The Effect of Botulinum Toxin A on Fat Graft Survival

Baek, Rong Min; Park, Seong Oh; Jeong, Eun Jeong; Oh, Hyun Sook; Kim, Suk Wha; Minn, Kyung Won; Lee, Sam Yong

doi:10.1007/s00266-011-9864-z

Cited by 32 publications

(26 citation statements)

References 23 publications

(23 reference statements)

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“…The former includes oxygen therapy, ischemia limiting actions and oral supplements. Local enhancement techniques include the use of platelet-rich plasma [2], adiposederived stem cells ex vivo expansion [3], adipose-derived stem cells filters and local pretreatment with botulinum toxin [4], among others.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Hyaluronic Acid Fat Grafts, Histological Findings and Specific Markers

Torres¹,

Nuciforo²,

Bonanno³

2017

JDC

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Fat grafts have become particularly popular in recent years due to their autologous origin, permanent volumetric and regenerative properties. Different attempts in improving the re-absorption rate through manipulation or enhancement are possible.Hyaluronic acid is one of the agents that could improve the outcome of the treatment given its natural anticoagulant and volume stabilizer actions. A new HA dermal filler Varioderm (Adoderm GmbH, Germany, concentration 12 mg/ml) was used to enhanced the fat grafts prior to inoculation.Samples of the enhanced grafts were extracted for laboratory analysis, cytometry, staining and markers analysis. Control fat grafts were taken, to compare the results.Histologic findings show better cytoarchitecture, less cellular rupture and inflammation in the HA enhanced fat graft.The former findings show that fat graft enhancement through HA can be a promising way to potentiate the action of the graft prior to inoculation.

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Section: Discussionmentioning

confidence: 99%

Enhanced Hyaluronic Acid Fat Grafts, Histological Findings and Specific Markers

Torres¹,

Nuciforo²,

Bonanno³

2017

JDC

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“…It has also been used since 1990 in facial cosmetics and has recently been successfully used in the treatment of hyperhidrosis, hypersialorrhea, Frey syndrome, facial asymmetries, and platysmal bands. 2,9,14,15 It is applied to the pectoral muscles after subpectoral implant placements, which induces reversible denervation and better cosmetic result as well as a painless postoperative period. 2,9,13,15,[17][18][19][20][21][22][23] Moreover, in experimental studies, BTX-A application prevented contraction of muscle flaps by which it could allow the stabilization of muscle flaps.…”

Section: Botox Informationmentioning

confidence: 99%

“…In 1822, Hauben et al, 1 for the first time, used a skin graft obtained from the thigh region for nasal reconstruction, but it is well known that Baronio had already performed experimental skin graft applications on sheep. [1][2][3][4] In all skin grafts, contraction occurs in the healing period, and because of these contractions, esthetically unpleasant views and loss of function from lack of movement over the joints may occur. Although some long-term splint applications are advised, there is no definitive treatment to prevent these contractions.…”

mentioning

confidence: 99%

The Effects of Botulinum Toxin A on the Wound and Skin Graft Contraction

Kucukkaya¹,

Irkoren²,

Ozkan³

et al. 2014

Journal of Craniofacial Surgery

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“…The mastery of this technical modifications, which affect our graft, together with the understanding of recipient site [15][16][17] and systemic factors, will allow us to get long lasting and reproducible results for the benefit of our patients.…”

Section: Discussionmentioning

confidence: 99%

Differential fat harvesting

Farr¹,

Trivisonno²

2014

Plast Aesthet Res

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Aim: Volume replacement with fi llers is regularly performed with the use of diverse volumetric materials to correct different structures around the face, depending on the volume enhancement required and the thickness of the soft tissue envelope. Differential fat harvesting and posterior grafting is performed to place the correct fat parcel size for each target area, expanding the potential applications of fat. Methods: Sixty patients consecutively recruited on a fi rst come basis undergone a facial fat grafting procedure, in private practice setting between March 2012 and October 2013. Fat grafting quantity and quality was predicted for each case. Differential harvesting was performed, with 2 fat parcels size. Processing was performed through washing. Fat infi ltration was carried out through small cannulas or needles depending on the treated area. Outcomes were analysed both by the physicians and the patients at 7 days, 1 month, 3 months and 6 months through a perceived satisfaction questionnaire. Parameters considered were downtime or discomfort, skin benefi ts, volume restoration, reabsorption rate estimated and overall improvement. Results: Full facial differential fat grafting procedure lasted an average of 1.5-2.5 h. Average downtime was 3-4 days. Follow-up was performed to a minimum of 6 months. Both patient and physician overall satisfaction rates were mostly excellent. Adverse events like lumps or irregularities were not encountered. Conclusion: Differential fat harvesting and posterior grafting is a valid alternative, to expand the repertoire of fat use, allow a more homogeneous effect, reduce the potential complications, speed up the process, improve graft survival, and to enhance overall aesthetic outcome.

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The Effect of Botulinum Toxin A on Fat Graft Survival

Abstract: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors at www.springer.com/00266.

Cited by 32 publications

References 23 publications

Enhanced Hyaluronic Acid Fat Grafts, Histological Findings and Specific Markers

Enhanced Hyaluronic Acid Fat Grafts, Histological Findings and Specific Markers

The Effects of Botulinum Toxin A on the Wound and Skin Graft Contraction

Differential fat harvesting

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