The effect of bovine colostrum on viral upper respiratory tract infections in children with immunoglobulin A deficiency

Patıroğlu, Türkan; Kondolot, Meda

doi:10.1111/j.1752-699x.2011.00268.x

Cited by 38 publications

(56 citation statements)

References 24 publications

(42 reference statements)

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“…The immunoglobulins, lactoferrin and cytokines in colostrum are reported to show strong antiviral activity [56]. However, a double-blind, placebocontrolled study to evaluate the effect of BC on viral upper respiratory tract infections in IgA-deficient children failed to demonstrate a difference between salivary IgA levels between the control and test group, although the BC group did record a lower infection severity score [57]. Such studies remain to be conducted in similar adult patients along with elucidation of relevant mechanisms although the ones given below could be at work.…”

Section: Viral and Bacterial Illnessesmentioning

confidence: 90%

Bovine colostrum: an emerging nutraceutical

Bagwe¹,

Tharappel²,

Kaur³

et al. 2015

Journal of Complementary and Integrative Medicine

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Nutraceutical, a term combining the words "nutrition" and "pharmaceuticals", is a food or food product that provides health benefits as an adjuvant or alternative therapy, including the treatment and prevention of infectious diseases in children and adults. There is emerging evidence that bovine colostrum (BC) may be one of the promising nutraceuticals which can prevent or mitigate various diseases in newborns and adults. Immunity-related disorders are one of the leading causes of mortality in the world. BC is rich in immunity, growth and antimicrobial factors, which promote tissue growth and the maturation of digestive tract and immune function in neonatal animals and humans. The immunoglobulins and lactoferrin present in colostrum are known to build natural immunity in newborns which helps to reduce the mortality rate in this population. Also, the side-effect profile of colostrum proteins and possible lactose intolerance is relatively less in comparison with milk. In general, BC is considered safe and well tolerated. Since colostrum has several important nutritional constituents, well-designed, double-blind, placebo-controlled studies with colostrum products should be conducted to widen its therapeutic use. The objectives of this review are to create awareness about the nutraceutical properties of colostrum and to discuss the various ongoing alternative treatments of colostrum and its active ingredients as well as to address colostrum's future nutraceutical and therapeutic implications in humans.

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Section: Viral and Bacterial Illnessesmentioning

confidence: 90%

Bovine colostrum: an emerging nutraceutical

Bagwe¹,

Tharappel²,

Kaur³

et al. 2015

Journal of Complementary and Integrative Medicine

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“…Our results were in agreement with previous reports. [3,18–21] Uchida et al [19] demonstrated that ingestion of BC (6 to 7 days postpartum) significantly reduces the mean frequency of URTI and days of illness with fever in 3- to 6-year-old children compared with the placebo group. In a double blind, placebo-controlled, randomized trial, Brinkworth and Buckley [20] retrospectively pooled data from several previous studies examining self-reported URTI symptoms in 174 healthy adult males receiving BC or a whey-protein-based control supplement.…”

Section: Discussionmentioning

confidence: 99%

“…After BC therapy, the percentage reduction in the number of episodes of URTI from baseline was 73.01%, 83.25%, and 91.19% at 4, 8, and 12 weeks, respectively. Patıroğlu and Kondolot [3] studied the administration of an oral lozenge containing 14 mg of colostrum and 2.2 mg of lysozyme or a placebo lozenge 3 times per day for 1 week in 31 children aged 5 to 16 years with known IgA deficiency and clinical signs of URTI. The presence of viral infection was determined clinically, and etiologies were not confirmed by laboratory investigation.…”

Section: Discussionmentioning

confidence: 99%

“…[2–4] BC is homologous to human colostrum although immune factors are present in greater concentrations. [2,3] This hyperimmune BC, rich in targeted IgG, is different from the conventional antimicrobials as it does not disturb the integrity of the gut microflora, nor will it potentially lead to the emergence of new antibiotic-resistant organisms. [2,5] After collection, BC may be used in liquid form in its entirety, or the immunoglobulin component may be purified and fractionated into a solid concentrate.…”

Section: Introductionmentioning

confidence: 99%

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Effects of bovine colostrum on recurrent respiratory tract infections and diarrhea in children

et al. 2016

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Background:Bovine colostrum (BC) has direct antimicrobial and endotoxin-neutralizing effects throughout the alimentary tract, as well as other bioactivities that suppress gut inflammation and promote mucosal integrity and tissue repair under various conditions related to tissue injury. The precise role of BC in respiratory and gastrointestinal (GI) infections in children is not well defined. The aim of this study was to evaluate the efficacy and tolerability of BC administration in preventing recurrent upper respiratory tract infections (URTI) and diarrhea in children.Methods:One hundred sixty children (aged 1–6 years) having recurrent episodes of URTI or diarrhea received BC for 4 weeks. The number of episodes of URTI, diarrhea, and frequency of hospitalization required for URTI and diarrhea occurring during the study period were assessed at weeks 8 and 24.Results:From a total number of 160 children, 81 patients (50.63%) were males. The mean age (± SD) was 3.65 (± 2.01) years. The mean (± SD) total number of infections was significantly decreased after BC therapy from 8.6 ± 5.1 at baseline to 5.5 ± 1.2 after 2 months (P < 0.001) and to 5.7 ± 1.6 after 6 months (P < 0.001). The mean (± SD) total number of URTI (P < 0.0001), number of episodes of diarrhea (P < 0.001), and number of hospital admissions (P < 0.001) were significantly decreased after BC therapy.Conclusion:BC is effective in the prophylaxis of recurrent URTI and diarrhea as it reduces the number of episodes and the hospitalization due to these infections. Results of this study suggest that BC could be provided as a therapeutic option for children with recurrent URTI and diarrhea.

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“…Likewise, some studies have observed increases in resting salivary SIgA concentration or output after colostrum supplementation whereas others have not. [141][142][143][144][145][146][147] Bovine colostrum supplementation has also be shown to reduce or blunt the increase in intestinal permeability induced by heat stress or the administration of non-steroidal antiinflammatory drugs (NSAIDs, which are known to have detrimental effects on the gut). [148][149][150] As previously mentioned, in vitro (and ex vivo) markers of immune function are valuable to help identify potential mechanisms of action but in vivo and clinically relevant markers are more valuable.…”

Section: Dairy-derived Supplements or Functional Foods (Probiotics Bmentioning

confidence: 99%

Nutritional and Physical Activity Interventions to Improve Immunity

Davison

Kehaya

Jones

2014

American Journal of Lifestyle Medicine

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Physical activity and nutrition are important in a healthy lifestyle with potential benefits to immunity often overlooked. Infection of the upper respiratory tract, and the associated symptoms, are the most frequent presentations to general practitioners and may have significant economic and social impact. In this review, we consider the role of physical activity and nutrition in improving immunity. Evidence suggests that regular moderate activity is particularly beneficial for immune enhancement and reducing the risk of infection. We also discuss some nutritional strategies. Unfortunately, the evidence for many is weak. Avoiding nutritional deficiencies seems the most pragmatic recommendation. This can be achieved with a balanced diet. Including a variety of fruits and vegetables may help ensure adequate intake of essential nutrients with little risk of excess intake of any single nutrient. Supplementation with individual nutrients is generally not recommended. Multinutrients may be beneficial for those with a preexisting deficiency but not if normal dietary intake is sufficient. Further benefit may be gained from some supplements including probiotics, bovine colostrum, and some plant-derived products (Echinacea, black elderberry, and some polyphenols) but only in specific situations/contexts. Individuals should consider their personal needs, use caution, and avoid the indiscriminate use of supplements.

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The effect of bovine colostrum on viral upper respiratory tract infections in children with immunoglobulin A deficiency

Abstract: This is the first study to evaluate the effect of bovine colostrum in IgA-deficient children, and no adverse effects were observed. However, further studies are needed to confirm the efficacy and safety of bovine colostrum in IgA-deficient patients.

Cited by 38 publications

References 24 publications

Bovine colostrum: an emerging nutraceutical

Bovine colostrum: an emerging nutraceutical

Effects of bovine colostrum on recurrent respiratory tract infections and diarrhea in children

Nutritional and Physical Activity Interventions to Improve Immunity

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