The Effect of Body Mass Index on Brain Volume and Cognitive Function in Relapsing–Remitting Multiple sclerosis: A CombiRx Secondary Analysis

Ben-Zacharia, Aliza Bitton; Brody, Abraham A.; Wolinsky, Jerry S.; Lublin, Fred; Cutter, Gary

doi:10.1177/11795735211042173

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…Some studies link vascular and related traits like obesity with imaging outcomes in MS, but specific results vary ( Table 2 ) ( 55 – 57 ). For example, a higher burden of vascular comorbidities was generally associated with worse MRI outcomes in people with MS, but findings of specific comorbidities contributing to the association have varied ( 34 , 44 , 46 , 55 – 58 , 60 , 64 , 66 ). Few recent studies have examined the relationship between psychiatric comorbidities and imaging outcomes; one small study in people with MS noted lower volumes of the putamen and nucleus accumbent in people with bipolar disorder relative to without bipolar disorder ( 59 ).…”

Section: Effects Of Comorbiditiesmentioning

confidence: 99%

Etiology, effects and management of comorbidities in multiple sclerosis: recent advances

Marrie

Fisk

Fitzgerald³

et al. 2023

Front. Immunol.

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Comorbid conditions commonly affect people with multiple sclerosis (MS). Population-based studies indicate that people with MS have an increased incidence of ischemic heart disease, cerebrovascular disease, peripheral vascular disease, and psychiatric disorders as compared to people without MS. People with MS from underrepresented minority and immigrant groups have higher comorbidity burdens. Comorbidities exert effects throughout the disease course, from symptom onset through diagnosis to the end of life. At the individual level, comorbidity is associated with higher relapse rates, greater physical and cognitive impairments, lower health-related quality of life, and increased mortality. At the level of the health system and society, comorbidity is associated with increased health care utilization, costs and work impairment. A nascent literature suggests that MS affects outcomes from comorbidities. Comorbidity management needs to be integrated into MS care, and this would be facilitated by determining optimal models of care.

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Section: Effects Of Comorbiditiesmentioning

confidence: 99%

Etiology, effects and management of comorbidities in multiple sclerosis: recent advances

Marrie

Fisk

Fitzgerald³

et al. 2023

Front. Immunol.

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“…There is established literature supporting the relationship between higher BMI and aspects of MS severity, including cross‐sectional and longitudinal changes in grey matter volumes [34–39]. This is not necessarily an MS‐specific effect, as similar results, particularly between higher BMI and lower grey matter volumes, have been found in people without MS [40–48].…”

Section: Discussionmentioning

confidence: 76%

Cardiovascular risk factors in secondary progressive multiple sclerosis: A cross‐sectional analysis from the MS‐STAT2 randomized controlled trial

Williams

John

Calvi

et al. 2023

Euro J of Neurology

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Background and purpose There is increasing evidence that cardiovascular risk (CVR) contributes to disability progression in multiple sclerosis (MS). CVR is particularly prevalent in secondary progressive MS (SPMS) and can be quantified through validated composite CVR scores. The aim was to examine the cross‐sectional relationships between excess modifiable CVR, whole and regional brain atrophy on magnetic resonance imaging, and disability in patients with SPMS. Methods Participants had SPMS, and data were collected at enrolment into the MS‐STAT2 trial. Composite CVR scores were calculated using the QRISK3 software. Prematurely achieved CVR due to modifiable risk factors was expressed as QRISK3 premature CVR, derived through reference to the normative QRISK3 dataset and expressed in years. Associations were determined with multiple linear regressions. Results For the 218 participants, mean age was 54 years and median Expanded Disability Status Scale was 6.0. Each additional year of prematurely achieved CVR was associated with a 2.7 mL (beta coefficient; 95% confidence interval 0.8–4.7; p = 0.006) smaller normalized whole brain volume. The strongest relationship was seen for the cortical grey matter (beta coefficient 1.6 mL per year; 95% confidence interval 0.5–2.7; p = 0.003), and associations were also found with poorer verbal working memory performance. Body mass index demonstrated the strongest relationships with normalized brain volumes, whilst serum lipid ratios demonstrated strong relationships with verbal and visuospatial working memory performance. Conclusions Prematurely achieved CVR is associated with lower normalized brain volumes in SPMS. Future longitudinal analyses of this clinical trial dataset will be important to determine whether CVR predicts future disease worsening.

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“…За допомогою статистичних методів оцінки було проведено аналіз впливу ІМТ та об'єму кори головного мозку на когнітивні функції у пацієнтів з рецидивуючо-ремітуючим РС. Результати показали відсутність зв'язку між високим індексом маси тіла та його впливом на об'єм кори головного мозку та когнітивні функції у пацієнтів з множинним склерозом [3].…”

Section: результати обговоренняunclassified

The role of constitutional features of body structure in the occurrence and course of multiple sclerosis (literature review)

Gunas¹

2022

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The widespread prevalence of multiple sclerosis in different parts of the world among representatives of different races, nationalities, age groups, gender groups, chronic course of disease, the high cost of treatment and a significant percentage of disability of the working population makes this disease more relevant for scientific research than ever. One of the understudied aspects of domestic scientists is the anthropometric indicators іn group of patients suffering from multiple sclerosis. The aim of the study is to conduct a review a literary sources for the period 2012-2022, related to the topic of the human constitution and multiple sclerosis. A study of 29 sources that met the inclusion criteria was carried out. For the most part, the following anthropometric indicators were found in the publications, which had one or another reliable connection with the risk of occurrence or the course of multiple sclerosis: body mass index, ratio of muscles and fat in the body, waist circumference. Also important factors that were pay attention to account by the researchers and as a result in addition influenced the results of the research were: nationality, race, age and sex. According to the data of the analyzed studies, body mass index has the greatest contribution to the rate of disease progression between the studied groups with different course of multiple sclerosis, while sex had a greater influence on the occurrence of a certain specific type of course of multiple sclerosis. Accordingly to the analysis of literary sources revealed that there is a need to conduct an anthropometric study of Ukrainians suffering from multiple sclerosis in order to further form groups of key indicators that can be used to predict the risk of occurrence and course of this disease. This will become possible due to conducting a clinical and anthropological study that will be carried out in the future.

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The Effect of Body Mass Index on Brain Volume and Cognitive Function in Relapsing–Remitting Multiple sclerosis: A CombiRx Secondary Analysis

Cited by 4 publications

References 32 publications

Etiology, effects and management of comorbidities in multiple sclerosis: recent advances

Etiology, effects and management of comorbidities in multiple sclerosis: recent advances

Cardiovascular risk factors in secondary progressive multiple sclerosis: A cross‐sectional analysis from the MS‐STAT2 randomized controlled trial

The role of constitutional features of body structure in the occurrence and course of multiple sclerosis (literature review)

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