amnesia

Cited by 15 publications

References 77 publications

Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor

Cannabinoid receptor agonism suppresses tremor, cognition disturbances and anxiety-like behaviors in a rat model of essential tremor

The hippocampal NMDA receptors may be involved in acquisition, but not expression of ACPA-induced place preference

The effect of CA1 α2 adrenergic receptors on memory retention deficit induced by total sleep deprivation and the reversal of circadian rhythm in a rat model

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