The effect of bearing surface on risk of periprosthetic joint infection in total hip arthroplasty

Hexter, Adam; Hislop, Simon; Blunn, Gordon; Liddle, Alexander D.

doi:10.1302/0301-620x.100b2.bjj-2017-0575.r1

Cited by 44 publications

(31 citation statements)

References 54 publications

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“…Periprosthetic joint infection (PJI) is the most common cause of knee arthroplasty failure which accounts for 16% to 25% of all failed knee replacements [1][2][3][4] and is the third most common indication for revision hip arthroplasty [5][6][7][8][9]. Our previous findings indicated that the expression level of synovial fluid (SF) interleukin-16 (IL-16) in patients with PJI was higher than that in patients with aseptic loosening [10].…”

Section: Introductionmentioning

confidence: 99%

Synovial Fluid Interleukin-16 Contributes to Osteoclast Activation and Bone Loss through the JNK/NFATc1 Signaling Cascade in Patients with Periprosthetic Joint Infection

Chang

Hsiao

et al. 2020

IJMS

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Because of lipopolysaccharide (LPS)-mediated effects on osteoclast differentiation and bone loss, periprosthetic joint infection (PJI) caused by Gram-negative bacteria increases the risk of aseptic loosening after reimplantation. Synovial fluid interleukin-16 (IL-16) expression was higher in patients with PJI than in patients without joint infection. Thus, we explored the effects of IL-16 on bone. We investigated whether IL-16 modulates osteoclast or osteoblast differentiation in vitro. An LPS-induced bone loss mice model was used to explore the possible advantages of IL-16 inhibition for the prevention of bone loss. IL-16 directly activated p38 and c-Jun N-terminal kinase (JNK)/mitogen-activated protein kinase (MAPK) signaling and increased osteoclast activation markers, including tartrate-resistant acid phosphatase (TRAP), cathepsin K, and nuclear factor of activated T cells 1 (NFATc1). IL-16 directly caused monocytes to differentiate into TRAP-positive osteoclast-like cells through NFATc1 activation dependent on JNK/MAPK signaling. Moreover, IL-16 did not alter alkaline phosphatase activity or calcium deposition during osteoblastic differentiation. Finally, IL-16 inhibition prevented LPS-induced trabecular bone loss and osteoclast activation in vivo. IL-16 directly increased osteoclast activation through the JNK/NFATc1 pathway. IL-16 inhibition could represent a new strategy for treating infection-associated bone loss.Int. J. Mol. Sci. 2020, 21, 2904 2 of 15 of differentiation 4 (CD4 + ) lymphocytes, monocytes, and eosinophils [11,12]. IL-16 is synthesized as a precursor protein (pro-IL-16) of approximately 68 kDa. Pro-IL-16 is cleaved by activated caspase-3 and then IL-16 generation [13]. CD4 serves as a signaling transducing receptor for IL-16 signaling. Increased intracytoplasmic calcium and inositol trisphosphate can be initiated when IL-16 interacts with CD4 receptors, and this subsequently activates stress-activated protein kinases (SAPKs) p46 and p54. Stimulation with IL-16 also activates members of the mitogen-activated protein kinase (MAPK) family, namely c-Jun N-terminal kinase (JNK) and p38 but does not activate extracellular signal-regulated kinase (ERK)-1 or ERK-2 [14]. IL-16 can activate monocytes and stimulate the secretion of inflammatory cytokines, chiefly tumor necrosis factor (TNF)-α, IL-1β, 15,16]. Currently, these cytokines are believed to promote the development of septic arthritis [17][18][19].PJI can result from Gram-positive (GP) or Gram-negative (GN) bacterial infections. Our previous retrospective study revealed that GN infections were associated with an increased risk of aseptic loosening as compared with GP infections [20]. The cell walls of GP bacteria contain lipoteichoic acid (LTA) components, whereas those of GN bacteria contain components of lipopolysaccharide (LPS). In studies of mice receiving intrafemoral injections of LPS or LTA, LPS reduced both the number of trabeculae and bone mineral density, whereas LTA did not have this effect [20]. In addition, disruption of the bal...

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Section: Introductionmentioning

confidence: 99%

Synovial Fluid Interleukin-16 Contributes to Osteoclast Activation and Bone Loss through the JNK/NFATc1 Signaling Cascade in Patients with Periprosthetic Joint Infection

Chang

Hsiao

et al. 2020

IJMS

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“…Data from the Australian Orthopaedic Association National Joint Replacement Registry showed a higher cumulative risk of revision for infection for metal-on-metal bearing surfaces (in particular, large-head metal-on-metal) compared with others at both the national and individual-surgeon level 73 . In a systematic review and meta-analysis, Hexter et al found no differences in the incidence of revision for infection when comparing metal-on-polyethylene, ceramic-on-polyethylene, and ceramic-on-ceramic articulations 74 .…”

Section: Risk Factorsmentioning

confidence: 99%

What’s New in Hip Replacement

Glassman

2018

The Journal of Bone and Joint Surgery

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“…It is all about material costs, the involvement of specialized and hyperspecialized human resources, but also the efforts of social reintegration of the affected patients, who frequently associate different degrees of depression. In the case of Orthopedics, but also of the other surgical specialties, infection of a wound leads to the slowing down of the healing process, accompanied by an increase of the psychological stress suffered by the patient [7,9,[10][11][12]. As such, patients describe pains of greater intensity as compared to those with the same pathology, who cured without infection.…”

Section: Introductionmentioning

confidence: 99%

“…There are numerous implicated microbial agents, of which, the following should be mentioned: Staphylococcus aureus (S. aureus), coagulase-negative staphylococci, Escherichia coli, Enterobacter spp., Klebsiella spp., Pseudomonas aeruginosa. Among these, S. aureus is the most frequently involved [7,8,[10][11][12]15,16].…”

Section: Introductionmentioning

confidence: 99%

Utility of microcalorimetry in describing the growth curve of C. albicans at different temperatures – indentifying the optimal growth temperature

Popa

Șerban

et al. 2019

Romanian Journal of Orthopaedic Surgery and Traumatology

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In comparison with other medical specialties, Orthopedics and Traumatology are continuously impressively developing, intrinsically connected to technological evolution. More than in other fields, in Orthopedics and Traumatology, the technological progress becomes obvious also by the frequent use of implants or osteosynthesis materials. By performing a simple search in the specialty literature, an exponential growth of arthroplasty surgeries in correlation with the life span of the population and implying a need that presupposes the increase of the quality of life, also by maintaining or improving mobility at a satisfying level, can be observed. At the same time, due to the increase in the number of traffic and sports accidents, the use of artificial joints and implants for osteosynthesis will constantly rise. The prostheses and the osteosynthesis materials used for the treatment of degenerative, traumatic or even esthetic pathologies are made of materials with a good biocompatibility. Candida albicans is an optional anaerobic microorganism so the experiments performed with different volumes of environment were most likely influenced by the amount of oxygen, nutrient. In the described research, we demonstrated that, using microcalorimetry, it is possible to identify this fungus in half the time required for classical microbiological identification. In addition, as our team has shown, there is the possibility of real-time antifungigram by using microcalorimetry.

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The effect of bearing surface on risk of periprosthetic joint infection in total hip arthroplasty

Cited by 44 publications

References 54 publications

Synovial Fluid Interleukin-16 Contributes to Osteoclast Activation and Bone Loss through the JNK/NFATc1 Signaling Cascade in Patients with Periprosthetic Joint Infection

Synovial Fluid Interleukin-16 Contributes to Osteoclast Activation and Bone Loss through the JNK/NFATc1 Signaling Cascade in Patients with Periprosthetic Joint Infection

What’s New in Hip Replacement

Utility of microcalorimetry in describing the growth curve of C. albicans at different temperatures – indentifying the optimal growth temperature

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