The Effect of Bovine Growth Hormone, Desoxycorticosterone Acetate, and Cortisone Acetate on the White Blood Cell Counts of 2-Week-Old Chickens

Glick, Bruce

doi:10.3382/ps.0401537

Cited by 17 publications

(8 citation statements)

References 9 publications

(8 reference statements)

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“…Desoxycorticosterone acetate had a similar effect (Glick, 1961). Growth hormone alone did not influence the differential or the total leukocyte count.…”

Section: Number Of Leukocytessupporting

confidence: 53%

Blood: Physical Characteristics, Formed Elements, Hemoglobin, and Coagulation

Sturkie¹,

Griminger²

1976

Avian Physiology

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“…Desoxycorticosterone acetate had a similar effect (Glick, 1961). Growth hormone alone did not influence the differential or the total leukocyte count.…”

Section: Number Of Leukocytessupporting

confidence: 53%

Blood: Physical Characteristics, Formed Elements, Hemoglobin, and Coagulation

Sturkie¹,

Griminger²

1976

Avian Physiology

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“…Several investigators have found that exogenous ACTH and glucocorticoids will induce heterophilia and lymphopenia in domestic fowl (Shapiro and Schechtman, 1949;Newcomer, 1958;Siegel, 1968;Gross et al, 1980). Other researchers (Huble, 1955;Newcomer, 1957;Glick, 1961;Rusu and Cooper, 1975) have reported a substantial heterophilia with no change in lymphocyte counts after administering ACTH or cortisone acetate, or both. Thus, absolute heterophil counts appear to be very sensitive to changes in the circulating levels of the corticosteroids; lymphocyte numbers respond to a lesser extent.…”

Section: Resultsmentioning

confidence: 91%

“…In earlier studies, a leucopenia developed in hens after injections with adrenal cortical extracts (Shapiro and Schechtman, 1949) and in chicks after treatments with ACTH and Cortisol (Siegel, 1968). Other researchers (Newcomer, 1957;Glick, 1961;Rusu and Cooper, 1975) induced leucocytosis in chickens by administering ACTH and glucocorticoids.…”

Section: Resultsmentioning

confidence: 92%

Research Note: Physiological Effects of Adrenocorticotropic Hormone and Hydrocortisone in Laying Hens

1989

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To study the hormonal effects on hematologic parameters as indicators of chronic stress, exogenous adrenocorticotropin (ACTH) at 6.3 or 20.0 IU/kg/day and hydrocortisone at .25 or 2.5 mg/kg/day were administered parenterally to laying hens. Both ACTH treatments induced significant (P less than .05) heterophilia, monocytosis, eosinophilia, and basophilia. Significantly elevated leucocyte counts and lymphopenia (P less than .05) were observed with the high dosage of ACTH. Both hydrocortisone-treated groups developed an absolute lymphopenia and heterophilia (P less than .05). The low dosage of hydrocortisone induced a significant (P less than .05) monocytosis; the high dosage caused significant (P less than .05) decreases in the total eosinophil and basophil counts as well as an increase in the ratio of heterophils to lymphocytes. The hemopoietic parameters, especially heterophil counts, were sensitive indicators of a hormonal stress response induced by the administration of ACTH and hydrocortisone.

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“…Effect of glucocorticoids on immune response has been a subject of investigation in many laboratories, and although some of the results conflict, it is generally accepted that glucocorticoids inhibit both cell-mediated (Sato and Glick, 1970;North, 1971;Clamans, 1972) and humoral responses (Thaxton and Siegel, 1973;Gross and Siegel, 1980) as well as inducing leukocytosis (Newcomer, 1958;Glick, 1961), involution of the bursa (Glick, 1964), and lymphopenia and heterophillia (Glick, 1958). This wide variety of effects led Baxter and Harris (1975) to conclude that glucocorticoids have been implicated in having effects on every parameter of the immune response.…”

Section: Discussionmentioning

confidence: 99%

Effect of Corticosterone on the Incidence of Amelanosis in Smyth Delayed Amelanotic Line Chickens

1987

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The Smyth Delayed Amelanotic (SDA) line chicken exhibits a postnatal loss of pigment in feathers and choroid presumably due to an autoimmune reaction triggered by a basic pigment cell defect. The present study was designed to determine if the incidence and severity of amelanosis would be affected by administration of corticosterone (CS) in feed. The SDA line chickens were given 0, 20, 30, 40, and 50 ppm CS from 4 to 12 weeks of age. Body weight and incidence of amelanosis were determined weekly and immune response to sheep red blood cells was determined at the end of the trials. Body weight and immune response levels were significantly lower in treated groups than in controls (P less than .001), but no significant differences were found between treated groups on measures of amelanosis or immune response. Incidence of amelanosis in controls (60%) was significantly greater than in treated groups: 20 ppm, 14.2%; 30 ppm, 17.9%; 40 ppm, 12.9%; and 50 ppm, 16.7%. Six weeks posttreatment, treated groups were no longer significantly different from controls in terms of the incidence of amelanosis. It is proposed that the reduction in amelanosis during CS treatment is attributable to suppression of antibody response to the pigment cell antigen by the CS.

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The Effect of Bovine Growth Hormone, Desoxycorticosterone Acetate, and Cortisone Acetate on the White Blood Cell Counts of 2-Week-Old Chickens

Cited by 17 publications

References 9 publications

Blood: Physical Characteristics, Formed Elements, Hemoglobin, and Coagulation

Blood: Physical Characteristics, Formed Elements, Hemoglobin, and Coagulation

Research Note: Physiological Effects of Adrenocorticotropic Hormone and Hydrocortisone in Laying Hens

Effect of Corticosterone on the Incidence of Amelanosis in Smyth Delayed Amelanotic Line Chickens

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