The effect of Bacopa monnieri leaf extract on dietary supplementation in transgenic Drosophila model of Parkinson's disease

Siddique, Yasir Hasan; Mujtaba, Syed Faiz; Faisal, Mohammad; Jyoti, Smita; Naz, Falaq

doi:10.1016/j.eujim.2014.05.007

Cited by 35 publications

(20 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, aqueous extract of Mucuna pruriens had neuroprotective effect because it increased tyrosine hydroxylase (TH) immunoreactivity in the substantia nigra and striatum 32 . Given that acetone extract of Bacopa monnieri enhances climbing ability in transgenic Drosophila, expressing human alpha synuclein, thus can be a therapeutic strategy to control Parkinson's disease due to antioxidant and anti-apoptotic properties confirmed in this study 33 .…”

Section: Effects Of Extracts Isolated From Herbs In Treatment Of Parksupporting

confidence: 62%

“…Siddique et al, 2014 evaluated the effect of acetone extract of Centella asiatica on transgenic Drosophila expression of human α-synuclein. The results were showed the administration of Centella asiatica delays loss of climbing ability as well as reduces protein carbonyl and lipid peroxidation and increases content of glutathione, and glutathione-Stransferase activity in brain 29 . Examination of parameters of neuro-inflammation and behavioral after administration of Ligusticum officinale ethanol extract tomice with Parkinson model due to 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity was revealed the good effects of this herb to diminish inflammation and behavioral deficit.…”

Section: Effects Of Extracts Isolated From Herbs In Treatment Of Parkmentioning

confidence: 97%

See 1 more Smart Citation

Untitled

2018

IJPSR

View full text Add to dashboard Cite

Neurodegenerative disorders particularly Parkinson's disease are serious threat for heath society. In addition, treatment, control and managing of Parkinson's disease burden high cost to these patients. Therefore, an efficacy and available treatment strategy is required so that herbs and their bioactive compounds could be good candidates. It has well been demonstrated the herbs are a potential source of antioxidant and have anti-inflammatory property. Interestingly, oxidative stress and inflammation are main reasons neurodegeneration in substantia nigra pars compacta. Here, we review the studies conducted on effects of extracts and compounds obtained from herbs in treatment of Parkinson's disease until 2000 to now by to focus on their effects on different animal model of Parkinson's disease. INTRODUCTION: Among neurodegenerative disorders, Parkinson's disease is one of their most common, a disease due to obvious reduction of dopamine level in the striatum (Fig. 1), which have clinical characterization such as tremor, rigidity, myotonia, dyskinesia and psychosis autonomic dysfunction 1, 2. It have been proposed that genetic factors (mutation in the α-synuclein, LRRK2 and parkin genes) and environmental factors (neurotoxic pollutants) have pivotal role in progression of Parkinson's disease 3, 4 .

show abstract

Section: Effects Of Extracts Isolated From Herbs In Treatment Of Parksupporting

confidence: 62%

Section: Effects Of Extracts Isolated From Herbs In Treatment Of Parkmentioning

confidence: 97%

Untitled

2018

IJPSR

View full text Add to dashboard Cite

show abstract

“…Drosophila melanogaster that expresses wild-type human α-synuclein is a good model for investigating the synucleinopathic aspect of PD and for studying the promissing neuroprotective strategies [135]. Curcumin and EGCG added to the Drosophila's diet promoted the increased life span, recovered the loss of climbing ability, reduced protein carbonyl content as well as lipid peroxidation, and mitigated the death of brain cells [152][153][154][155]. Another strategy that should be considered in the prevention of protein fibrillation is the removal of oligomers and aggregates that is regulated by autophagic pathways that are impaired in PD [156].…”

Section: Protein Fibrillationmentioning

confidence: 99%

An Overview of Crucial Dietary Substances and Their Modes of Action for Prevention of Neurodegenerative Diseases

Pogačnik

Ota

Ulrih

2020

Cells

View full text Add to dashboard Cite

Neurodegenerative diseases, namely Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis are becoming one of the main health concerns due to the increasing aging of the world’s population. These diseases often share the same biological mechanisms, including neuroinflammation, oxidative stress, and/or protein fibrillation. Recently, there have been many studies published pointing out the possibilities to reduce and postpone the clinical manifestation of these deadly diseases through lifelong consumption of some crucial dietary substances, among which phytochemicals (e.g., polyphenols) and endogenous substances (e.g., acetyl-L-carnitine, coenzyme Q10, n-3 poysaturated fatty acids) showed the most promising results. Another important issue that has been pointed out recently is the availability of these substances to the central nervous system, where they have to be present in high enough concentrations in order to exhibit their neuroprotective properties. As so, such the aim of this review is to summarize the recent findings regarding neuroprotective substances, their mechanisms of action, as well as to point out therapeutic considerations, including their bioavailability and safety for humans.

show abstract

“…This approach has been used with success in Parkinson's Disease (Siddique et al. ). Induced pluripotent stem (iPS) cells could also be used to model XFS and study LOXL1 biology.…”

Section: Future Directions In Exfoliation Syndrome Researchmentioning

confidence: 99%

“…Other alternatives to learn about the cell biology of LOXL1 include the use of a rapidly aged, humanized drosophila model where the human LOXL1 gene variants can be inserted to study alterations in ocular phenotype. This approach has been used with success in Parkinson's Disease (Siddique et al 2014). Induced pluripotent stem (iPS) cells could also be used to model XFS and study LOXL1 biology.…”

Section: Future Directions In Exfoliation Syndrome Researchmentioning

confidence: 99%

Exfoliation syndrome: assembling the puzzle pieces

Pasquale

Borrás

Fingert

et al. 2015

Acta Ophthalmologica

View full text Add to dashboard Cite

ABSTRACT.Purpose: To summarize various topics and the cutting edge approaches to refine XFS pathogenesis that were discussed at the 21st annual Glaucoma Foundation Think Tank meeting in New York City, Sept. 19-20, 2014. Methods: The highlights of three categories of talks on cutting edge research in the field were summarized. Results: Exfoliation syndrome (XFS) is a systemic disorder with a substantial ocular burden, including high rates of cataract, cataract surgery complications, glaucoma and retinal vein occlusion. New information about XFS is akin to puzzle pieces that do not quite join together to reveal a clear picture regarding how exfoliation material (XFM) forms. Conclusion: Meeting participants concluded that it is unclear how the mild homocysteinemia seen in XFS might contribute to the disarrayed extracellular aggregates characteristic of this syndrome. Lysyl oxidase-like 1 (LOXL1) variants are unequivocally genetic risk factors for XFS but exactly how these variants contribute to the assembly of exfoliation material (XFM) remains unclear. Variants in a new genomic region, CACNA1A associated with XFS, may alter calcium concentrations at the cell surface and facilitate XFM formation but much more work is needed before we can place this new finding in proper context. It is hoped that various animal model and ex vivo systems will emerge that will allow for proper assembly of the puzzle pieces into a coherent picture of XFS pathogenesis. A clear understanding of XFS pathogenesis may lead to 'upstream solutions' to reduce the ocular morbidity produced by XFS.

show abstract

The effect of Bacopa monnieri leaf extract on dietary supplementation in transgenic Drosophila model of Parkinson's disease

Cited by 35 publications

References 32 publications

Untitled

Untitled

An Overview of Crucial Dietary Substances and Their Modes of Action for Prevention of Neurodegenerative Diseases

Exfoliation syndrome: assembling the puzzle pieces

Contact Info

Product

Resources

About