The Effect of Beta-Trace Protein on Diagnosis and Prognosis in Patients with Acute Coronary Syndrome

Sert, Ekrem Taha; Akıllı, Nazire Belgin; Köylü, Ramazan; Cander, Başar; Kokulu, Kâmil; Köylü, Öznur

doi:10.7759/cureus.7135

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…Criteria for NSTEMI patients were as follows: a) no ST-segment elevation as previously described and b) positive markers showing myocardial necrosis. Criteria for UAP were as follows: a) absence of 1 mm or more ST-segment elevation as defined, b) negative markers showing myocardial necrosis and the presence of angina pectoris in any of the following three features: 1) angina occurring at rest or over a long period of time (usually >20 min), new-onset angina of at least class III severity according to the Canadian Cardiovascular Society (CCS) classification, a recent progression of at least one CCS class in pain classification, or a new angina acceleration of at least CCS class III [14][15].…”

Section: Figure 1: Flow Diagram Of the Studymentioning

confidence: 99%

Effect of Serum Netrin-1 Levels on Diagnosis and Prognosis in Patients Admitted to the Emergency Service for Acute Coronary Syndrome

Mutlu

Akıllı

Cander

et al. 2020

Cureus

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Background Netrin-1 is a recently discovered diagnostic biomarker that indicates atherosclerosis, angiogenesis, and ischemia-reperfusion damage. There are no human studies about Netrin-1 in acute coronary syndrome (ACS). The purpose of the present study was to investigate Netrin-1 levels in the early diagnosis and successful reperfusion of ACS. Method The study was conducted with 188 patients diagnosed with ACS and 50 healthy subjects at the emergency unit in a prospective design. Blood samples were collected from the patient group at initial admission and after angiography. The control group consisted of healthy adult subjects without any disease. Netrin-1 levels were studied in both groups. Results The Netrin-1 levels of the patient group at the time of admission were found to be higher than of the control group (p<0.001). In the patient group, netrin-1 levels measured at initial admission (1.53±0.19) and after angiography (1.49±0.19) were determined to be statistically significant (p:0.049). In the patient group, where the Thrombolysis in Myocardial Infarction (TIMI) 3 flow was established after angiography, netrin-1 levels were detected to be low (p:0.039). Netrin-1 levels obtained at the time of admission were determined to be significantly different in the Global Registry of Acute Coronary Events (GRACE) moderate and high-risk groups in comparison to the low-risk group (p:0.017). Conclusion Netrin-1 was shown to increase in the early diagnosis of ACS and to decrease in patients for whom reperfusion was established after angiography. Therefore, Netrin-1 can be an important biomarker as an indicator of diagnosis and successful reperfusion in ACS.

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Section: Figure 1: Flow Diagram Of the Studymentioning

confidence: 99%

Effect of Serum Netrin-1 Levels on Diagnosis and Prognosis in Patients Admitted to the Emergency Service for Acute Coronary Syndrome

Mutlu

Akıllı

Cander

et al. 2020

Cureus

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“…A cohort study recruiting patients with atrial fibrillation and on chronic anticoagulation concluded that higher plasma BTP levels were correlated with increased risk for embolic events and overall death, independent of well-established risk variables included in the CHAD 2 DS 2 -VASc scoring system [27]. In contrast, in patients presenting acutely to the emergency healthcare system with a diagnosis of acute coronary syndrome, a serial checkup of serum BTP levels did not predict the poor prognosis [28].…”

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confidence: 99%

The Prognostic Role of Serum β-Trace Protein Levels among Patients on Maintenance Hemodialysis

Huang,

Hsu,

Wang

et al. 2024

Diagnostics

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Cardiovascular (CV) diseases are the most commonly encountered etiology of mortality in patients having kidney failure. β-Trace protein (BTP) is a biomarker of glomerular filtration function as well as a potential predictor of adverse CV outcomes. This study aimed to determine the prognostic value of BTP in patients on chronic hemodialysis (HD). A total of 96 patients undergoing HD were enrolled. Baseline variables were collected, and the patients were tracked for 3 years. Twenty-five patients died at 3 years. Those who experienced mortality were noted to have higher serum concentrations of BTP and a higher incidence of diabetes mellitus (DM). The area under the receiver operating characteristic curve for serum BTP distinguishing mortality from survival was 0.659 (95% confidence interval [CI], 0.555–0.752; p = 0.027). After the adjustment of variables potentially affecting survival rates, BTP levels above the median (adjusted hazard ratio [aHR]: 2.913, 95% CI, 1.256–6.754; p = 0.013), the presence of DM (aHR: 2.474, 95% CI, 1.041–5.875; p = 0.040), and low serum albumin (aHR: 0.298, 95% CI, 0.110–0.806; p = 0.017) independently correlated with survival in HD patients. Serum BTP is a novel biomarker for predicting overall outcomes in HD patients.

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The Effect of Beta-Trace Protein on Diagnosis and Prognosis in Patients with Acute Coronary Syndrome

Cited by 2 publications

References 18 publications

Effect of Serum Netrin-1 Levels on Diagnosis and Prognosis in Patients Admitted to the Emergency Service for Acute Coronary Syndrome

Effect of Serum Netrin-1 Levels on Diagnosis and Prognosis in Patients Admitted to the Emergency Service for Acute Coronary Syndrome

The Prognostic Role of Serum β-Trace Protein Levels among Patients on Maintenance Hemodialysis

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