The effect of blood glucose regulation on the presence of opportunistic <i>Demodex folliculorum</i> mites in patients with type 2 diabetes mellitus

Gökçe, Cumali; Aycan-Kaya, Özlem; Yula, Erkan; Üstün, İhsan; Yengil, Erhan; Sefil, Fatih; Rizaoglu, Hatice; Gültepe, Bilge; Bayram, Fahri

doi:10.1177/0300060513494730

Cited by 36 publications

(42 citation statements)

References 30 publications

(55 reference statements)

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“…It has been reported that Demodex spp. are widespread in patients with AIDS, leukemia, cancer, diabetes, rheumatoid arthritis, and in pregnant women and hemodialysis patients [10].…”

Section: Resultsmentioning

confidence: 99%

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Demodex Parazytes in Schizophrenia

2016

Ann Clin Anal Med

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Anahtar KelimelerŞizofreni; İmmun Sistem; Ektoparazitik İnfestasyonlar Abstract Aim: Demodex parazytes are commonly present all over the world, especially in facial region of humans. Demodex spp. are assumed to be more common in schizophrenia due to partial suppression of immune system and lack of good self-care. The present study aimed to investigate the prevalence of Demodex ectoparasites in schizophrenia patients. Material and Method: In the study, 31 patients with a diagnosis of schizophrenia and 30 subjects without any psychiatric disorder or skin disease were subjected to standard superficial skin biopsy technique to determine Demodex spp. Results: Demodex spp.were found positive in nine schizophrenia patients and it was found positive in two healthy controls. Considering the prevalence of Demodex spp., a significant relationship is found between schizophrenia patients and normal controls (p<0.05). Discussion: As a result, Demodex spp. are more common in schizophrenia due conditions of reduced self-care and immunosuppression, Demodex parasites should be considered in schizophrenia patients with skin lesions, especially on the face, and should to be treated if needed.

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“…It has been reported that Demodex spp. are widespread in patients with AIDS, leukemia, cancer, diabetes, rheumatoid arthritis, and in pregnant women and hemodialysis patients [10].…”

Section: Resultsmentioning

confidence: 99%

“…Parasite concentrations may increase due to suppressed immune system in these disease manifestations [10][11][12][13]. There are studies investigating the incidence of Demodex spp.…”

Section: Resultsmentioning

confidence: 99%

Demodex Parazytes in Schizophrenia

2016

Ann Clin Anal Med

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“…A higher prevalence was also found in underweight patients (13.3%). However, Gökҫe et al [25] did not find any relationship between the prevalence of D. folliculorum and BMI.…”

Section: Epidemiologymentioning

confidence: 89%

“…Demodex spp. has been diagnosed in patients with diabetes, renal failure, and in patients undergoing haemodialysis [3,25,28,30].…”

Section: Epidemiologymentioning

confidence: 99%

Blepharitis and Demodex spp. infection

et al. 2017

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According to the latest reports Demodex mites appear to play an important role in the pathogenesis of chronic blepharitis. Demodex mites are cosmopolitan and are present in many species of mammals. In this paper we describe two species that are found in humans: Demodex folliculorum and D. brevis. Infection occurs during direct contact with an affected person and also through contact with dust containing eggs of the parasite, through contact with bed linen, as well as cosmetics used together with an affected person. Treatment of chronic blepharitis caused by D. folliculorum and D. brevis is difficult and time consuming. Some improvement can be achieved after topical application of yellow mercury ointment, sulphuric ointment, camphor oil, crotamiton, cholinesterase inhibitors, sulfacetamide, steroids, antibiotics and antifungal drugs. Good results have been achieved with oral ivermectin and permethrin cream. However, the best results were observed after treatment with metronidazole.

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“…Other studied links between DM2 and hair follicles include reports of Demodex folliculorum infestation in DM2 patients that can affect some hair characteristics (57). Arrector pili muscle fat degeneration in DM2 patients has also been described to be involved in hair loss (58, 59).…”

Section: Evaluation Of the Hypothesismentioning

confidence: 99%

Hair follicle characteristics as early marker of Type 2 Diabetes

et al. 2016

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Type 2 Diabetes mellitus (DM2) includes a continuum of metabolic disorders characterized by hyperglycemia that causes several chronic long-term complications such as coronary artery disease, peripheral arterial disease, nephropathy, and neuropathy. The hair follicle could reveal signs of early vascular impairment, yet its relationship to early metabolic injuries has been largely ignored. We propose that in earlier stages of the continuum of DM2-related metabolic disorders, a group of susceptible patients who do not yet meet the diagnostic criteria to be considered as persons with DM2 may present chronic vascular impairment and end organ damage, including hair follicle damage, which can be evaluated to identify an early risk marker. This hypothesis is based in the association found between insulin resistance and alopecia in non-diabetic persons, and the hair loss on the lower limbs as a manifestation of long-term peripheral arterial disease among subjects with DM2. In order to test this hypothesis, studies are required to evaluate if hair follicle characteristics are related to and can predict hyperglycemic complications, and if they do so, which feature of the hair follicle, such as hair growth, best characterizes such DM2-related conditions. If this hypothesis were proven to be true, significant advances towards a personalized approach for early prevention strategies and management of DM2 would be made. By focusing on the hair follicles, early stages of metabolic-related organ damage could be identified using non-invasive low-cost techniques. In so doing, this approach could provide early identification of DM2-susceptible individuals and lead to the early initiation of adequate primary prevention strategies to reduce or avoid the onset of large internal organ damage.

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The effect of blood glucose regulation on the presence of opportunistic Demodex folliculorum mites in patients with type 2 diabetes mellitus

Abstract: These current findings suggest that poor blood glucose regulation increases the susceptibility to D. folliculorum mite infestation in patients with type 2 diabetes.

Cited by 36 publications

References 30 publications

Demodex Parazytes in Schizophrenia

Demodex Parazytes in Schizophrenia

Blepharitis and Demodex spp. infection

Hair follicle characteristics as early marker of Type 2 Diabetes

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