The Effect of Bismuth Chloride on Some Blood and Biochemical Parameters in Male Laboratory Rats (Rattus-Rattus)

Abstract

The present study amid to characterized the potential toxic effects of bismuth chloride through oral administration on blood and biochiemical parameters of laboratory rats.Solutions of bismuth chloride were chronically feed by stomach tube to rats in(2.5mg/kg and 5 mg/kg).Animals were anesthetized after two months and blood samples were obtained,blood and biochemical parameters were appreciated between control and experimental Groups.The investigation of blood parameters included red blood cells count (RBC) hemoglobin concentration,packed cell volume PCV and total white blood cell count(WBC)biochemical parameters included total serum cholesterol(TSCH),alanin aminotransferase (ALT) and aspartate aminotransferase(AST).The results showed significant decrease (p≤0.05) of R.B.C count ,Hb concentrations PCV value and total W.B.C count in contrast ,there was significant increase(p≤0.05) of the total serum cholesterol(,ALTand AST) activities.