The Effect of Biliary Bile Acid Concentration and Composition on the Calcium Level in Human Gallbladder Bile.

Tamasawa, Naoki; Yoneda, Masashi; Makino, Isao; Takebe, Kazuo; Sone, Ken; Kogawa, Rikio

doi:10.1620/tjem.171.297

Tohoku J. Exp. Med.

1993

DOI: 10.1620/tjem.171.297

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The Effect of Biliary Bile Acid Concentration and Composition on the Calcium Level in Human Gallbladder Bile.

Naoki Tamasawa

Masashi Yoneda

Isao Makino

et al.

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2024

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Cited by 3 publications

(1 citation statement)

References 28 publications

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“…Although such a cholelithogenic effect cannot be ruled out, it could possibly be mediated by an effect on bile calcium transport by PTH itself. This is of interest since the transport of calcium in bile is known to be an active process [2] and bile calcium concentration can greatly exceed that in serum [8].…”

mentioning

confidence: 99%

Reply to correspondence letter by Jae Il Shin and Jae Seung Lee: Bartter syndrome and cholelithiasis in an infant: is this a mere coincidence?

Robitaille

2008

Eur J Pediatr

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mentioning

confidence: 99%

Reply to correspondence letter by Jae Il Shin and Jae Seung Lee: Bartter syndrome and cholelithiasis in an infant: is this a mere coincidence?

Robitaille

2008

Eur J Pediatr

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Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

Wang

Cheung

et al. 2023

Sci. China Life Sci.

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Methylation changes of liver DNA during the formation of gallstones

Peng,

Li,

Tong

et al. 2024

Epigenomics

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Aim: To explore the overall methylation changes in liver tissues during the formation of gallstones, as well as the key pathways and genes involved in the process. Methods: Reduced-representation bisulfite sequencing and RNA sequencing were conducted on the liver tissues of mice with gallstones and control normal mice. Results: A total of 8705 differentially methylated regions in CpG and 1410 differentially expressed genes were identified. The joint analysis indicated that aberrant DNA methylation may be associated with dysregulated gene expression in key pathways such as cholesterol metabolism and bile secretion. Conclusion: We propose for the first time that methylation changes in some key pathway genes in liver tissue may be involved in the formation of gallstones.

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The Effect of Biliary Bile Acid Concentration and Composition on the Calcium Level in Human Gallbladder Bile.

Cited by 3 publications

References 28 publications

Reply to correspondence letter by Jae Il Shin and Jae Seung Lee: Bartter syndrome and cholelithiasis in an infant: is this a mere coincidence?

Reply to correspondence letter by Jae Il Shin and Jae Seung Lee: Bartter syndrome and cholelithiasis in an infant: is this a mere coincidence?

Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

Methylation changes of liver DNA during the formation of gallstones

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