The effect of baseline serum luteinizing hormone levels on follicular development, ovulation, conception and pregnancy outcome in infertile patients with polycystic ovarian syndrome

Shanmugham, Deepa; Vidhyalakshmi, Ramadoss Kabilan; Shivamurthy, H M

doi:10.18203/2320-1770.ijrcog20175869

Cited by 8 publications

(11 citation statements)

References 14 publications

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“…In the present study, on laparoscopic evaluation, majority of the patients had polycystic ovaries (31.1%), followed by tubal pathology (11.1%) and endometriosis, since PCOS is the most common cause of infertility in recent years. 17 The findings of our study are comparable to various other studies. [9][10][11][12][18][19][20][21] The prospective study by Boricha et al, in 50 infertile couples found polycystic ovarian syndrome as the commonest cause of infertility in both primary and secondary infertility.…”

Section: Discussionsupporting

confidence: 92%

Role of diagnostic hystero-laparoscopy in the evaluation of female infertility

Shanmugham

Sahitya

Natarajan

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: Infertility affects about 10-15% of reproductive age couples. The main causes of infertility include male factor, ovulatory disorders, tubal factor and endometriosis. This study was conducted to determine the role of Diagnostic hystero-laparoscopy (DHL) in the evaluation of female infertility.Methods: This study was a prospective study done in a tertiary care centre over a period of 1 year on all infertile couples. The exclusion criteria: male factor infertility, hypothyroidism, hyperprolactinemia, acute pelvic inflammatory disease. Diagnostic hysterolaparoscopy was performed in all study patients in pre ovulatory phase, under general anaesthesia. The findings were then documented and analysed.Results: A total number of 90 patients were recruited for the study. The mean age of the patients was 28±3 years. The mean BMI of the study patients was 25±4 kg/m2. The mean duration of infertility was 5.4 years. On laparoscopy, 28 patients had polycystic ovaries (31.1%), 4 patients had pelvic adhesions (4.4%), 2 patients had endometriosis (2.2%) and tubal block was identified in 10 patients (11.11%). 10 patients had abnormal findings on hysteroscopy.Conclusions: Hystero laparoscopy is an effective diagnostic tool in the evaluation of infertility and has to be included in basic diagnostic workup.

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Section: Discussionsupporting

confidence: 92%

Role of diagnostic hystero-laparoscopy in the evaluation of female infertility

Shanmugham

Sahitya

Natarajan

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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“…31 The mean LH value in the study is 5.9 IU/L which is comparable to a study done by Shanmugam et al where the mean LH value is 5.6 IU/L. 32 The incidence of cardiometabolic risk factors increase in women with polycystic ovarian syndrome. 33…”

Section: Discussionsupporting

confidence: 71%

Clinical and hormonal profile of patients diagnosed with polycystic ovarian syndrome at tertiary care hospital in Tamil Nadu

Sathiya

Renuka

Famida

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: In recent years due to the changing sedentary life style, irregular periods and infertility has become a major concern. There are many causes for infertility out of which ovulatory disorders contribute to a great extend. The main objective of the study was to assess the clinical and hormonal profile of patients diagnosed with polycystic ovarian disease at tertiary care hospital in Tamil Nadu.Methods: This study was a cross sectional study and was carried out at the Department of Obstetrics and Gynaecology at a tertiary care hospital of Tamil Nadu. The study was done for a period of 6 months. For confirming polycystic ovaries, patients were interviewed thoroughly about their menstrual and fertility history. Blood investigations like LH, FSH were done on D2/D3 of menstrual cycle. 125 patients with PCOS were included in this study. The data was analysed with SPSS-IBM (V.22.0) software.Results: The patients having polycystic ovaries were higher in women of 21-30 years of age. BMI was more than 25. Infertility was found that 57%, hirsutism 45%, oligomenorrhoea 21% and amenorrhea 20%. On day 2, mean serum LH was 5.9±3.6 and serum FSH was 3.9±2.3. This study showed that the proportion of menstrual complaints is reported more in higher age group. Likewise lower income group presented with menstrual complaints. This was found to be statistically significant (P value <0.05).Conclusions: The study showed that patients diagnosed to have PCOS overweight. PCO in obese women had more severe ovulatory dysfunction. Infertility was the most common complaint.

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“…Undue raised LH appears to have adverse effects on the pregnancy outcome. [ 10 11 12 13 ] Escalated production of androgens associated with high LH concentrations, along with their ineffectual aromatization to estrogens related to the low FSH levels in PCOS patients, leads to local androgen surplus and estrogen shortfall within the ovary. [ 14 ] It accounts for a potent androgenic domain for the follicle which halts the follicular growth.…”

Section: Discussionmentioning

confidence: 99%

“…This results in chronic anovulation in patients with PCOS, which forms the basis for the cause of infertility. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Do basal luteinizing hormone and luteinizing hormone/follicle-stimulating hormone ratio have significance in prognosticating the outcome of In vitro fertilization cycles in polycystic ovary syndrome?

2021

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Context: Tonic hypersecretion of luteinizing hormone (LH) appears to impact both fertility and pregnancy outcomes in women with polycystic ovary syndrome (PCOS). Aim: Whether high basal day 2/3 serum LH levels and day 2/3 LH/follicle-stimulating hormone (FSH) ratio affect in vitro fertilization (IVF) cycle outcomes in PCOS patients undergoing controlled ovarian hyperstimulation using gonadotropin-releasing hormone (GnRH) antagonists. Settings and Design: A retrospective cohort study was conducted in Assisted Reproductive Technique Center, Department of Obstetrics and Gynaecology, at a tertiary care institute, on PCOS patients undergoing IVF/intracytoplasmic sperm injection (ICSI) using GnRH antagonist protocol with human chorionic gonadotropin trigger between January 2014 to December 2019. Methods and Material: Data related to patient's age, body mass index, day 2/3 serum FSH, serum LH, day 2/3 LH/FSH ratio, and infertility treatment-related variables were collected from the patient record files. IVF cycle characteristics, number of oocytes retrieved, number of embryos transferred were also recorded. The clinical pregnancy rate per embryo transfer was calculated. Statistical Analysis: Statistical software SPSS IBM version 24.0 was used to analyze the data. Descriptive statistics such as mean, standard deviation , and range values were calculated. To compare the difference between the groups, the paired t -test was applied for continuous variables and the Chi-square test for categorical variables. A value of P < 0.05 was considered statistically significant. Results: High basal day 2/3 LH level and day 2/3 LH/FSH ratio have no statistically significant effect on embryos formed, embryo transferred, and clinical pregnancy rate. However, fertilization rates were significantly less in these groups. Conclusion: The elevated basal day 2/3 LH and LH/FSH ratio do not impair the outcome of GnRH antagonist protocol treated IVF/ICSI cycles in PCOS women.

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The effect of baseline serum luteinizing hormone levels on follicular development, ovulation, conception and pregnancy outcome in infertile patients with polycystic ovarian syndrome

Cited by 8 publications

References 14 publications

Role of diagnostic hystero-laparoscopy in the evaluation of female infertility

Role of diagnostic hystero-laparoscopy in the evaluation of female infertility

Clinical and hormonal profile of patients diagnosed with polycystic ovarian syndrome at tertiary care hospital in Tamil Nadu

Do basal luteinizing hormone and luteinizing hormone/follicle-stimulating hormone ratio have significance in prognosticating the outcome of In vitro fertilization cycles in polycystic ovary syndrome?

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