The Effect of Bone Marrow Mesenchymal Stem Cells Application on Distracted Bone Quality during Rapid Rate of Distraction Osteogenesis

Kassaby, Marwa El; Kader, Khaled Abd El Meneim Abd El; Khamis, Nahed Samy; Hammoud, Alaa Al; Talb, Alaa Ben; Hadidi, Yasser Nabil El

doi:10.1055/s-0037-1604070

Cited by 5 publications

(8 citation statements)

References 38 publications

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“…28,29 Previous studies delivered MSCs to the distracted bone to enhance bone formation. 11,30 However, contradicting results about the positive effect of MSCs were seen. The effect of MSCs + PRP on new bone formation after DO has been investigated in several articles.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, BMSCs are the most used stem cells for cell therapy and tissue repair 10 . BMSCs were used to enhance bone formation in distraction osteogenesis treatments 11 . In the case of RPE, Ekizer et al 12 were the first to study and analyse the effect of MSCs claiming their positive effect on sutural bone formation.…”

Section: Introductionmentioning

confidence: 99%

“…10 BMSCs were used to enhance bone formation in distraction osteogenesis treatments. 11 In the case of RPE, Ekizer et al 12 were the first to study and analyse the effect of MSCs claiming their positive effect on sutural bone formation. By using a carrier, higher numbers of stem cells will remain at the injection site.…”

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confidence: 99%

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Effect of mesenchymal stem cells with platelet‐rich plasma carriers on bone formation after rapid maxillary expansion: An Animal Study

Ebadifar

Eslamian

Motamedian

et al. 2021

Orthod Craniofacial Res

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Post-treatment relapse is the main concern regarding rapid palatal expansion (RPE) which is seen in 45% of the patients. 1,2 Considering the impact of bone density on its strength, it is essential to use retainers until mid-palatal suture reaches the proper mineral content. 3 Since retainers anchor teeth and not palatal bone, palatal osteoid tables tend to get closer, even in the retention period. 4 Therefore, accelerating palatal bone formation and maturation may decrease the duration of the retention period and the possibility of relapse. Previous studies used laser therapy, 5 vitamins 6 and mesenchymal stem cells (MSCs) to increase sutural bone formation after RPE treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of mesenchymal stem cells with platelet‐rich plasma carriers on bone formation after rapid maxillary expansion: An Animal Study

Ebadifar

Eslamian

Motamedian

et al. 2021

Orthod Craniofacial Res

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“…Critical bone defects are commonly applied in the ileum crest, being a non-weight-bearing bone with integrity to support larger defects [ 137 ]. Non-critical bone defects are those who can self-heal spontaneously, thus without compromising the bone intrinsic healing capacity, and can be applied in various bones, like the femur [ 138 , 139 ], tibia [ 140 , 141 ] and others, like the mandibular bone [ 142 , 143 ].…”

Section: Small Ruminants As Animal Models and Regenerative Medicinmentioning

confidence: 99%

Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives

Alvites

Branquinho

Sousa

et al. 2021

Biology

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Medical and translational scientific research requires the use of animal models as an initial approach to the study of new therapies and treatments, but when the objective is an exploration of translational potentialities, classical models fail to adequately mimic problems in humans. Among the larger animal models that have been explored more intensely in recent decades, small ruminants, namely sheep and goats, have emerged as excellent options. The main advantages associated to the use of these animals in research works are related to their anatomy and dimensions, larger than conventional laboratory animals, but very similar to those of humans in most physiological systems, in addition to their low maintenance and feeding costs, tendency to be docile, long life expectancies and few ethical complications raised in society. The most obvious disadvantages are the significant differences in some systems such as the gastrointestinal, and the reduced amount of data that limits the comparison between works and the validation of the characterization essays. Despite everything, recently these species have been increasingly used as animal models for diseases in different systems, and the results obtained open doors for their more frequent and advantageous use in the future. The purpose of this review is to summarize the general principles related to the use of small ruminants as animal models, with a focus on regenerative medicine, to group the most relevant works and results published recently and to highlight the potentials for the near future in medical research.

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“…Critical bone defects are commonly applied in the ileum crest, being a non-weight-bearing bone with integrity to support larger defects (131). Non-critical bone defects can be applied in various bones, like the femur (132,133), tibia (134,135) and others, like the mandibular bone (136,137). Furthermore, sheep and goat at a lesser extent are reliable animal models of osteoporosis for preclinical and translational studies to humans.…”

Section: Osteoarticular Systemmentioning

confidence: 99%

Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives.

Alvites¹,

Branquinho²,

Sousa³

et al. 2021

Preprint

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Medical and translational scientific research requires the use of animal models as an initial approach to the study of new therapies and treatments, but when the objective is an exploration of translational potentialities, classical models fail to adequately mimic problems in humans. Among the larger animal models that have been explored more intensely in recent decades, small ruminants, namely sheep and goats, have emerged as excellent options. The main advantages associated to the use of these animals in research works are related to their anatomy and dimensions very similar to those of humans in most physiological systems, in addition to their low maintenance and feeding costs, tendency to be docile, long life expectancies and few ethical complications raised in society. The most obvious disadvantages are the significant differences in some systems such as the gastrointestinal, and the reduced amount of data that limits the comparison between works and the validation of the characterization essays. Despite everything, recently these species have been increasingly used as animal models for diseases in different systems, and the results obtained open doors for their more frequent and advantageous use in the future. The purpose of this review is to summarize the general principles related to the use of small ruminants as animal models, with focus on regenerative medicine, to group the most relevant works and results published recently and to highlight the potentials for the near future in medical research.

show abstract

The Effect of Bone Marrow Mesenchymal Stem Cells Application on Distracted Bone Quality during Rapid Rate of Distraction Osteogenesis

Cited by 5 publications

References 38 publications

Effect of mesenchymal stem cells with platelet‐rich plasma carriers on bone formation after rapid maxillary expansion: An Animal Study

Effect of mesenchymal stem cells with platelet‐rich plasma carriers on bone formation after rapid maxillary expansion: An Animal Study

Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives

Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives.

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