The effect of blending poly (l-lactic acid) on in vivo performance of 3D-printed poly(l-lactide-co-caprolactone)/PLLA scaffolds

Duan, Ruiping; Wang, Yimeng; Su, Danning; Wang, Ziqiang; Zhang, Yiyun; Du, Bo; Liu, Lingrong; Li, Xuemin; Zhang, Qiqing

doi:10.1016/j.bioadv.2022.212948

Cited by 10 publications

(6 citation statements)

References 51 publications

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“…When comparing histological images of the F2 and F1 formulations, the only apparent difference appears to be the presence of the capsule (Figure 8A,B) and a slight increase in the number of inflammatory cells (Figures 7C and 8C). This finding of the presence of a capsule surrounding the implanted material is similar to that reported by other authors who, for the same 60-day period, describe the existence of a capsule around PLA and PCL composites [68,69].…”

Section: Biocompatibility Of Formulation F3supporting

confidence: 92%

Biocompatibility Assessment of Polycaprolactone/Polylactic Acid/Zinc Oxide Nanoparticle Composites under In Vivo Conditions for Biomedical Applications

Castro,

Araujo-Rodríguez,

Valencia-Llano

et al. 2023

Pharmaceutics

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The increasing demand for non-invasive biocompatible materials in biomedical applications, driven by accidents and diseases like cancer, has led to the development of sustainable biomaterials. Here, we report the synthesis of four block formulations using polycaprolactone (PCL), polylactic acid (PLA), and zinc oxide nanoparticles (ZnO-NPs) for subdermal tissue regeneration. Characterization by Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) confirmed the composition of the composites. Additionally, the interaction of ZnO-NPs mainly occurred with the C=O groups of PCL occurring at 1724 cm−1, which disappears for F4, as evidenced in the FT-IR analysis. Likewise, this interaction evidenced the decrease in the crystallinity of the composites as they act as crosslinking points between the polymer backbones, inducing gaps between them and weakening the strength of the intermolecular bonds. Thermogravimetric (TGA) and differential scanning calorimetry (DSC) analyses confirmed that the ZnO-NPs bind to the carbonyl groups of the polymer, acting as weak points in the polymer backbone from where the different fragmentations occur. Scanning electron microscopy (SEM) showed that the increase in ZnO-NPs facilitated a more compact surface due to the excellent dispersion and homogeneous accumulation between the polymeric chains, facilitating this morphology. The in vivo studies using the nanocomposites demonstrated the degradation/resorption of the blocks in a ZnO-NP-dependant mode. After degradation, collagen fibers (Type I), blood vessels, and inflammatory cells continue the resorption of the implanted material. The results reported here demonstrate the relevance and potential impact of the ZnO-NP-based scaffolds in soft tissue regeneration.

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Section: Biocompatibility Of Formulation F3supporting

confidence: 92%

Biocompatibility Assessment of Polycaprolactone/Polylactic Acid/Zinc Oxide Nanoparticle Composites under In Vivo Conditions for Biomedical Applications

Castro,

Araujo-Rodríguez,

Valencia-Llano

et al. 2023

Pharmaceutics

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“…[61][62][63][64]68,69,71,72 Various methods, such as surface treatment, chemical crosslinking, and blending with other materials can modify the mechanical properties, hydrophobicity, and degradation time of PLLA, making it one of the most promising candidates materials for both skeleton and fabric of bioabsorbable cardiac occluders. 143,155,[158][159][160][161] PDLLA is a copolymer composed of D-and L-lactic units its physical and biological properties can be adjusted by altering the proportions of L-and D-isomers. [162][163][164][165] Compared with PLLA, it has better flexibility, stretchability, and a faster degradation rate due to its irregular and completely amorphous structure.…”

Section: Poly-ε-caprolactonementioning

confidence: 99%

“…Nevertheless, when used as the fabric component for Absnow and modified Amplazter occluders, it demonstrated a satisfactory endothelialization process and tolerable inflammatory response, proving its feasibility as a fabric material 61–64,68,69,71,72 . Various methods, such as surface treatment, chemical crosslinking, and blending with other materials can modify the mechanical properties, hydrophobicity, and degradation time of PLLA, making it one of the most promising candidates materials for both skeleton and fabric of bioabsorbable cardiac occluders 143,155,158–161 …”

Section: Application Of Biodegradable Polymers In Absorbable Cardiac ...mentioning

confidence: 99%

Progress of biodegradable polymer application in cardiac occluders

Xu,

Fa,

Yang

et al. 2023

J Biomed Mater Res

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Cardiac septal defect is the most prevalent congenital heart disease and is typically treated with open‐heart surgery under cardiopulmonary bypass. Since the 1990s, with the advancement of interventional techniques and minimally invasive transthoracic closure techniques, cardiac occluder implantation represented by the Amplazter products has been the preferred treatment option. Currently, most occlusion devices used in clinical settings are primarily composed of Nitinol as the skeleton. Nevertheless, long‐term follow‐up studies have revealed various complications related to metal skeletons, including hemolysis, thrombus, metal allergy, cardiac erosion, and even severe atrioventricular block. Thus, occlusion devices made of biodegradable materials have become the focus of research. Over the past two decades, several bioabsorbable cardiac occluders for ventricular septal defect and atrial septal defect have been designed and trialed on animals or humans. This review summarizes the research progress of bioabsorbable cardiac occluders, the advantages and disadvantages of different biodegradable polymers used to fabricate occluders, and discusses future research directions concerning the structures and materials of bioabsorbable cardiac occluders.

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“…In the case of relatively delicate structures, such as scaffolds measuring 1-2 mm in thickness, one can enhance the presence of oxygen by permitting the gentle movement of fluid carrying dissolved oxygen to permeate through the interconnecting pores of said scaffold. However, the development of porous scaffolds may potentially compromise their mechanical strength, particularly in scenarios where stiff or rigid scaffolds are necessary (Duan et al, 2022). This obstacle can greatly hinder the advancement of bone-engineered constructs from the laboratory to practical applications in healthcare.…”

Section: Introductionmentioning

confidence: 99%

Oxygen generating biomaterials at the forefront of regenerative medicine: advances in bone regeneration

Zhao,

Zhou,

Xiao

et al. 2024

Front. Bioeng. Biotechnol.

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Globally, an annual count of more than two million bone transplants is conducted, with conventional treatments, including metallic implants and bone grafts, exhibiting certain limitations. In recent years, there have been significant advancements in the field of bone regeneration. Oxygen tension regulates cellular behavior, which in turn affects tissue regeneration through metabolic programming. Biomaterials with oxygen release capabilities enhance therapeutic effectiveness and reduce tissue damage from hypoxia. However, precise control over oxygen release is a significant technical challenge, despite its potential to support cellular viability and differentiation. The matrices often used to repair large-size bone defects do not supply enough oxygen to the stem cells being used in the regeneration process. Hypoxia-induced necrosis primarily occurs in the central regions of large matrices due to inadequate provision of oxygen and nutrients by the surrounding vasculature of the host tissues. Oxygen generating biomaterials (OGBs) are becoming increasingly significant in enhancing our capacity to facilitate the bone regeneration, thereby addressing the challenges posed by hypoxia or inadequate vascularization. Herein, we discussed the key role of oxygen in bone regeneration, various oxygen source materials and their mechanism of oxygen release, the fabrication techniques employed for oxygen-releasing matrices, and novel emerging approaches for oxygen delivery that hold promise for their potential application in the field of bone regeneration.

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The effect of blending poly (l-lactic acid) on in vivo performance of 3D-printed poly(l-lactide-co-caprolactone)/PLLA scaffolds

Cited by 10 publications

References 51 publications

Biocompatibility Assessment of Polycaprolactone/Polylactic Acid/Zinc Oxide Nanoparticle Composites under In Vivo Conditions for Biomedical Applications

Biocompatibility Assessment of Polycaprolactone/Polylactic Acid/Zinc Oxide Nanoparticle Composites under In Vivo Conditions for Biomedical Applications

Progress of biodegradable polymer application in cardiac occluders

Oxygen generating biomaterials at the forefront of regenerative medicine: advances in bone regeneration

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