The effect of bombesin on gastric emptying of solids in man

Scarpignato, Carmelo; Micali, B; Vitulo, F; Zimbaro, G; Bertaccini, G.

doi:10.1016/0196-9781(81)90031-0

Cited by 17 publications

(4 citation statements)

References 17 publications

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“…These data suggest that, on the whole, the motor effect of bombesin on the intestine is of less importance in comparison with the enormous capacity of the upper intestine for glucose absorption [48], In ! 982, we reported that bombesin is able to strongly delay the gastric emptying of solids in humans [45]. At the same time, Walsh et al [55] were able to demonstrate -by means of intragastric titration -that the peptide delays the gastric emptying of liquids in a doserelated manner.…”

Section: Discussionmentioning

confidence: 82%

Effect of Bombesin on Glucose-Induced Insulin Release in Humans

Scarpignato¹,

Gioffré²,

Micali³

1987

Digestion

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The effect of bombesin on basal and glucose-stimulated insulin release was studied in male healthy volunteers. Glucose was administered by oral, intravenous or intraduodenal route during saline or bombesin infusion (5 ng/kg/min for 60 min). The peptide had no significant effect on basal levels of glucose and insulin. However, during its administration, the insulin response and the expected rise in blood glucose after oral glucose load (50 g) were strongly inhibited, and the gastric emptying of liquids was significantly delayed. On the contrary, the insulin response to intravenous glucose (20 g) was significantly increased by bombesin without changes in plasma glucose levels. Finally, when glucose was infused into the duodenum, thus bypassing the stomach, the insulin response was significantly increased by the peptide. In this case, too, plasma glucose levels after glucose load were virtually identical during either bombesin or saline infusion. These data clearly demonstrate that the direct effect of bombesin on insulin release is stimulatory and suggest that the inhibitory effect observed after oral glucose is connected with the action of the peptide on gastric emptying, the delay of which slows the entry of glucose into the small bowel.

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Section: Discussionmentioning

confidence: 82%

Effect of Bombesin on Glucose-Induced Insulin Release in Humans

Scarpignato¹,

Gioffré²,

Micali³

1987

Digestion

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“…In baboons, however, reduction of food intake was achieved after administration of bombesin into the lateral cerebral ventricle, indicating that satiety mechanisms may be species speci®c (Figlewicz et al, 1986). Bombesin is a potential inhibitor of gastric emptying in humans, probably due to strong contractions of the antrum and pylorus (Scarpignato et al, 1981). This inhibition of gastric emptying may account for the satiety mechanism of bombesin in humans, although this mechanism is not operative in rats (Hostetler et al, 1989).…”

Section: Discussionmentioning

confidence: 91%

Obese women are less sensitive for the satiety effects of bombesin than lean women

et al. 1998

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Objective: The aim of this study was to investigate whether infusion of bombesin, when combined with a gastric preload, in¯uence satiety and foot intake in obese and lean healthy women. Design: Double blind, placebo controlled study. Setting: Department of Gastroenterology, Leiden University Medical Center, The Netherlands. Subjects: Obese (n 7) and lean (n 7) healthy women. Interventions: Intravenous infusion of bombesin (0.09 nmol/kg ideal weight/h) or placebo for 165 min.Gastric preload of banana slices was administered at time 60 min. Meal ingestion started at time 75 min (banana slices). Food intake was calculated and satiety was measured by visual analog scales. Results: During infusion of bombesin the amount of food eaten by the lean individuals (193 AE 37 g) was signi®cantly reduced compared to saline infusion (365 AE 42 g, P`0.05). However, bombesin induced no signi®cant feeding suppression in obese women when compared to saline (241 AE 46 vs 301 AE 45 g, respectively). The decrease in food intake during bombesin infusion compared to saline was signi®cantly greater in lean subjects (173 AE 30 g) than in obese subjects (59 AE 35 g; P`0.05). Only in lean subjects subjective preprandial hunger feelings were signi®cantly affected by bombesin infusion. Conclusions: Infusion of bombesin, when combined with a gastric preload, inhibits food intake and increases satiety in lean women. Obese women are less sensitive for these bombesin induced satiety effects. Sponsorship: This study was supported by a grant from the Dutch Organization for Scienti®c Research (NWO; grant 900-522-080). Descriptors: bombesin; satiety; food intake; obese and lean women

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“…respectively. Plasma immunoreactive gastrin (IRG) was measured as de scribed in a previous paper [28]. The intraassay coef ficient of variation of the method used is 10.0%.…”

Section: Laboratory Analysesmentioning

confidence: 99%

Effect of Bombesin on Basal and Stimulated Secretion of Some Pituitary Hormones in Humans

Pontiroli

Scarpignato

1986

Horm Res

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The effect of bombesin (5 ng/kg/min × 2.5 h) on basal pituitary secretion as well as on the response to thyrotropin releasing hormone (TRH; 200 µg) plus luteinizing hormone releasing hormone (LHRH; 100 µg) was studied in healthy male volunteers. The peptide did not change the basal level of growth hormone (GH), prolactin, thyroid-stimulating hormone (TSH), luteinizing hormone (LH) and follicle-stimulating hormone (FSH). On the contrary, the pituitary response to releasing hormones was modified by bombesin administration. When compared with control (saline) values, prolactin and TSH levels after TRH were lower during bombesin infusion, whereas LH and FSH levels after LHRH were higher. Thus bombesin affects in man, as in experimental animals, the secretion of some pituitary hormones.

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The effect of bombesin on gastric emptying of solids in man

Cited by 17 publications

References 17 publications

Effect of Bombesin on Glucose-Induced Insulin Release in Humans

Effect of Bombesin on Glucose-Induced Insulin Release in Humans

Obese women are less sensitive for the satiety effects of bombesin than lean women

Effect of Bombesin on Basal and Stimulated Secretion of Some Pituitary Hormones in Humans

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