The effect of berberine and geniposide on experimental colitis

Zhou, Haiyan; Mineshita, Satoru

doi:10.1016/s0016-5085(00)84457-1

Cited by 55 publications

(71 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although berberine has been used as an herbal medicine for treating diarrhea and bacterial and parasitic infections and has shown various beneficial effects on several diseases in animal models, including preventing TNBS-induced colitis (18,22,46,47), reducing cholesterol levels (21), improving glucose metabolism in diabetic rats (43), attenuating autoimmune encephalomyelitis (25), and enhancing progression of Type 1 diabetes (8), in vivo studies to investigate berberine's mechanisms of action in disease treatment are needed for its clinical application. The purpose of this work was to provide insights into understanding the treatment effects and mechanisms of berberine in intestinal inflammation in an animal model of colitis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice

Yan

Wang

Shi

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

157

131

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) results from dysregulation of intestinal mucosal immune responses to microflora in genetically susceptible hosts. A major challenge for IBD research is to develop new strategies for treating this disease. Berberine, an alkaloid derived from plants, is an alternative medicine for treating bacterial diarrhea and intestinal parasite infections. Recent studies suggest that berberine exerts several other beneficial effects, including inducing anti-inflammatory responses. This study determined the effect of berberine on treating dextran sulfate sodium (DSS)-induced intestinal injury and colitis in mice. Berberine was administered through gavage to mice with established DSS-induced intestinal injury and colitis. Clinical parameters, intestinal integrity, proinflammatory cytokine production, and signaling pathways in colonic macrophages and epithelial cells were determined. Berberine ameliorated DSS-induced body weight loss, myeloperoxidase activity, shortening of the colon, injury, and inflammation scores. DSS-upregulated proinflammatory cytokine levels in the colon, including TNF, IFN-γ, KC, and IL-17 were reduced by berberine. Berberine decreased DSS-induced disruption of barrier function and apoptosis in the colon epithelium. Furthermore, berberine inhibited proinflammatory cytokine production in colonic macrophages and epithelial cells in DSS-treated mice and promoted apoptosis of colonic macrophages. Activation of signaling pathways involved in stimulation of proinflammatory cytokine production, including MAPK and NF-κB, in colonic macrophages and epithelial cells from DSS-treated mice was decreased by berberine. In summary, berberine promotes recovery of DSS-induced colitis and exerts inhibitory effects on proinflammatory responses in colonic macrophages and epithelial cells. Thus berberine may represent a new therapeutic approach for treating gastrointestinal inflammatory disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

“…By using an IL-12-driven Th1 immune response-mediated colitis model, 2,6,4-trinitrobenzenesulfonic acid (TNBS)-induced colitis, berberine has been found to prevent colitis and decrease proinflammatory cytokine production in this model (18,22,46,47). However, treatment studies of established colitis are lacking.…”

mentioning

confidence: 99%

Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice

Yan

Wang

Shi

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

157

131

View full text Add to dashboard Cite

show abstract

“…They are mediators of the immuno-inflammatory response and could coordinate the cell interactions [11,35]. Berberine is also reported to have anti-inflammatory effects in vitro and in vivo [36][37][38]. The administration of neutral sulfate berberine significantly reduced plasma tumor necrosis factor-α, interferon-γ and nitric oxide levels in mice challenged with lipopolysaccharide [38].…”

Section: Discussionmentioning

confidence: 99%

Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage

Yao

Zheng

et al. 2009

Cell Res

View full text Add to dashboard Cite

show abstract

“…In this context, berberine has been shown to inhibit ion transport in human colonic epithelia and to decrease intestinal permeability (Kim et al, 2003). Beneficial effects of berberine on mucosa healing in TNB (trinitrobenzene sulfonic acid)-induced colitis in rats were assumed to be due to inhibition of IL-8 production (Zhou and Mineshita, 2000). However, the molecular background of these effects is unknown.…”

Section: Role Of Berberinementioning

confidence: 99%

TNFα-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFκB signaling

Amasheh

Fromm

Krug

et al. 2010

Journal of Cell Science

198

143

View full text Add to dashboard Cite

SummaryTNFa-mediated tight junction defects contribute to diarrhea in inflammatory bowel diseases (IBDs). In our study, the signaling pathways of the TNFa effect on barrier-or pore-forming claudins were analyzed in HT-29/B6 human colon monolayers. Berberine, a herbal therapeutic agent that has been recently established as a therapy for diabetes and hypercholesterinemia, was able to completely antagonize the TNFa-mediated barrier defects in the cell model and in rat colon. Ussing chamber experiments and two-path impedance spectroscopy revealed a decrease of paracellular resistance after TNFa to 11±4%, whereas transcellular resistance was unchanged. The permeability of the paracellular marker fluorescein was increased fourfold. Berberine alone had no effect while it fully prevented the TNFa-induced barrier defects. This effect on resistance was confirmed in rat colon. TNFa removed claudin-1 from the tight junction and increased claudin-2 expression. Berberine prevented TNFa-induced claudin-1 disassembly and upregulation of claudin-2. The effects of berberine were mimicked by genistein plus BAY11-7082, indicating that they are mediated via tyrosine kinase, pAkt and NFkB pathways. In conclusion, the anti-diarrheal effect of berberine is explained by a novel mechanism, suggesting a therapeutic approach against barrier breakdown in intestinal inflammation.

show abstract

The effect of berberine and geniposide on experimental colitis

Cited by 55 publications

References 0 publications

Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice

Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice

Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage

TNFα-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFκB signaling

Contact Info

Product

Resources

About