The Effect of Bolus on Local Control for Patients Treated With Mastectomy and Radiation Therapy

Nichol, Alan; Narinesingh, Dylan; Raman, Srinivas; Germain, François; Chan, Elisa K.; Tran, Eric; Gondara, Lovedeep; Speers, Caroline; Lohrisch, Caroline; Truong, Pauline T.

doi:10.1016/j.ijrobp.2021.01.019

Cited by 25 publications

(20 citation statements)

References 29 publications

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“…Andic F et al reported that using a 1-cm thick bolus in up to 15 of the total 25 fractions increased minimum skin doses with a tolerable increase in maximum doses [ 18 ]. Use 5 mm bolus common alternate-day [ 1 , 19 ], or discontinue bolus use when patients experience a grade 2 skin toxicity (cumulated target dose was around 40–46 Gy) were reported [ 15 ]. According to these findings, we can conclude that the skin toxicity of 20 fractions with TPE bolus is similar (or lower) to those without bolus (grade 2 skin toxicity 13.3% vs 10% [ 20 ] or 40.5% [ 13 ]).…”

Section: Discussionmentioning

confidence: 99%

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Application of thermoplastic elastomer (TPE) bolus in postmastectomy radiotherapy

Gong

Dai²,

Wang³

et al. 2022

The Breast

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Section: Discussionmentioning

confidence: 99%

“…A recent study pointed out no statistically significant difference in local recurrence (LR) and breast cancer mortality with and without bolus (10-year LR was 1.9% vs 0.9%) [ 19 ]. Therefore, using bolus without large randomized controlled trials remains controversial [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Application of thermoplastic elastomer (TPE) bolus in postmastectomy radiotherapy

Gong

Dai²,

Wang³

et al. 2022

The Breast

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“…To date, various measures can be applied to minimize dosage to organs at risk whilst ensuring adequate coverage of target volumes such as deep inspiration breath hold with or without continuous positive airway pressure (CPAP) [ 50 , 51 ]. Techniques for PMRT continue to evolve and routine use of a bolus for mastectomy cases is controversial as this may be associated with increased toxicity without improving local control [ 52 ]. Therefore, current European consensus guidelines do not recommend a bolus unless deemed necessary to ensure that the therapeutic dose of irradiation adequately covers those areas at high-risk for recurrence, e.g., in skin invading cancer [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

Oncoplastic breast consortium recommendations for mastectomy and whole breast reconstruction in the setting of post-mastectomy radiation therapy

Weber

Shaw²,

Pusic

et al. 2022

The Breast

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“…Over recent years, the global incidence of breast cancer has increased; this particular cancer is now the most common global cancer 12 ; however, the molecular mechanisms underlying breast cancer have yet to be elucidated. 13 …”

Section: Discussionmentioning

confidence: 99%

A comparative study of the ability of recombinant oncolytic adenovirus, doxorubicin and tamoxifen to inhibit the proliferation of breast cancer cells

et al. 2022

J Cellular Molecular Medi

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In this study, we compared the inhibitory effects of recombinant oncolytic adenovirus (Ad‐apoptin‐hTERTp‐E1a, Ad‐VT) with that of doxorubicin (DOX), a first‐line chemotherapy drug, and tamoxifen (TAM), an endocrine therapy drug, on the proliferation of breast cancer cells. We found that Ad‐VT could effectively inhibit the proliferation of breast cancer cells ( p < 0.01); the inhibition rate of Ad‐VT on normal mammary epithelial MCF‐10A cells was less than 20%. DOX can effectively inhibit the proliferation of breast cancer cells and also has a strong inhibitory effect on MCF‐10A cells ( p < 0.01). TAM also has a strong inhibitory effect on breast cancer cells, among which the oestrogen‐dependent MCF‐7 cell inhibition was stronger ( p < 0.01), At higher concentrations, TAM also had a high rate of inhibition (>70%) on the proliferation of MCF‐10A cells. We also found that both recombinant adenovirus and both drugs could successfully induce tumour cell apoptosis. Further Western blot results showed that the recombinant adenovirus killed breast cancer cells through the endogenous apoptotic pathway. Analysis of the nude mouse subcutaneous breast cancer model showed that Ad‐VT significantly inhibited tumour growth (the luminescence rate of cancer cells was reduced by more than 90%) and improved the survival rate of tumour‐bearing mice ( p < 0.01). Compared with DOX and TAM, Ad‐VT has a significant inhibitory effect on breast cancer cells, but almost no inhibitory effect on normal breast epithelial cells, and this inhibitory effect is mainly through the endogenous apoptotic pathway. These results indicate that Ad‐VT has significant potential as a drug for the treatment of breast cancer.

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The Effect of Bolus on Local Control for Patients Treated With Mastectomy and Radiation Therapy

Cited by 25 publications

References 29 publications

Application of thermoplastic elastomer (TPE) bolus in postmastectomy radiotherapy

Application of thermoplastic elastomer (TPE) bolus in postmastectomy radiotherapy

Oncoplastic breast consortium recommendations for mastectomy and whole breast reconstruction in the setting of post-mastectomy radiation therapy

A comparative study of the ability of recombinant oncolytic adenovirus, doxorubicin and tamoxifen to inhibit the proliferation of breast cancer cells

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