The effect of bioactive glass particle size and liquid phase on the physical-chemical and mechanical properties of carbonated apatite cement

Mabroum, Hanaa; Noukrati, Hassan; Youcef, Hicham Ben; Oudadesse, Hassane; Barroug, Allal

doi:10.1016/j.ceramint.2022.06.126

Cited by 4 publications

(4 citation statements)

References 42 publications

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“…The fine BG particles agglomerate and absorb more water; this increases the friction between them. The setting time of formulated cement also increases significantly with a decrease in BG particle size, as the cohesion in the cement paste weakens (Hasan et al, 2019;Mabroum et al, 2022). Frontiers in Bioengineering and Biotechnology frontiersin.org…”

Section: Bioglassmentioning

confidence: 99%

Advances in materials used for minimally invasive treatment of vertebral compression fractures

Sui,

Yu,

Sun

et al. 2023

Front. Bioeng. Biotechnol.

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Vertebral compression fractures are becoming increasingly common with aging of the population; minimally invasive materials play an essential role in treating these fractures. However, the unacceptable processing-performance relationships of materials and their poor osteoinductive performance have limited their clinical application. In this review, we describe the advances in materials used for minimally invasive treatment of vertebral compression fractures and enumerate the types of bone cement commonly used in current practice. We also discuss the limitations of the materials themselves, and summarize the approaches for improving the characteristics of bone cement. Finally, we review the types and clinical efficacy of new vertebral implants. This review may provide valuable insights into newer strategies and methods for future research; it may also improve understanding on the application of minimally invasive materials for the treatment of vertebral compression fractures.

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Section: Bioglassmentioning

confidence: 99%

Advances in materials used for minimally invasive treatment of vertebral compression fractures

Sui,

Yu,

Sun

et al. 2023

Front. Bioeng. Biotechnol.

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“…Several authors have claimed the effect of some organic molecules on the formation of apatite and brushite cements. Mabroum et al, discussed the effect of alginate on the formation of apatite phase and suggested that the delaying effect of this polymer on the precipitation and formation of apatite could be due to the formation of calcium alginate because of the presence of the COO-group resulting in the ionic exchange of Na and Ca (Mabroum et al, 2022(Mabroum et al, , 2021. Alkhraisat et al, reported that low concentrations of tetracyclines can produce calcium chelates that affected primary nucleation, which interfered with mineral precipitation, resulting in a delay effect in the setting reaction for both apatite (Ratier et al, 2004(Ratier et al, , 2001) and brushite cements (Alkhraisat et al, 2010).…”

Section: Effect Of Ciprofloxacin and Its Content On The Setting Prope...mentioning

confidence: 99%

Design of antibacterial apatitic composite cement loaded with Ciprofloxacin: Investigations on the physicochemical Properties, release Kinetics, and antibacterial activity

Mabroum

Baza

Youcef

et al. 2023

International Journal of Pharmaceutics

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“…Although the combined use of CPC and drug-impregnated mMBG can control drug release, improve biocompatibility, promote bone growth, and address the limitations of their respective applications, it also affects the physicochemistry, microstructure, injectability, hardening properties, and mechanical strength [ 17 , 18 ]. Although MBG/CPC bone cements have been studied before, the exact composition can vary due to the different properties of CPC bone cements, and the drug loading can be considered as different [ 16 , 17 , 18 , 19 ]. Therefore, the purpose of this study was to prepare different ratios of gentamicin-impregnated mMBG and composite them into CPCs to develop an mMBG/CPC bone cement.…”

Section: Introductionmentioning

confidence: 99%

Injectability, Processability, Drug Loading, and Antibacterial Activity of Gentamicin-Impregnated Mesoporous Bioactive Glass Composite Calcium Phosphate Bone Cement In Vitro

Chu

Huang

et al. 2022

Biomimetics

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Calcium phosphate cement (CPC) is similar to bone in composition and has plasticity, while mesoporous bioactive glass (MBG) has the advantage of releasing Si, which can promote osteogenic properties and drug loading capacity. A sol–gel-prepared MBG micro-powder (mMBG) and further impregnated antibiotic gentamicin sulfate (Genta@mMBG: 2, 3, and 4 mg/mL) antibiotic were added to CPC at different weight ratios (5, 10, and 15 wt.%) to study CPC’s potential clinical applications. Different ratios of mMBG/CPC composite bone cement showed good injectability and disintegration resistance, but with increasing mMBG addition, the working/setting time and compressive strength decreased. The maximum additive amount was 10 wt.% mMBG due to the working time of ~ 5 min, the setting time of ~ 10 min, and the compressive strength of ~51 MPa, indicating that it was more suitable for clinical surgical applications than the other groups. The 2Genta@mMBG group loaded with 2 mg/mL gentamicin had good antibacterial activity, and the 10 wt.% 2Genta@mMBG/CPC composite bone cement still had good antibacterial activity but reduced the initial release of Genta. 2Genta@mMBG was found to have slight cytotoxicity, so 2Genta@mMBG was composited into CPC to improve the biocompatibility and to endow CPC with more advantages for clinical application.

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The effect of bioactive glass particle size and liquid phase on the physical-chemical and mechanical properties of carbonated apatite cement

Cited by 4 publications

References 42 publications

Advances in materials used for minimally invasive treatment of vertebral compression fractures

Advances in materials used for minimally invasive treatment of vertebral compression fractures

Design of antibacterial apatitic composite cement loaded with Ciprofloxacin: Investigations on the physicochemical Properties, release Kinetics, and antibacterial activity

Injectability, Processability, Drug Loading, and Antibacterial Activity of Gentamicin-Impregnated Mesoporous Bioactive Glass Composite Calcium Phosphate Bone Cement In Vitro

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