The effect of bismuth nanoparticles in kilovoltage and megavoltage radiation therapy using magnetic resonance imaging polymer gel dosimetry

Farahani, Saeid; Alam, Nader Riahi; Haghgoo, Soheila; Shirazi, Alireza; Geraily, Ghazale; Gorji, E; Kavousi, Nasibeh

doi:10.1016/j.radphyschem.2019.108573

Cited by 17 publications

(10 citation statements)

References 37 publications

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“…Overall, the DEF reported in this study in the presence of sheet and spherical Bi 2 O 3 NPs was more than other studies 37,45,52,53 . This supports the hypothesis that by decreasing energy up to 50 kV range in the IORT, the photoelectric effect could be amplified.…”

Section: Discussionsupporting

confidence: 87%

“…In contrast, given the direct contact of the applicator with the tumor in IORT, the data obtained in this study can have clinical applications. In addition, DEFs obtained in this study are significantly higher than those reported in previous studies in MV and kV energies with bismuth compound NPs 37,45,52,53 and about 90% higher than the DEF of the same spherical nanoparticles irradiated by 6 MV external radiotherapy which yielded a DEF of 1.31 41…”

Section: Discussioncontrasting

confidence: 73%

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Bismuth oxide nanoparticles as agents of radiation dose enhancement in intraoperative radiotherapy

et al. 2021

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Purpose Intraoperative radiotherapy (IORT) technique is an advanced radio therapeutic method used for delivery of a single high‐dose radiation during surgery while removing healthy tissues from the radiation field. Nowadays, growing attention is being paid to IORT for its low‐energy (kilovoltage) delivery as it requires less radiation protection, but suffers several disadvantages, including high‐dose delivery and prolonged treatment time. The application of nanoparticles with high atomic number and high attenuation coefficients in kilovoltage energy may help overcome the mentioned shortcomings. This study was designed to investigate and quantify the mean dose enhancement factor (DEF) in the presence of nanoparticles using IORT method. Methods Bismuth oxide nanoparticles (Bi2O3NPs), both in sheet and spherical formats, were synthesized using a novel hydrothermal method and characterized with x‐ray diffraction (XRD), transmission electron microscopy (TEM), and Brunauer–Emmett–Teller (BET) analysis. Genipin‐gelatin gel dosimeter (GENIPIN) was produced in three batches of pure with sheet and with spherical nanoparticles in concentration of 46.596 µg/ml, and irradiated with 50 kV x‐rays. Results Samples were scanned by a spectrophotometer, which indicated a DEF of 3.28 ± 0.37 and 2.50 ± 0.23 for sheet and spherical NPs, respectively. According to the results of this study, GENIPIN is a suitable dosimeter for the evaluation of three‐dimensional dose distribution in the presence Bi2O3 NPs. Conclusion As a result, IORT along with Bi2O3 NPs has the potential to reduce treatment time and/or normal tissue dose; moreover, it could provide localized dose enhancement.

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Section: Discussionsupporting

confidence: 87%

Section: Discussioncontrasting

confidence: 73%

Bismuth oxide nanoparticles as agents of radiation dose enhancement in intraoperative radiotherapy

et al. 2021

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“…Recently, addition of high atomic elements (such as bismuth, gadolinium, silver or gold nanoparticles, etc.) has been investigated for increasing photon sensitivity [80][81][82][83][84][85][86][87][88][89][90][91][92].…”

Section: Characterization and Performancementioning

confidence: 99%

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

Marrale

D’Errico

2021

Gels

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Radiation-sensitive gels are among the most recent and promising developments for radiation therapy (RT) dosimetry. RT dosimetry has the twofold goal of ensuring the quality of the treatment and the radiation protection of the patient. Benchmark dosimetry for acceptance testing and commissioning of RT systems is still based on ionization chambers. However, even the smallest chambers cannot resolve the steep dose gradients of up to 30–50% per mm generated with the most advanced techniques. While a multitude of systems based, e.g., on luminescence, silicon diodes and radiochromic materials have been developed, they do not allow the truly continuous 3D dose measurements offered by radiation-sensitive gels. The gels are tissue equivalent, so they also serve as phantoms, and their response is largely independent of radiation quality and dose rate. Some of them are infused with ferrous sulfate and rely on the radiation-induced oxidation of ferrous ions to ferric ions (Fricke-gels). Other formulations consist of monomers dispersed in a gelatinous medium (Polyacrylamide gels) and rely on radiation-induced polymerization, which creates a stable polymer structure. In both gel types, irradiation causes changes in proton relaxation rates that are proportional to locally absorbed dose and can be imaged using magnetic resonance imaging (MRI). Changes in color and/or opacification of the gels also occur upon irradiation, allowing the use of optical tomography techniques. In this work, we review both Fricke and polyacrylamide gels with emphasis on their chemical and physical properties and on their applications for radiation dosimetry.

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“…This bismuth oxide material combined with radiation and doxorubicin showed a remarkable synergistic ability for tumor elimination ability. Farahani et al [ 83 ] combined the bismuth nanoparticles with polymer gel dosimetry technique testing their effect in kilovolt and Megavolt radiation therapy proving the strong energy dependence of dose enhancement.…”

Section: Bismuth Oxide and Related Materials For Biological Applicmentioning

confidence: 99%

A Short Review on Biomedical Applications of Nanostructured Bismuth Oxide and Related Nanomaterials

2020

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In this review, we reported the main achievements reached by using bismuth oxides and related materials for biological applications. We overviewed the complex chemical behavior of bismuth during the transformation of its compounds to oxide and bismuth oxide phase transitions. Afterward, we summarized the more relevant studies regrouped into three categories based on the use of bismuth species: (i) active drugs, (ii) diagnostic and (iii) theragnostic. We hope to provide a complete overview of the great potential of bismuth oxides in biological environments.

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The effect of bismuth nanoparticles in kilovoltage and megavoltage radiation therapy using magnetic resonance imaging polymer gel dosimetry

Cited by 17 publications

References 37 publications

Bismuth oxide nanoparticles as agents of radiation dose enhancement in intraoperative radiotherapy

Bismuth oxide nanoparticles as agents of radiation dose enhancement in intraoperative radiotherapy

Hydrogels for Three-Dimensional Ionizing-Radiation Dosimetry

A Short Review on Biomedical Applications of Nanostructured Bismuth Oxide and Related Nanomaterials

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