The effect of Biolex-MB40 on the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in lambs

Wójcik, Roman

doi:10.2478/pjvs-2014-0039

Cited by 10 publications

(12 citation statements)

References 35 publications

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“…These results were confirmed in another in vivo investigation in rats with cyclophosphamide suppressed immune systems [27]. Under these conditions, feeding β-glucans led to an increased phagocytic activity of monocytes and granulocytes.…”

Section: Studies Performed With the Proprietary Yeast β-Glucan Preparsupporting

confidence: 67%

Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan

Stier

Ebbeskotte

Gruenwald

2014

Nutr J

201

129

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Beta-glucans are a heterogeneous group of natural polysaccharides mostly investigated for their immunological effects. Due to the low systemic availability of oral preparations, it has been thought that only parenterally applied beta-glucans can modulate the immune system. However, several in vivo and in vitro investigations have revealed that orally applied beta-glucans also exert such effects. Various receptor interactions, explaining possible mode of actions, have been detected. The effects mainly depend on the source and structure of the beta-glucans. In the meantime, several human clinical trials with dietary insoluble yeast beta-glucans have been performed. The results confirm the previous findings of in vivo studies. The results of all studies taken together clearly indicate that oral intake of insoluble yeast beta-glucans is safe and has an immune strengthening effect.

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Section: Studies Performed With the Proprietary Yeast β-Glucan Preparsupporting

confidence: 67%

Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan

Stier

Ebbeskotte

Gruenwald

2014

Nutr J

201

129

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“…This in turn is suggested to trigger the innate and adaptive immune response. Indeed, orally administered yeast beta-glucans induced the innate immunity as shown by a higher phagocytic activity and oxidative metabolism of immune cells in rats [ 17 ]. The positive effect of yeast beta-glucan administration on the specific humoral and cellular immunity was further demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body’s defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects

et al. 2013

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PurposeThe effect of brewers’ yeast (1,3)-(1,6)-beta-d-glucan consumption on the number of common cold episodes in healthy subject was investigated.MethodsIn a placebo-controlled, double-blind, randomized, multicentric clinical trial, 162 healthy participants with recurring infections received 900 mg of either placebo (n = 81) or an insoluble yeast (1,3)-(1,6)-beta-d-glucan preparation (n = 81) per day over a course of 16 weeks. Subjects were instructed to document each occurring common cold episode in a diary and to rate ten predefined infection symptoms during an infections period, resulting in a symptom score. The subjects were examined by the investigator during the episode visit on the 5th day of each cold episode.ResultsIn the per protocol population, supplementation with insoluble yeast (1,3)-(1,6)-beta-glucan reduced the number of symptomatic common cold infections by 25 % as compared to placebo (p = 0.041). The mean symptom score was 15 % lower in the beta-glucan as opposed to the placebo group (p = 0.125). Beta-glucan significantly reduced sleep difficulties caused by cold episode as compared to placebo (p = 0.028). Efficacy of yeast beta-glucan was rated better than the placebo both by physicians (p = 0.004) participants (p = 0.012).ConclusionThe present study demonstrated that yeast beta-glucan preparation increased the body’s potential to defend against invading pathogens.

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“…In this study, the insoluble (1,3)-(1,6)--glucan made from brewers' yeast (Saccharomyces cerevisiae: Yestimun ® , previously called Biolex Beta-HP), was used. The positive effects of this specific preparation on the immune system have been confirmed in various in vitro studies [11][12][13]. Herein the common cold was used as a model system to show that the insoluble beta-glucan preparation activates the human defense system against various pathogens.…”

Section: Introductionmentioning

confidence: 93%

A Double-Blind, Randomized, Placebo-Controlled Nutritional Study Using an Insoluble Yeast Beta-Glucan to Improve the Immune Defense System

Graubaum¹,

Busch²,

Stier³

et al. 2012

FNS

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Purpose: In a placebo-controlled, double-blind, randomized clinical trial, the effect of an insoluble yeast beta-glucan preparation on the incidences of common colds and its effect on common cold symptoms were compared to placebo. Methods: 100 healthy participants with recurring infections were randomly assigned to receive either placebo or yeast beta-glucan (Yestimun®; n = 50 each group) over a period of 26 weeks. The subjects had to document each common cold episode in a diary, and rate 6 predefined infections symptoms on a 3-point rating scale during an infection period, resulting in an infection score. The common cold episodes were confirmed by the investigators. Results: A total of 171 common cold episodes were documented. Of these, 76 were experienced by 38 subjects in the beta-glucan group and 96 were experienced by 48 subjects in the placebo group (p = 0.406). The beta-glucan group had significantly more subjects without incidences of common cold than the placebo group (15.6% vs 2.0%; p = 0.019). During the most intense infection season (first 13 weeks of the study), the beta-glucan group had significantly less infections compared to placebo (p = 0.02). Beta-glucan significantly reduced the typical cold symptoms (“sore throat and/or difficulty swallowing”, “hoarseness and/or cough” and “runny nose”) as opposed to placebo. Conclusion: The present study demonstrates a prophylactic effect of yeast beta-glucan on the occurrence of common colds as opposed to placebo. In addition, when these episodes occurred, they were from the beginning less pronounced and subsided faster

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The effect of Biolex-MB40 on the phagocytic activity and oxidative metabolism of peripheral blood granulocytes and monocytes in lambs

Cited by 10 publications

References 35 publications

Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan

Immune-modulatory effects of dietary Yeast Beta-1,3/1,6-D-glucan

Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body’s defence against pathogens: a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects

A Double-Blind, Randomized, Placebo-Controlled Nutritional Study Using an Insoluble Yeast Beta-Glucan to Improve the Immune Defense System

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