The effect of black seed (Nigella sativa) extract on lipid metabolism in HepG2 cells

Haas, Michael J.; Naem, Emad; Almdallaleh, Sultan; Mooradian, Arshag D.

doi:10.1016/j.bbalip.2022.159155

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…There are several bioactive compounds present in NS, including thymoquinone (TQ), thymohydroquinone and dithymoquinone, which have anti-inflammatory and antioxidant properties and contribute to NS various pharmacological potentials [ 24 ]. These compounds target multiple signalling pathways involved in adipogenesis [ 44 ], lipid metabolism [ 45 ] and appetite regulation [ 46 ], making NS a potential alternative intervention for obesity.…”

Section: Introductionmentioning

confidence: 99%

A Review of the Potential Health Benefits of Nigella sativa on Obesity and Its Associated Complications

Adam,

Abu,

Kamal

et al. 2023

Plants

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Obesity has become a worldwide epidemic and its prevalence continues to increase at an alarming rate. It is considered a major risk factor for the development of several comorbidities, including type 2 diabetes, stroke, other cardiovascular diseases and even cancer. Conventional treatments for obesity, such as dietary interventions, exercise and pharmacotherapy, have proven to have limited effectiveness and are often associated with undesirable side effects. Therefore, there is a growing interest in exploring alternative therapeutic approaches. Nigella sativa (NS), a medicinal plant with multiple pharmacological properties, has gained attention due to its potential role in the treatment of obesity and its associated complications. The aim of this review is therefore to assess the effects of NS on obesity and its complications and to provide insights into the underlying mechanisms. From this review, NS appears to play a complementary or supportive role in the treatment of obesity and its complications. However, future studies are needed to verify the efficacy of NS in the treatment of obesity and its complications and to prove its safety so that it can be introduced in patients with obesity.

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Section: Introductionmentioning

confidence: 99%

A Review of the Potential Health Benefits of Nigella sativa on Obesity and Its Associated Complications

Adam,

Abu,

Kamal

et al. 2023

Plants

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Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Hosseini,

Ghavidel,

Aliyari

et al. 2024

CPB

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Background: Several studies have shown that the intake of N. sativa has a beneficial effect on metabolic syndrome and related disorders. In this meta-analysis, our primary objective was to assess the impact of Nigella sativa consumption on inflammation and oxidative stress biomarkers among individuals diagnosed with metabolic syndrome and its associated conditions. Methods: Our search was conducted on prominent online databases such as Web of Science, Scopus, PubMed, and EMBASE, utilizing relevant keywords until August 2023. Results: This meta-analysis was performed on 16 RCTs comprising 1033 participants. Our results showed that intake of nigella sativa significantly decreased CRP [SMD: -0.60; (95% CI: from -0.96 to -0.23); P = 0.00], TNF-α [SMD: -0.53; (95% CI: from -0.74 to -0.53); P = 0.00]; IL-6 [SMD: -0.54 ; (95% CI: from -1.01 to -0.07); P = 0.02], and MDA: [SMD: -1.28; (95% CI: from -2.11 to -0.46); P = 0.00] levels. In addition, SOD: [SMD: 1.35; (95% CI, from 0.77 to 1.93); P = 0.00] and TAC [SMD: 2.82; (95% CI, from 0.55 to 5.084); P = 0.01] levels significantly increased in the intervention group compared to the placebo group. Conclusion: Our results showed that THE consumption of N. sativa could be associated with improved oxidative stress and inflammation in patients with metabolic syndrome and related disorders.

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The effect of black seed (Nigella sativa) extract on lipid metabolism in HepG2 cells

Cited by 2 publications

References 42 publications

A Review of the Potential Health Benefits of Nigella sativa on Obesity and Its Associated Complications

A Review of the Potential Health Benefits of Nigella sativa on Obesity and Its Associated Complications

Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials

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