The effect of bone mass and architecture on mandibular condyle after mandibular distraction

Suda, Daisuke; Ohazama, Atsushi; Maeda, Takeyasu; Kobayashi, Tadaharu

doi:10.1016/j.oooo.2017.05.472

Cited by 8 publications

(3 citation statements)

References 29 publications

(25 reference statements)

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“…In a previous study, Xi et al21 reported that almost half of patients who underwent bilateral sagittal split osteotomy (BSSO) advancement surgery experienced condylar resorption. Previous animal experiments revealed the factor responsible for condylar resorption was over loading 22. However, the long axis and short axis of the affected condyle, the height of the coronoid process, the distance between the condyle and the coronoid process, and the angle of the mandibular notch, remained unchanged.…”

Section: Discussionmentioning

confidence: 93%

“…Previous animal experiments revealed the factor responsible for condylar resorption was over loading. 22 However, the long axis and short axis of the affected condyle, the height of the coronoid process, the distance between the condyle and the coronoid process, and the angle of the mandibular notch, remained unchanged. When comparing the ratios of the volume and height of the affected and unaffected condyle before MDO, we identified significant differences; these results were the same as those before MDE.…”

Section: Discussionmentioning

confidence: 94%

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Morphologic Changes of the Temporomandibular Joint in Pruzansky-Kaban Type IIa Hemifacial Microsomia Postmandibular Distraction Osteogenesis

Shu

Liu

Zhao

et al. 2022

Journal of Craniofacial Surgery

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Objective: Mandibular distraction osteogenesis (MDO) is a powerful tool for the correction of hemifacial microsomia (HFM). The temporomandibular joint (TMJ) is the focus of attention in the diagnosis and treatment of HFM. This observational retrospective cross-sectional study aimed to investigate morphologic changes in TMJ post-MDO in type IIa HFM. Methods: We recruited 48 patients with unilateral type IIa HFM who had completed MDO and mandibular distractor extraction (MDE). Data relating to the length, distance, angle, and volume of the TMJ were measured on 3-dimension models created by the analysis of computed tomography data. Normality analysis was performed by using the Shapiro-Wilk test. Data were compared with the paired t test and Wilcoxon signed-ranks test. Results: The spaces between the affected condyle and the affected glenoid fossa before MDO were all significantly larger than before MDE (P<0.05). The breadth of the affected glenoid fossa before MDO was significantly longer than before MDE (P<0.001). The height of the affected condyle before MDO was significantly longer than before MDE (P<0.001). The volume of the affected condyle before MDO was significantly larger than before MDE (P<0.001). The ratio between the volume of the affected condyle and unaffected condyle before MDO was 0.20±0.13. The ratio between the volume of the affected condyle before MDE and MDO was 0.65±0.32. The resorption rate of the affected condyle post-MDO was 0.35±0.32. Conclusion: Herein, we characterized anatomic changes of the TMJ in type- IIa HFM post-MDO. Condylar resorption and the compression of space between the condyle and the glenoid fossa on the affected side were 2 typical manifestations. Our findings enhanced the understanding of the application of MDO on HFM.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Morphologic Changes of the Temporomandibular Joint in Pruzansky-Kaban Type IIa Hemifacial Microsomia Postmandibular Distraction Osteogenesis

Shu

Liu

Zhao

et al. 2022

Journal of Craniofacial Surgery

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“…Similar to experimental studies, we identified BD as a factor contributing to TMJ degenerative change. 31 Previous studies have demonstrated that preoperative TMJ conditions may influence the outcomes of MDO or orthognathic surgery. Fan et al reported that syndromic micrognathia patients who suffered from more abnormalities before treatment were prone to condylar pathology and TMJ ankylosis.…”

Section: Discussionmentioning

confidence: 99%

Bone Density of the Condyle of Children with Craniofacial Microsomia and its Correlation with Condylar Resorption After Mandible Distraction Osteogenesis

Zhang

Tang

et al. 2023

The Cleft Palate Craniofacial Journal

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Objective To investigate condylar bone density (BD) in children with craniofacial microsomia (CFM) and identify factors that contribute to early stage condylar resorption (CR) after mandibular distraction osteogenesis (MDO). Design Retrospective study. Setting Craniofacial department of a plastic surgery hospital. Patients Fifty-one children with CFM classified as Pruzansky IIa based on complete pre-(T0) and post-MDO (T1) computed tomography (CT) data. Intervention and Main outcome measurements Mimic 21.0 (Materialise Inc., Belgium) was used to measure bilateral BD and condylar height (CH) and volume (CV) of affected side. Children were split into groups based on either affected side BD or the distraction length (DL,25 mm as cutoff) .Bilateral BD was compared using a paired t-test in each group. The CH and CV of affected side at T0 and T1 were compared. The relative values of the CH and CV (CH ratio) and the volume (CV ratio) of the affected side were compared across the groups. Results The BD was lower on affected side than on unaffected side. Regarding BD, CH and CV decreased after MDO in group I, while the CH ratio and CV ratio of group I was lower than that of groups II and III. Regarding DL, the CV ratio was lower in Group L than Group S. Conclusions The condylar bone quality on affected side is compromised in type IIa CFM. A low BD in combination with a larger distraction distance may increase the risk of CR; therefore, MDO in patients with such characteristics should be postponed.

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Conditioned medium from mesenchymal stem cells improves condylar resorption induced by mandibular distraction osteogenesis in a rat model

Katagiri

Endo

Takeuchi

et al. 2021

Heliyon

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Condylar resorption (CR) after surgical orthognathic treatment is defined as dysfunctional remodeling of the temporomandibular joint manifested by morphological changes with decreased condylar head volume that cause occlusal and esthetic changes. Although both conservative and surgical treatment strategies have been employed for the treatment of CR, effective procedures have not been established till date. In this study, the effects of MSC-CM on CR were investigated. Bone marrow-derived MSCs of rats (rMSCs) were cultured until 80% confluent, cultured in serum-free conditioned medium for 48 h; the collected medium was defined as MSC-CM. Osteogenesis, chondrogenesis, and angiogenesis-related gene expression in rMSCs cultured with MSC-CM was evaluated by quantitative real-time polymerase chain reaction. A rat CR model was used for animal studies, in which CR occurred after mandibular distraction osteogenesis for 10 days. MSC-CM was injected via the tail vein and quantitative and qualitative evaluations were performed by micro-computed tomography (micro-CT) and histology. MSC-CM enhanced osteogenesis-, chondrogenesis-, and angiogenesis-related gene expression in rMSCs. Micro-CT showed CR in control groups; however, it was observed to be improved in the MSC-CM group. Histologically, an enlarged cartilage layer was seen in the MSC-CM group, while cartilage layers had almost thinned or disappeared in control groups. These results indicate that MSC-CM improved CR.

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The effect of bone mass and architecture on mandibular condyle after mandibular distraction

Abstract: These results suggest that bone mass and architecture strongly affect the tolerance to the overloading and adaptation with bone apposition in condylar resorption site.

Cited by 8 publications

References 29 publications

Morphologic Changes of the Temporomandibular Joint in Pruzansky-Kaban Type IIa Hemifacial Microsomia Postmandibular Distraction Osteogenesis

Morphologic Changes of the Temporomandibular Joint in Pruzansky-Kaban Type IIa Hemifacial Microsomia Postmandibular Distraction Osteogenesis

Bone Density of the Condyle of Children with Craniofacial Microsomia and its Correlation with Condylar Resorption After Mandible Distraction Osteogenesis

Conditioned medium from mesenchymal stem cells improves condylar resorption induced by mandibular distraction osteogenesis in a rat model

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